Cross-sectional long-term micronutrient deficiencies after sleeve gastrectomy versus Roux-en-Y gastric bypass: A pilot study

Alexandrou, Andreas; Armeni, Eleni; Kouskouni, Evangelia; Tsoka, Evangelia; Diamantis, Theodoros; Lambrinoudaki, Ιrene

doi:10.1016/j.soard.2013.07.014

Cited by 108 publications

(102 citation statements)

References 27 publications

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“…The distal jejunum is brought up and gastrojejunostomy or esophagojejunostomy is performed. Conversely, in RYGB and BPD, the lengths of the Roux (alimentary) limb and proximal segment (biliopancreatic limb) are adjusted according to preoperative clinical factors such as BMI, and the jejunum is usually transected 30-80 cm and 150-200 cm distal to the ligament of Treitz, respectively [8,[19][20][21] . As a result, our procedure can preserve a longer alimentary jejunum and thus contribute to copper absorption and the maintenance of SCLs.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Serum Copper State after Gastrectomy with Roux-en-Y Reconstruction for Gastric Cancer

Nakagawa

Kojima²,

Inokuchi³

et al. 2015

Dig Surg

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Background: Some recent reports have noted that copper deficiency can occur in obese patients who have undergone bariatric surgery, such as Roux-en-Y (RY) gastric bypass or biliopancreatic diversion, or in patients who receive enteral nutrition through a jejunostomy. No reports appear to have assessed the serum copper state of patients following gastrectomy with RY reconstruction for gastric cancer. Methods: A cross-sectional study was conducted from June 2013 to December 2014. Serum copper levels (SCLs) in 242 out-clinic patients who underwent curative gastrectomy were obtained. Patients were classified into an RY group (n = 208) and a non-RY group (n = 34). Results: Hypocupremia was identified in 3 patients in the RY group (1.4%), and 2 patients in the non-RY group (5.9%; p = 0.146), but none experienced any symptoms caused by hypocupremia. No significant difference in the mean SCL was seen between the RY group (105.8 ± 21.2 µg/dl) and non-RY group (107.9 ± 22.7 µg/dl; p = 0.499). In the RY group, the mean SCL was significantly lower in younger patients, patients with follow-up period <3 years, and male patients. Conclusion: Some patients developed hypocupremia after gastrectomy with RY reconstruction, but the number is acceptably low, and physical symptoms were unusual.

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Section: Discussionmentioning

confidence: 99%

Assessment of Serum Copper State after Gastrectomy with Roux-en-Y Reconstruction for Gastric Cancer

Nakagawa

Kojima²,

Inokuchi³

et al. 2015

Dig Surg

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“…Moreover, the proximal small intestine is the primary site of B vitamin absorption which creates a greater risk following RYGB for B vitamin deficiencies associated with reduced absorption of these nutrients. As a consequence, neurological complications associated with vitamin B 12 , thiamin, and folate deficiencies have been estimated to occur in up to 16 % bariatric surgery cases [2], resulting in compromised neurological function presenting within weeks to months following bariatric surgery. In general, vitamin B 12 deficiencies are more common with RYGB compared to SG (42.1 versus 5 %, respectively; P=0.003) [3] because of the restricted and malabsorptive aspect of the surgery.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of B Vitamin Supplementation Following Bariatric Surgery: Rapid Increases of Serum Vitamin B12

Moore

Sherman

2014

OBES SURG

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“…Alexandrou et al compared nutritional deficiencies in human patients in the four years following RYGBP and SG surgeries and found vitamin D, vitamin B12, and folate deficiency in patients who underwent both surgeries. 44 Despite the effect of malabsorption of nutrients and energy found in RYGBP, nutrients that are not digested by small intestine and pancreatic enzymes pass through the hindgut (cecum and large intestine) serving as subtract for microbial growth, and gas production leading to flatulence and other undesirable effects.…”

Section: Discussionmentioning

confidence: 99%

Effect of three different bariatric obesity surgery procedures on nutrient and energy digestibility using a swine experimental model

Gandarillas

Hodgkinson

Riveros

et al. 2015

Exp Biol Med (Maywood)

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Morbid obesity is a worldwide health concern that compromises life quality and health status of obese human subjects. Bariatric surgery for treating morbid obesity remains as one of the best alternatives to promote excess weight loss and to reduce comorbidities. We have not found studies reporting nutrients and energy balance considering digestibility trials in humans following surgery. The purpose of this study was to determine protein, lipid, fiber, energy, calcium, and phosphorous digestibility in a swine model that underwent ileal transposition (IT), sleeve gastrectomy with ileal transposition (SGIT), Roux-en-Y gastric bypass (RYGBP), and with sham operated animals (SHAM). Thirty-two pigs were randomly assigned to four laparoscopic procedures:, and Sham-operated pigs (n ¼ 8). From day 0 postsurgery to 130, pigs were weighed monthly to determine live weight and weight gain was calculated for each month postsurgery until day 130. Food intake in a metabolic weight basis was calculated by measuring ad libitum food intake at day 130. Swine were fitted into metabolic crates to determine digestibility coefficients of dry matter, protein, fat, fiber, ash, energy, calcium, and phosphorous from day 130. A one-way ANOVA and Student-Newman-Keuls were used to detect differences in weight, food intake, and digestibility coefficients. Digestibility values for dry matter, fiber, phosphorus, and energy showed no differences among groups (P > 0.05). However, significant differences (P 0.05) were encountered among groups for fat, protein, ash, and calcium digestibilities. The RYGBP procedure, when applied to the pig model, significantly reduced calcium, fat, and ash digestibility, which did not occur with SGIT or IT procedure, when compared with Sham-operated animals.

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Cross-sectional long-term micronutrient deficiencies after sleeve gastrectomy versus Roux-en-Y gastric bypass: A pilot study

Cited by 108 publications

References 27 publications

Assessment of Serum Copper State after Gastrectomy with Roux-en-Y Reconstruction for Gastric Cancer

Assessment of Serum Copper State after Gastrectomy with Roux-en-Y Reconstruction for Gastric Cancer

Effectiveness of B Vitamin Supplementation Following Bariatric Surgery: Rapid Increases of Serum Vitamin B12

Effect of three different bariatric obesity surgery procedures on nutrient and energy digestibility using a swine experimental model

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