Cross-sectional study examining the epidemiology of chronic pain in Nepal

Higgins, Cassie; Sharma, Saurab; Bimali, Inosha; Hales, Tim G.; Cameron, Paul A.; Smith, Blair H.; Colvin, Lesley

doi:10.1097/pr9.0000000000001067

Cited by 2 publications

(3 citation statements)

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“…Depression is a pressing global health concern, affecting over 300 million people of all ages and backgrounds 1–3 . According to the World Health Organization, depression is one of the leading causes of disability worldwide, and its prevalence continues to rise 4,5 . Its impact on individuals, communities, and economies is significant, with reduced productivity and increased healthcare costs 1,6,7 .…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] According to the World Health Organization, depression is one of the leading causes of disability worldwide, and its prevalence continues to rise. 4,5 Its impact on individuals, communities, and economies is significant, with reduced productivity and increased healthcare costs. 1,6,7 There is a growing recognition of the importance of addressing depression as a public health priority, and efforts are being made at both national and international levels to identify risk factors and promote effective treatments.…”

Section: Introductionmentioning

confidence: 99%

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Exploring Depression and Nutritional Covariates Amongst US Adults using Shapely Additive Explanations

Huang,

Huang

2023

Health Science Reports

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BackgroundDepression affects personal and public well‐being and identification of natural therapeutics such as nutrition is necessary to help alleviate this public health concern.ObjectiveThe study aimed to identify feature importance in a machine learning model using solely nutrition covariates.MethodsA retrospective analysis was conducted using a modern, nationally representative cohort, the National Health and Nutrition Examination Surveys (NHANES 2017−2020). Depressive symptoms were evaluated using the validated 9‐item Patient Health Questionnaire (PHQ‐9), and all adult patients (total of 7929 individuals) who completed the PHQ‐9 and total nutritional intake questionnaire were included in the study. Univariable regression was used to identify significant nutritional covariates to be included in a machine learning model and feature importance was reported. The acquisition and analysis of the data were authorized by the National Center for Health Statistics Ethics Review Board.Results7929 patients met the inclusion criteria in this study. The machine learning model had 24 out of a total of 60 features that were found to be significant on univariate analysis (p < 0.01 used). In the XGBoost model the model had an Area Under the Receiver Operator Characteristic Curve (AUROC) = 0.603, Sensitivity = 0.943, Specificity = 0.163. The top four highest ranked features by gain, a measure of the percentage contribution of the covariate to the overall model prediction, were Potassium Intake (Gain = 6.8%), Vitamin E Intake (Gain = 5.7%), Number of Foods and Beverages Reported (Gain = 5.7%), and Vitamin K Intake (Gain 5.6%).ConclusionMachine learning models with feature importance can be utilized to identify nutritional covariates for further study in patients with clinical symptoms of depression.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring Depression and Nutritional Covariates Amongst US Adults using Shapely Additive Explanations

Huang,

Huang

2023

Health Science Reports

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“…Chronic pain is typically described as pain that lasts for three months or more (1). Chronic pain is considered a global public health concern by the World Health Organization due to its significant impact on both individuals and society (2). The more severe form of chronic pain is neuropathic pain (NP) (1).…”

Section: Introductionmentioning

confidence: 99%

Neuropathic Pain Management, Pharmacological Approaches, Neuromodulation and Quality of Life

Ali,

Alqubaishi,

Asiri

et al. 2023

JOHS

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Neuropathic pain, which affects 7%–10% of the general population, is caused by a lesion or disease of the somatosensory system, which includes peripheral fibers and central neurons. There are numerous known causes of neuropathic pain, and as the world's population ages, the prevalence of diabetes mellitus rises, and cancer patients are more likely to survive postchemotherapy. Its occurrence is projected to rise. The intricacy of neuropathic symptoms, adverse outcomes, and challenging treatment choices all appear to contribute to the burden of chronic neuropathic pain. Crucially, neuropathic pain patients have a lower quality of life due to a higher need for prescription drugs, more frequent visits to the physician, the morbidity from the pain itself, and the underlying disease. The most effective strategy to treat neuropathic pain would employ the right combination of pharmacological and nonpharmacologic therapy. As first-line treatments, gabapentinoids, tricyclic antidepressants, and serotonin-norepinephrine reuptake inhibitors are advised while tramadol and opioids are regarded as second-line therapy. Because there are currently insufficient high-quality trials, cannabinoids are advised as third-line treatments, and methadone and some anticonvulsants are suggested as fourth-line therapies. In cases of failure of pharmacological therapy or other special considerations, neuromodulation therapy is suggested, which involves deep brain stimulation, spinal cord stimulation, transcranial magnetic stimulation, and transcranial current stimulation and is broadly categorized under invasive and non-invasive neuromodulation procedures. In this study, we aim to comprehensively review the existing management strategies for neuropathic pain, specifically in the context of pharmacological, neuromodulation, and quality of life domains.

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Cross-sectional study examining the epidemiology of chronic pain in Nepal

Abstract: A cross-sectional examination of 520 Nepali adults found a high prevalence of chronic pain, associated with female gender, older age, and heavy manual occupations.

Cited by 2 publications

References 53 publications

Exploring Depression and Nutritional Covariates Amongst US Adults using Shapely Additive Explanations

Exploring Depression and Nutritional Covariates Amongst US Adults using Shapely Additive Explanations

Neuropathic Pain Management, Pharmacological Approaches, Neuromodulation and Quality of Life

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