“…A Brazilian study showed that PWUS had a probability of engaging in high-risk sexual behaviors 3.64 times greater than non-substance-users [ 66 , 70 ]. Inconsistent condom use has been associated with DU in Brazil [ 47 , 66 , 68 , 71 , 72 , 73 , 74 ], Costa Rica [ 75 ], Colombia [ 53 , 54 , 65 , 76 ], Mexico [ 40 , 77 ], Chile [ 69 ], El Salvador [ 78 , 79 ], and Guatemala [ 80 ]. In regions with high rates of sex work, these associations might explain the link between female sex, HIV and DU.…”