Cross-sectional analysis of myosteatosis and physical function in pretreatment head and neck cancer patients

Shaver, Amy L.; Noyes, Katia; Platek, Mary E.; Singh, Anurag; Erickson, Kayleigh; Wendel, Elizabeth; Wilding, Gregory E.; Ochs‐Balcom, Heather M.; Ray, Andrew D.

doi:10.1007/s00520-022-06808-x

Cited by 3 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lower IMAT/IMATI in our cohort may be related to their lower BMI and underlying cancer cachexia. However, decreased SMRA has been described as a feature of advanced cancers and associated with poorer muscle function and shorter overall survival in various cancer populations [16,19,41]. Shaver et al linked myosteatosis to decreased quality of life in HNC patients one year after treatment completion [42].…”

Section: Discussionmentioning

confidence: 99%

“…Currently, while a wide variety of diagnostic methods have been used to assess body composition, mainly muscle mass indices were evaluated, and only few studies have investigated the effects of muscle quality indices (SMRA and IMATI) [16][17][18][19]. The correlation between muscle mass and quality is not well understood in cancer patients and is an area of active research.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preoperative CT-Based Skeletal Muscle Mass Depletion and Outcomes after Total Laryngectomy

Salati

Mandralis

Becce

et al. 2023

Cancers

View full text Add to dashboard Cite

Purpose: To assess the role of preoperative CT-based skeletal muscle mass depletion on postoperative clinical outcomes and survival in patients who underwent total laryngectomy for cancer. Methods: Patients operated on between January 2011 and March 2020 were retrospectively included. Skeletal muscle area and intra- and inter-muscular fat accumulation were measured at the third lumbar vertebral level on preoperative CT scans. Skeletal muscle mass depletion was defined based on pre-established cut-off values. Their association with postoperative morbidity, length of stay (LOS), costs, and survival was assessed. Results: A total of 84 patients were included, of which 37 (44%) had preoperative skeletal muscle mass depletion. The rate of postoperative fistula (23% vs. 35%, p = 0.348), cutaneous cervical dehiscence (17% vs. 11%, p = 0.629), superficial incisional surgical site infections (SSI) (12% vs. 10%, p = 1.000), and unplanned reoperation (38% vs. 37%, p = 1.000) were comparable between the two patient groups. No difference in median LOS was observed (41 vs. 33 days, p = 0.295), nor in treatment costs (119,976 vs. 109,402 CHF, p = 0.585). The median overall survival was comparable between the two groups (3.43 vs. 4.95 years, p = 0.09). Conclusions: Skeletal muscle mass depletion alone had no significant impact on postoperative clinical outcomes or survival.

show abstract