Cross‐sectional association between testosterone, sex hormone‐binding globulin and metabolic syndrome: The Healthy Twin Study

Moon, Heesun; Choi, Inyoung; Kim, Somi; Ko, Hyeonyoung; Shin, Jin Young; Lee, Kayoung; Sung, Joohon; Song, Yun-Mi

doi:10.1111/cen.13390

Cited by 24 publications

(24 citation statements)

References 38 publications

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“…The production of testosterone by Leydig cells is stimulated by LH, which is synthesized in the anterior pituitary gland [29]. Similar to previous studies, in the young, healthy, male subjects included in our analysis, testosterone and SHBG were significantly inversely correlated with fasting glucose, HbA1c, WHR, BMI, lipid parameters (total cholesterol, LDL-C, apolipoprotein B, triglycerides), as well as inflammatory biomarkers [25,28–31]. In observational studies it has been shown that men with lower testosterone levels are at higher risk for cardiovascular disease, and that subject on treatment with testosterone replacement therapy have a decreased risk of adverse cardiovascular events [28,32,33].…”

Section: Discussionsupporting

confidence: 82%

High progesterone levels are associated with family history of premature coronary artery disease in young healthy adult men

et al. 2019

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Background & aims The offspring of patients with premature coronary artery disease (P-CAD) are at higher risk for cardiovascular disease, compared with subjects without a family history (FH) of P-CAD. The increased risk for cardiovascular disease in subjects with FH of early-onset CAD results from unfavorable genetic variants as well as social, behavioral and environmental factors, which are more prevalent in this group. Previous studies have shown that specific sex hormone levels may be associated with the risk of cardiovascular disease. The aim of this study was to compare wide range of biochemical marker levels including i.e. the levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone, estradiol, testosterone and sex-hormone binding globulin (SHBG) between young healthy male adults with and without FH of P-CAD. Methods The study group consisted of young healthy Polish male adults enrolled in a MAGNETIC case-control study, who were recruited between July 2015 and October 2017. The inclusion criteria were as follows: male sex, age ≥18 and ≤35 years old, FH of P-CAD (cases) or no P-CAD in first-degree relatives (controls). The comparison of continuous and categorical variables was performed using the Student’s t-test or the U-Mann–Whitney test, and Fisher’s exact test, respectively. The correlations between FSH, LH, testosterone, progesterone, SHBG and other laboratory parameters were assessed using the Spearman rank correlation test. Both univariable and multivariable logistic regression analyses were performed to assess the association between analyzed variables and FH of P-CAD. Results A total of 411 subjects (223 cases and 188 controls) were included in the study. There was a higher prevalence of major cardiovascular risk factors in subjects with FH of P-CAD (smoking, higher total and LDL cholesterol levels, higher body mass index and lower HDL cholesterol level). Moreover, the offspring of patients with P-CAD had lower SHBG level, and higher LH and progesterone levels in the crude comparison, compared with individuals without FH of P-CAD. After adjustment for confounding variables, progesterone and LH were determined to be independently associated with FH of P-CAD. Conclusion Progesterone and LH levels are significantly associated with FH of P-CAD, independent of traditional risk factors for CAD.

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Section: Discussionsupporting

confidence: 82%

High progesterone levels are associated with family history of premature coronary artery disease in young healthy adult men

et al. 2019

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“…It is reported that lower TT and free testosterone (FT) levels are associated with hypertension. [6] However, some investigators have reported that TT and FT are not correlated with hypertension. [7,8] It has also been reported that lower SHBG is associated with hypertension.…”

Section: Introductionmentioning

confidence: 99%

Association of total testosterone, free testosterone, bioavailable testosterone, sex hormone–binding globulin, and hypertension

Yang

Li²,

Li³

et al. 2019

Medicine

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Low testosterone has been inversely associated with hypertension. Our objective was to determine the associations between total testosterone (TT), free testosterone (FT), bioavailable testosterone (BioT), sex hormone–binding globulin (SHBG), and hypertension. Two hundred fifty-three men were enrolled in this study. TT and SHBG were measured by chemiluminescent immunoassay, and FT and BioT were calculated. Hypertension was defined as systolic blood pressure (SBP) ≥140 mm Hg and/or diastolic blood pressure (DBP) ≥90 mm Hg. Our results showed that hypertensive men had higher SHBG levels, and lower FT and BioT, compared to normotensive men. FT and BioT were inversely associated with SBP and DBP after adjusting for covariates (age, smoking, alcohol consumption, and physical activity). Furthermore, there was a significant decrease in the odds ratios for hypertension in the third and fourth quartiles of BioT and FT, compared to the lowest quartile before and after adjusting for covariates. In contrast, the OR for hypertension in the third quartile of SHBG was lower than the highest quartile. Our data show that FT and BioT are inversely correlated with SBP, DBP, and hypertension in men.

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“…Free testosterone (FT) accounts for about 1–3% of total testosterone (TT). It’s generally regarded that decreased FT level was related to the presence of metabolic syndrome (MetS) [10, 11] and previous literatures proposed the regular test of FT in screening for hypogonadism [12]. Currently there’s been a few studies about FT in patients with PCa and the link between FT value and the aggressiveness of PCa has been demonstrated [13–16].…”

Section: Introductionmentioning

confidence: 99%

Free testosterone value before radical prostatectomy is related to oncologic outcomes and post-operative erectile function

2019

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PurposeTo investigate whether free testosterone (FT) prior to radical prostatectomy was related to post-operative oncologic outcomes, erectile function and continence.MethodsThe data of 586 patients with available information underwent treatment in our center was retrospectively reviewed. Total testosterone (TT) was tested by chemiluminescence immunoassay, and FT value was calculated using Vermeulen’s formula. Post-operative continence and erectile function were evaluated by the requirement of pad and the IIEF-5 score at 12 months.ResultsThe median TT and FT value was 344 ng/dL (interquartile, IQR 314–374) and 6.9 ng/dL (IQR 6.4–7.3), and 106 patients (18.1%) and 152 patients (25.9%) were evaluated as having low TT and low FT based on current guidelines. Low TT and FT value were both related to older age (both p < 0.001), concomitant diabetes (p = 0.018 & 0.049), higher possibility of pre-operative erectile dysfunction (ED, both p < 0.001), higher pre-operative PSA value (both p < 0.001), higher clinical stage (both p < 0.001) and higher Gleason score in biopsy (both p < 0.001). Low FT was related to higher risk for pT3 (p = 0.020) and high Gleason score (p = 0.011) in logistic regression. The median follow-up duration was 52 moths (IQR 29–67) and FT was found to be an independent risk factor for biochemical recurrence (p = 0.005). In logistic regression TT was related to pre-operative ED (p = 0.010) and FT was related to post-operative ED (p = 0.001).ConclusionLow FT value before radical prostatectomy was related to adverse pathological outcomes, biochemical recurrence and post-operative ED.

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Cross‐sectional association between testosterone, sex hormone‐binding globulin and metabolic syndrome: The Healthy Twin Study

Cited by 24 publications

References 38 publications

High progesterone levels are associated with family history of premature coronary artery disease in young healthy adult men

High progesterone levels are associated with family history of premature coronary artery disease in young healthy adult men

Association of total testosterone, free testosterone, bioavailable testosterone, sex hormone–binding globulin, and hypertension

Free testosterone value before radical prostatectomy is related to oncologic outcomes and post-operative erectile function

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