Life and civilization in arid regions depend on the availability of freshwater. Arid alpine river basins, where hydrological processes are highly sensitive to rapid warming, act as vital water towers for lowland oases. However, scientific understanding of precipitation variability and related cryosphere-hydrology processes is extremely limited because of the scarcity of in situ observations. The upper Danghe River Basin (UDB, ∼14,000 km2) is an arid and westerly- dominated basin on the northeastern Tibetan Plateau and is the water source for the Dunhuang Oasis in China. We have established a comprehensive cryosphere-hydrometeorology observation network in the basin since 2014. At present, the network consists of 21 automatic rain gauges, 22 soil freeze-thaw monitoring stations, 4 automatic weather stations (AWS), and a 50-m gradient meteorological tower with an eddy covariance system. In particular, the 18 sites, located in remote areas without public networks, are equipped with new-generation BeiDou-3 communication terminals that enable the observations to be easily, safely, and reliably read and quality-controlled in near real-time from offices in the city or at home. This integrated observation network over the UDB that facilitates the monitoring of cryosphere- hydrology processes, land-atmosphere interactions, and local weather processes. In addition, the observations are helpful for the objective evaluation, and continual improvement, of hydrological models, satellite-retrieval products, and reanalysis datasets. Finally, the network is expected to promote a better understanding of the status and role of water towers in arid zones and to provide basic data support for the sustainable development of the Dunhuang Oasis and the Belt and Road.