Cross‐sectional study of gastric ulcers of the squamous mucosa in Thoroughbred racehorses

Vatistas, Nicholas J.; Snyder, Jack R.; Carlson, Gary P.; Johnson, Brian F. G.; Arthu, R. M.; Thurmond, Mark; Zhou, Huifang; Lloyd, Kirsty

doi:10.1111/j.2042-3306.1999.tb05166.x

Cited by 132 publications

(128 citation statements)

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“…Gastric ulceration affects between 53 to 90% of adult horses and has been associated with colic, weight loss, and decreased performance (38,61). Many (81%) outwardly healthy Thoroughbreds in race training also have ulcers (61).…”

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confidence: 99%

Equine Stomachs Harbor an Abundant and Diverse Mucosal Microbiota

Perkins

Bakker

Burton

et al. 2012

Appl Environ Microbiol

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ABSTRACTLittle is known about the gastric mucosal microbiota in healthy horses, and its role in gastric disease has not been critically examined. The present study used a combination of 16S rRNA bacterial tag-encoded pyrosequencing (bTEFAP) and fluorescencein situhybridization (FISH) to characterize the composition and spatial distribution of selected gastric mucosal microbiota of healthy horses. Biopsy specimens of the squamous, glandular, antral, and any ulcerated mucosa were obtained from 6 healthy horses by gastroscopy and from 3 horses immediately postmortem. Pyrosequencing was performed on biopsy specimens from 6 of the horses and yielded 53,920 reads in total, with 631 to 4,345 reads in each region per horse. The microbiome segregated into two distinct clusters comprised of horses that were stabled, fed hay, and sampled at postmortem (cluster 1) and horses that were pastured on grass, fed hay, and biopsied gastroscopically after a 12-h fast (cluster 2). The types of bacteria obtained from different anatomic regions clustered by horse rather than region. The dominant bacteria in cluster 1 wereFirmicutes(>83% reads/sample), mainlyStreptococcusspp.,Lactobacillusspp. and,Sarcinaspp. Cluster 2 was more diverse, with predominantlyProteobacteria,Bacteroidetes, andFirmicutes, consisting ofActinobacillusspp.Moraxellaspp.,Prevotellaspp., andPorphyromonasspp.Helicobactersp. sequences were not identified in any of 53,920 reads. FISH (n= 9) revealed bacteria throughout the stomach in close apposition to the mucosa, with significantly moreStreptococcusspp. present in the glandular region of the stomach. The equine stomach harbors an abundant and diverse mucosal microbiota that varies by individual.

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confidence: 99%

Equine Stomachs Harbor an Abundant and Diverse Mucosal Microbiota

Perkins

Bakker

Burton

et al. 2012

Appl Environ Microbiol

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“…7 Entwicklung der Befunde am Pylorus bei den Fohlen der V2-Kontrollgruppe (n=20) und der V2-Pulver (n=20) des zweiten Versuchsabschnitts (Omeprazol-Pulver) von Tag 0 bis Tag 15 nach dem Absetzen Development of gastroscopic findings of the pyloric region for the foals of both groups between day 0 and day 15 after weaning ray (1995) ist es für eine Spontanheilung von Magengeschwüren bei Sportpferden essentiell, die Tiere in eine stressfreie Umgebung zu verbringen. Auch Jensen (1996) (Murray 1995, Vatistas et al 1999b (Stolte 1991), lässt sich aber bisher auf das Pferd nicht übertragen, da zwar der Nachweis von DNA-Sequenzen von H. pylori im Magen von Vollblutpferden mit Magenläsionen gelang, nicht aber der Nachweis von teilungsfähigen Keimen (Contreras et al 2007). …”

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Incidence of gastric ulcers in weanling foals and the treatment with Omeprazole

Dahlkamp¹,

Feige²,

Venner³

2012

PHK

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EinleitungDas Absetzen der Fohlen von der Mutterstute, das in der Regel zwischen dem fünften und dem siebten Lebensmonat erfolgt, ist mit einem mannigfaltigen Wechsel des Lebensumfeldes verbunden. Die Änderung der Haltung, die Futterumstellung sowie eine neue Gruppenkonstellation mit daraus resultierender Neugliederung des Sozialgefüges sind sowohl mit physischem als auch mit psychischem Stress verbunden, der Wegbereiter für das Entstehen von Magengeschwüren bei 561 M. Dahlkamp et al. Pferdeheilkunde 28 Pferdeheilkunde 28 (2012) Incidence of gastric ulcers in weanling foals and the treatment with OmeprazoleThe aim of this study was To assess the prevalence of gastric ulcers and the development of bodyweight of weanling foals before and after weaning and to evaluate the effect of treatment with Omeprazole on gastric findings after weaning. Weanlings (n=79) (5 to 7.5 month) were examined in two subsequent studies with about 40 foals each. Each study had 2 randomly formed groups of 20 foals, a treatment group and a control group. In the first study (V1) the foals received Omeprazole-paste 2.2mg /kg bwt q 24 h by oral administration. Foals of the second study (V2) received 4mg/kg bwt q 24 h of Omeprazole-powder via feeding, to avoid the stress of daily catching and oral administration. The control groups remained untreated. On day T0 and day T14 after weanling the body condition score (BCS) and the bodyweight were determined and foals were gastroscopied. The nonglandular, glandular and the pyloric region were scored separately. There were no significant differences between groups regarding body weight and BCS. Of all 79 foals included in this studies 38 foals had gastric lesions in one or more gastric regions before weaning. Control foals of both studies showed significant worsening in the nonglandular portion 14 days after weaning (V1-control: T0-6 foals and T14-16 foals; V2-control: T0-7 foals and T14-15 foals). Both of treated groups showed significant worse findings in the glandular and/or pyloric region on day 14 (gl.reg.: 1 foal / pyl.: 0 foal before and gl.reg.: 9 / pyl.: 6 after weaning in the Omeprazole-paste-study and gl.reg.: 1 / pyl.: 1 before and gl.reg.: 3 / pyl.: 10 after weaning in the omeprazole-powderstudy). There was a significant improvement in the nonglandular portion besides a significant worsening in the glandular portion and the pylorus in the treated groups. Omeprazole at 4mg/kg bwt q 24 h via feeding is effective to prevent and treat lesions of the nonglandular portion. Nevertheless Omeprazole seems to be associated to inflammation of the mucosa in the pyloric region. Practical significance: For the time being generalised prophylactic use of Omeprazole in weanlings in the protocol used here cannot be recommended.

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“…On the other hand, necropsy revealed multifocal gastric ulcers. Sports horses, such as performance and racehorses, have a high prevalence and severity of gastric ulcers (Hammond et al 1986;Murray et al 1989Vatistas et al 1999b;Pellegrini, 2005;Jonsson & Egenvall 2006;Orsini et al, 2009). A study conducted by Pellegrini (2005) showed that almost all performance horses have some kind of ulcer and that at least 60% of them have colonic ulcers.…”

Section: Gastric Ulcersmentioning

confidence: 99%