Cross‐sectional association of coffee and caffeine consumption with sex hormone‐binding globulin in healthy nondiabetic women

Bars, Florence Pihan-Le; Gusto, Gaëlle; Boutron‐Ruault, Marie‐Christine; Fagherazzi, Guy; Bonnet, Fabrice

doi:10.1111/cen.13411

Cited by 9 publications

(9 citation statements)

References 34 publications

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“…In a study among 1563 Norwegian men, coffee was positively associated with SHBG and total testosterone levels [ 48 ]. A recent French study in 2377 women reported that (caffeinated) coffee, but not tea intake, was positively related with SHBG levels, notably in postmenopausal women [ 49 ], confirming earlier studies on coffee and SHBG levels in women. Low SHBG levels are considered as a consistent marker of type 2 diabetes risk, especially in women [ 50 ].…”

Section: Discussionsupporting

confidence: 78%

Coffee or Tea? A prospective cohort study on the associations of coffee and tea intake with overall and cause-specific mortality in men versus women

Brandt

2018

Eur J Epidemiol

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Coffee and tea intake have been associated with reduced mortality, but no studies have investigated possible substitution effects. The relationship of mortality with coffee, tea, and substituting coffee with tea was investigated in the Netherlands Cohort Study. In 1986, 120,852 men and women aged 55-69 years provided information on dietary and lifestyle habits. Mortality follow-up until 1996 consisted of linkage to Statistics Netherlands. Multivariate case-cohort analyses were based on 8665 deaths and 3166 subcohort members with complete data on coffee, tea and confounders. Higher coffee intake was significantly, nonlinearly related to lower overall and cause-specific mortality in women. In men, coffee was significantly positively related to cancer and cardiovascular mortality, and inversely to respiratory and other causes of death. Tea intake was significantly, nonlinearly related to lower overall, cancer and cardiovascular mortality in men, but showed no association with mortality in women. In substitution analyses, increasing the proportion tea (replacing coffee with tea) was significantly and nonlinearly related to lower overall, cancer and cardiovascular mortality in men, but in women higher tea proportions were positively associated with overall mortality (and most causes of death). This study suggests that for men, compared to exclusive coffee drinkers, those drinking 30-50% tea showed the lowest mortality; any tea drinking seemed better than only coffee. For women, those who drank exclusively coffee or drinking up to 40% tea had the lowest mortality, but those drinking higher percentages of tea were at increased mortality risk [HR = 1.41 (95% CI 1.01-1.99) for 80-100% tea compared to exclusive coffee drinkers].

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Section: Discussionsupporting

confidence: 78%

Coffee or Tea? A prospective cohort study on the associations of coffee and tea intake with overall and cause-specific mortality in men versus women

Brandt

2018

Eur J Epidemiol

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“…However, no relation was observed with caffeinated coffee and sex hormones (93). Similar results were also reported in a cross-sectional study with 2377 women (100). Nonselective blocking of adenosine receptors by caffeine, chlorogenic acid, and other phytochemicals, resulted in enhanced intracellular concentration of cyclic AMP.…”

Section: Q4: Does Coffee Consumption Affect Menopause Time?supporting

confidence: 82%

Endocrine Effects of Coffee Consumption

Yazan¹,

Apaydın²,

Yavuz³

2020

Turk J Endocrinol Metab

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“…[ 1 ] Hepatic SHBG production is regulated by nutritional factors. [ 20–22 ] Since there are epidemiological evidences showing a positive relationship between coffee and caffeine consumption and SHBG plasma levels [ 26,27 ] we decided to test whether caffeine consumption could increase SHBG production and the related underlying molecular mechanisms. Our results using HepG2 cells showed that caffeine did not increase SHBG production in in vitro experiments.…”

Section: Discussionmentioning

confidence: 99%

“…Several clinical studies have reported a clear correlation between caffeine and SHBG levels. [ 26,27 ] We therefore decided to explore whether caffeine could affect SHBG production in vivo. To do so we used a humanized SHBG transgenic mice, which have been extensively used to determine the mechanisms regulating SHBG in vivo since regular mice do not express SHBG gene in their livers and do not have SHBG in their blood.…”

Section: Discussionmentioning

confidence: 99%

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Caffeine Upregulates Hepatic Sex Hormone‐Binding Globulin Production by Increasing Adiponectin Through AKT/FOXO1 Pathway in White Adipose Tissue

Brianso-Llort

Fuertes-Rioja

Ramos‐Perez

et al. 2020

Molecular Nutrition Food Res

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Scope Epidemiological studies have shown that caffeine increases serum sex hormone‐binding globulin (SHBG) levels. The relationship between caffeine and SHBG production has never been studied before at molecular level. The aim of this study is to examine whether caffeine regulates SHBG production and to determine the associated molecular mechanisms. Methods and results Two different studies are performed; in vitro studies using human HepG2 cells treated with caffeine (100 and 500 µm) and in vivo studies using a humanized SHBG transgenic mice drinking caffeine in the water (0.1 mg mL−1) for 12 days. The results show that caffeine does not change SHBG production in HepG2 cells. By contrast, caffeine treatment increases significantly hepatic SHBG production in human SHBG transgenic mice when compared with control mice. Caffeine increases adiponectin levels in epididymal adipose tissue of human SHBG transgenic mice. Moreover, caffeine increases adiponectin production by reducing protein kinase B (AKT) phosphorylation which increases forkhead box protein O1 (FOXO1) protein levels in 3T3‐L1 mature adipocytes and human SHBG transgenic mice. Finally, caffeine‐induced increase in adiponectin in turn upregulates hepatic hepatocyte nuclear receptor 4‐alpha (HNF‐4α) levels in human SHBG transgenic mice. Conclusions The results show that caffeine upregulates hepatic SHBG expression by increasing adiponectin production through AKT/FOXO1 pathway in the adipose tissue.

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Cross‐sectional association of coffee and caffeine consumption with sex hormone‐binding globulin in healthy nondiabetic women

Abstract: Consumption of high coffee and caffeine is associated with a reduced risk of low SHBG, an established risk marker for T2DM, which might contribute to the protective effects of coffee for type 2 diabetes.

Cited by 9 publications

References 34 publications

Coffee or Tea? A prospective cohort study on the associations of coffee and tea intake with overall and cause-specific mortality in men versus women

Coffee or Tea? A prospective cohort study on the associations of coffee and tea intake with overall and cause-specific mortality in men versus women

Endocrine Effects of Coffee Consumption

Caffeine Upregulates Hepatic Sex Hormone‐Binding Globulin Production by Increasing Adiponectin Through AKT/FOXO1 Pathway in White Adipose Tissue

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