Cross-Sectional Study of Lipids and Liver Enzymes Related to a Serum Biomarker of Exposure (ammonium perfluorooctanoate or APFO) as Part of a General Health Survey in a Cohort of Occupationally Exposed Workers

Sakr, Carine J.; Kreckmann, Kim H.; Green, John W.; Gillies, Peter J.; Reynolds, Julia L.; Leonard, Robin C.

doi:10.1097/jom.0b013e318156eca3

Cited by 162 publications

(139 citation statements)

References 35 publications

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“…However, those data are not always consistent. One cross-sectional study carried out among occupational population with a much higher exposure level observed a modest but statistically significant, positive relationship between serum PFOA and TC, LDLC, for each increase in 1 ng/mL in serum PFOA, TC and LDLC increases by 0.10 Â 10 À 3 and 0.07 Â 10 À 3 mmol/L, respectively (Sakr et al, 2007a). In a longitudinal study, Sakr et al (2007b) found serum PFOA was positively associated with TC, with an increase of 0.03 Â 10 À 3 mmol/L of cholesterol for each 1 ng/mL increase in PFOA.…”

Section: Discussionmentioning

confidence: 99%

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Wang

Fu³

et al. 2014

Ecotoxicology and Environmental Safety

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a b s t r a c tPerfluoroalkyl acids (PFAAs) have been used in a variety of products for many years and have been detected worldwide in human serum. Previous studies have suggested the potential effects of PFAAs on serum lipids. To investigate the associations between serum concentrations of PFAAs and serum lipid levels, 133 participants were randomly selected from the people coming for health check-up in Yuanyang Red Cross Hospital of Henan, China. Linear regression analysis revealed that perfluoro-octanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA), with a median concentration of 1.43, 0.37, and 0.19 ng/mL, respectively, were positively associated with total cholesterol (TC). Those in the highest quartile of PFOA exposure had ln-TC levels 0.24 mmol/L higher than those in the lowest quartile. For PFNA and PFDA, effect estimates were 0.25 and 0.16 mmol/L, respectively. A positive association between high-density lipoprotein cholesterol (HDLC) and PFDA was found, and there was a 0.18 mmol/L increase of HDLC for the top PFDA quartile compared with the lowest quartile. PFOA and PFNA were positively associated with low-density lipoprotein cholesterol (LDLC). Ln-LDLC levels of people in both top PFOA and PFNA quartiles were 0.33 mmol/L higher than those in the lowest quartiles. Logistic regression analysis indicated that increased PFOA and PFOS quartiles were positively associated with an increased risk of abnormal TC and LDLC when controlling for no confounding factors.

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Section: Discussionmentioning

confidence: 99%

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Wang

Fu³

et al. 2014

Ecotoxicology and Environmental Safety

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“…Prostate cancer mortality [11] Liver tumors, pancreatic acinar cell tumors, Leydig cell tumors [79] Hepatotoxicities Slight increases in total cholesterol, lowdensity lipoprotein, very low-density lipoprotein, gamma glutamyl aminotransferase, and aspartate aminotransferase [77] Hepatomegaly accompanied by mitochondrial proliferation, no peroxisome proliferation [85] Peroxisome proliferation, increased hepatocyte hypertrophy, increased labeling index [83] Developmental toxicities…”

Section: Pfoa Carcinogenicitymentioning

confidence: 99%

Environmental and biological monitoring of persistent fluorinated compounds in Japan and their toxicities

Harada

2008

Environ Health Prev Med

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Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) comprise a class of per- and poly-fluorinated compounds that have been detected in the environment as well as in humans. The aim of this review is to summarize several monitoring studies in Japan and characterize the toxicokinetics of these compounds. We found that the levels of contamination by these compounds had unique patterns in Japan. The levels of PFOA in serum from inhabitants of the Kansai region were higher than those of other regions. The PFOA levels in air and water samples from the Kansai region were also relatively high. The estimated intakes from these routes partly explain the differences in the serum levels. The toxicokinetics of these compounds have been investigated. Serum samples from male participants had significantly higher geometric means for PFOS and PFOA compared to samples from female participants. This sex-related difference was partly simulated by menstrual blood loss. There are large interspecies differences in the excretion pathways of these compounds. The serum clearances of PFOA via urine were 300-1,000-fold lower in humans than in Wistar rats and Japanese macaques. On the other hand, the biliary excretion of these compounds was comparable in rats and humans, and the long half-lives in humans may be attributable to the low levels of urinary excretion and high biliary reabsorption rates. These findings suggest that qualitative differences in the excretion routes exist between humans and other species. For risk assessment of these compounds, further information regarding sources of exposure and their toxicokinetics is needed.

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“…An association between perfluorooctane sulphonate ⁄ perfluorooctanoic acid (PFOA) levels and serum cholesterol was found in a large US cross-sectional study [60]. In a crosssectional study of 1025 workers with potential exposure to PFOA, the circulating levels of this compound were related to LDL cholesterol concentration [61].…”

Section: Lipidsmentioning

confidence: 99%

Can persistent organic pollutants and plastic‐associated chemicals cause cardiovascular disease?

Lind¹,

Lind

2012

Journal of Internal Medicine

104

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Abstract. Lind L, Lind PM (Uppsala University, Uppsala, Sweden). Can persistent organic pollutants and plastic-associated chemicals cause cardiovascular disease? (Review). J Intern Med 2012; 271: 537-553.During the last decade, associations between persistent organic pollutants (POPs), such as polychlorinated biphenyls, dioxins and pesticides, and cardiovascular (CV) risk factors and overt CV disease (CVD) have been reported in humans. Recently, associations between plastic-associated chemicals (PACs), such as bisphenol A and phthalates, and CVD have also begun to emerge. Several approaches to evaluating such associations have been used: accidents with a high level of exposure, occupational exposure studies, geographical studies of subjects living near a contaminated area and traditional case-control or cohort studies with measurements of circulating levels of different environmental contaminants in the general population. Exposure to POPs has consistently been associated with diabetes using all the approaches described above, including prospective studies. The evidence regarding associations between exposure to POPs and other CV risk factors, such as hypertension, obesity and lipids, is less strong and is mainly based on cross-sectional data. Associations between overt CVD and POPs have been reported using all the above approaches, but prospective data from population-based studies are still lacking to provide firm evidence of an important and independent role of POP exposure in the pathogenesis of CVD. Nevertheless, taken together, current evidence suggests that further longitudinal and experimental studies should be conducted to investigate the effect of exposure to both POPs and PACs, such as bisphenol A and phthalates.

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Cross-Sectional Study of Lipids and Liver Enzymes Related to a Serum Biomarker of Exposure (ammonium perfluorooctanoate or APFO) as Part of a General Health Survey in a Cohort of Occupationally Exposed Workers

Abstract: Our findings indicate a modest positive association of PFOA on some lipid parameters and a need for follow-up studies.

Cited by 162 publications

References 35 publications

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Environmental and biological monitoring of persistent fluorinated compounds in Japan and their toxicities

Can persistent organic pollutants and plastic‐associated chemicals cause cardiovascular disease?

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