Cross‐sectional biomarker comparisons in asthma monitoring using a longitudinal design: The eNose premise

Abdel‐Aziz, Mahmoud I.; Vries, Rob de; Lammers, Ariana; Xu, Binbin; Neerincx, Anne H.; Vijverberg, Susanne; Dagelet, Yennece W.F.; Kraneveld, Aletta D.; Frey, Urs; Lutter, René; Sterk, Peter J.; Zee, Anke H. Maitland‐van der; Sinha, Anirban

doi:10.1111/all.14354

Cited by 9 publications

(12 citation statements)

References 9 publications

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“…This tool has the potential to assess asthma control and tailoring asthma treatment. 147,148 In a study including participants between 6 and 18 years of age, Cavaleiro Rufo et al showed that the exhaled breath condensate volatilome analysis by an eNose has good accuracy for asthma identification being able to distinguish individuals with diagnosed pediatric asthma from those without the disease. 149 comes (VAS global, nose, eye, and asthma) but less well with a symptom-medication score.…”

Section: Proteins As Biomarkersmentioning

confidence: 99%

“…Digital asthma biomarkers: Exhaled breath analysis using an electronic nose (eNose) is a new technique. This tool has the potential to assess asthma control and tailoring asthma treatment 147,148 . In a study including participants between 6 and 18 years of age, Cavaleiro Rufo et al showed that the exhaled breath condensate volatilome analysis by an eNose has good accuracy for asthma identification being able to distinguish individuals with diagnosed pediatric asthma from those without the disease 149 .…”

Section: Asthma Diagnosis Precision Medicine and Biomarkersmentioning

confidence: 99%

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Advances and recent developments in asthma in 2020

Cevhertas

Öğülür

Maurer

et al. 2020

Allergy

126

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In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, diagnosis, and treatment of asthma. Many risk and protective factors and molecular mechanisms are involved in the development of asthma. Emerging concepts and challenges in implementing the exposome paradigm and its application in allergic diseases and asthma are reviewed, including genetic and epigenetic factors, microbial dysbiosis, and environmental exposure, particularly to indoor and outdoor substances. The most relevant experimental studies further advancing the understanding of molecular and immune mechanisms with potential new targets for the development of therapeutics are discussed. A reliable diagnosis of asthma, disease endotyping, and monitoring its severity are of great importance in the management of asthma. Correct evaluation and management of asthma comorbidity/ multimorbidity, including interaction with asthma phenotypes and its value for the precision medicine approach and validation of predictive biomarkers, are further detailed. Novel approaches and strategies in asthma treatment linked to mechanisms and endotypes of asthma, particularly biologicals, are critically appraised. Finally, due to the recent pandemics and its impact on patient management, we discuss the challenges, relationships, and molecular mechanisms between asthma, allergies, SARS-CoV-2, and COVID-19.

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Section: Proteins As Biomarkersmentioning

confidence: 99%

Section: Asthma Diagnosis Precision Medicine and Biomarkersmentioning

confidence: 99%

Advances and recent developments in asthma in 2020

Cevhertas

Öğülür

Maurer

et al. 2020

Allergy

126

View full text Add to dashboard Cite

show abstract

“…Furthermore, our group has previously shown that breath profiles change after an experimental rhinovirus‐16 (RV16) infection in healthy and asthmatic adults. 17 However, only single time‐point comparisons and group averages were examined. Now, studies investigating the potential of real‐time exhaled breath analysis to monitor and predict such episodes on a day‐to‐day basis should follow.…”

Section: Introductionmentioning

confidence: 99%

Increased day‐to‐day fluctuations in exhaled breath profiles after a rhinovirus challenge in asthma

Lammers

Brinkman

Nijenhuis

et al. 2021

Allergy

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“…This tool has the potential to assess asthma control and tailoring asthma treatment. 146,147 In a study including participants between 6 and 18 years of age, Cavaleiro Rufo et al showed that the exhaled breath condensate volatilome analysis by an eNose has good accuracy for asthma identification being able to distinguish individuals with diagnosed pediatric asthma from those without the disease. 148 Farraia et al demonstrated that the analysis of the exhaled volatile organic compounds profiles using an eNose could be used as a fast and non-invasive complementary assessment tool for the detection of uncontrolled asthma.…”

mentioning

confidence: 99%

Advances and Recent Developments in Asthma in 2020

Cevhertas

Öğülür

Maurer³

et al. 2020

Preprint

View full text Add to dashboard Cite

In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, diagnosis and treatment of asthma. Many risk and protective factors and molecular mechanisms are involved in the development of asthma. Emerging concepts and challenges in implementing the exposome paradigm and its application in allergic diseases and asthma are reviewed, including genetic and epigenetic factors, microbial dysbiosis and environmental exposure, particularly to indoor and outdoor substances. The most relevant experimental studies further advancing the understanding of molecular and immune mechanisms with potential new targets for the development of therapeutics are discussed. A reliable diagnosis of asthma, disease endotyping and monitoring its severity are of great importance in the management of asthma. Correct evaluation and management of asthma comorbidity/multimorbidity, including interaction with asthma phenotypes and its value for the precision medicine approach and validation of predictive biomarkers are further detailed. Novel approaches and strategies in asthma treatment linked to mechanisms and endotypes of asthma, particularly biologicals, are critically appraised. Finally, due to the recent pandemics and its impact on patient management, we discuss the challenges, relationships, and molecular mechanisms between asthma, allergies, SARS-CoV-2 and Covid-19.

show abstract

Cross‐sectional biomarker comparisons in asthma monitoring using a longitudinal design: The eNose premise

Cited by 9 publications

References 9 publications

Advances and recent developments in asthma in 2020

Advances and recent developments in asthma in 2020

Increased day‐to‐day fluctuations in exhaled breath profiles after a rhinovirus challenge in asthma

Advances and Recent Developments in Asthma in 2020

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