Cross-Sectional and Longitudinal Associations of Comorbidities with Knee Symptoms and Radiographic Abnormalities of Osteoarthritis

Li, Xiaoxi; Pan, Feng; Zhu, Rui; Ge, Liru; Zhang, Xiaoyue; Wen, Xiangrui; Zhou, Jiantao; Cheng, Jiale; Pan, Faming; Cai, Guoqi

doi:10.1007/s40744-023-00625-2

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…The worldwide prevalence of osteoarthritis (OA) and diabetes mellitus (DM) has significantly increased, impacting approximately 16% and 11% of the overall population, respectively [1][2][3]. Some epidemiological investigations have suggested an association between DM, hyperglycemia, and OA [4][5][6][7]. Notably, the influence of DM extends beyond the mere existence of OA, adversely affecting pain levels and functional abilities in individuals with OA.…”

Section: Introductionmentioning

confidence: 99%

Association between High HbA1c Levels and Mast Cell Phenotype in the Infrapatellar Fat Pad of Patients with Knee Osteoarthritis

Tsukada,

Takata,

Aikawa

et al. 2024

IJMS

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Diabetes mellitus (DM) has been suggested as a potential risk factor for knee osteoarthritis (KOA), and its underlying mechanisms remain unclear. The infrapatellar fat pad (IPFP) contributes to OA through inflammatory mediator secretion. Mast cells’ (MCs) role in diabetic IPFP pathology is unclear. In 156 KOA patients, hemoglobin A1c (HbA1c) was stratified (HbA1c ≥ 6.5, n = 28; HbA1c < 6.5, n = 128). MC markers (TPSB2, CPA3) in IPFP were studied. Propensity-matched cohorts (n = 27 each) addressed demographic differences. MC-rich fraction (MC-RF) and MC-poor fraction (MC-PF) were isolated, comparing MC markers and genes elevated in diabetic skin-derived MC (PAXIP1, ARG1, HAS1, IL3RA). TPSB2 and CPA3 expression were significantly higher in HbA1c ≥ 6.5 vs. <6.5, both before and after matching. MC-RF showed higher TPSB2 and CPA3 expression than MC-PF in both groups. In the HbA1c ≥ 6.5 group, PAXIP1 and ARG1 expression were significantly higher in the MC-RF than MC-PF. However, no statistical difference in the evaluated genes was detected between the High and Normal groups in the MC-RF. Elevated TPSB2 and CPA3 levels in the IPFP of high HbA1c patients likely reflect higher numbers of MCs in the IPFP, though no difference was found in MC-specific markers on a cell-to-cell basis, as shown in the MC-RF comparison. These findings deepen our understanding of the intricate interplay between diabetes and KOA, guiding targeted therapeutic interventions.

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Section: Introductionmentioning

confidence: 99%

Association between High HbA1c Levels and Mast Cell Phenotype in the Infrapatellar Fat Pad of Patients with Knee Osteoarthritis

Tsukada,

Takata,

Aikawa

et al. 2024

IJMS

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Unveiling the Hidden Link: Stomach Disease as a Risk Factor for Knee Osteoarthritis

Yang,

et al. 2024

Preprint

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Background The knee joint is one of the most frequently affected joints in osteoarthritis (OA). However, the specific connection between gastric diseases and the occurrence of knee osteoarthritis (KOA) is currently unclear. The objective of this study is to explore the potential association between gastric diseases and KOA using the China Health and Retirement Longitudinal Study (CHARLS) database. Methods A total of 1053 subjects with complete information in 2018 from CHARLS database were included. First, the baseline characteristics of these subjects (covariates such as gender, residence, and smoke) were compared. Then, the relationship between stomach diseases and KOA was explored through 3 weighted multivariate logistic regression models. Afterwards, risk stratification analyses were taken to further confirm the stability of the correlation between stomach disease and KOA risk in different populations. The receiver operating characteristic (ROC) curve of model 3 was plotted to verify the predictive efficiency of stomach disease in KOA risk. Results we divided the subjects into 2 groups: the KOA group (n = 71) and the control group (n = 982). The baseline characteristics table revealed that substantial differences in heart attack, kidney illness, stomach disease, as well as health status between the KOA and control groups. Model 1 had an odds ratio (OR) of 3.05 (95% confidence interval (CI) = 1.75–5.30, P < 0.001). After adjusting for location, gender, and smoke, model 2's OR was 3.02 (95% CI = 1.73–5.28, P < 0.001), while model 3's OR was 2.48 (95% CI = 1.37–4.47, P = 0.002). The 3 models demonstrated that stomach disease and KOA were significantly associated and stomach disease was a risk factor for KOA, and the other covariates did not change the relationship. Risk stratification analyses indicated a stable association between stomach disease and KOA risk across populations. The area under the curve (AUC) was 0.722, indicating that model 3 had a good predictive accuracy. Conclusion In this study, we furtherly explored the correlation between stomach disease and KOA, and certified that stomach disease was a risk factor for KOA, which provided a reference for the correlation analysis between them.

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Cross-Sectional and Longitudinal Associations of Comorbidities with Knee Symptoms and Radiographic Abnormalities of Osteoarthritis

Cited by 2 publications

References 36 publications

Association between High HbA1c Levels and Mast Cell Phenotype in the Infrapatellar Fat Pad of Patients with Knee Osteoarthritis

Association between High HbA1c Levels and Mast Cell Phenotype in the Infrapatellar Fat Pad of Patients with Knee Osteoarthritis

Unveiling the Hidden Link: Stomach Disease as a Risk Factor for Knee Osteoarthritis

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