Cross sectional study of microalbuminuria, C-peptide and fundal changes in pre-diabetics

Venkatesh, Prasanna K.; Jayasingh, K; Srikanth, Krishnamoorthy; Green, Siva R.

doi:10.18203/2349-3933.ijam20180943

Cited by 4 publications

(4 citation statements)

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“…This confirms that higher C-peptide in individuals with hypertension is independent of impaired glucose metabolism and cannot predict type 2 diabetes. Furthermore, among people with hypertension, C-peptide ability to predict type 2 diabetes in individuals with UAE ≥ 15 mg/24 h becomes worse compared with subjects UAE <15 mg/24 h. This would be justified by the association between insulin resistance and microalbuminuria in patients with essential hypertension and prediabetes [ 39 , 40 ]. The interaction between C-peptide and albuminuria was more remarkable than the interaction between C-peptide and eGFR.…”

Section: Discussionmentioning

confidence: 99%

Plasma C-Peptide and Risk of Developing Type 2 Diabetes in the General Population

Sokooti

Kieneker

Borst

et al. 2020

JCM

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C-peptide measurement may represent a better index of pancreatic β-cell function compared to insulin. While insulin is mainly cleared by liver, C-peptide is mainly metabolized by kidneys. The aim of our study was to evaluate the association between baseline plasma C-peptide level and the development of type 2 diabetes independent of glucose and insulin levels and to examine potential effect-modification by variables related to kidney function. We included 5176 subjects of the Prevention of Renal and Vascular End-Stage Disease study without type 2 diabetes at baseline. C-peptide was measured in plasma with an electrochemiluminescent immunoassay. Cox proportional hazards regression was used to evaluate the association between C-peptide level and type 2 diabetes development. Median C-peptide was 722 (566–935) pmol/L. During a median follow-up of 7.2 (6.0–7.7) years, 289 individuals developed type 2 diabetes. In multivariable-adjusted Cox regression models, we observed a significant positive association of C-peptide with the risk of type 2 diabetes independent of glucose and insulin levels (hazard ratio (HR): 2.35; 95% confidence interval (CI): 1.49–3.70). Moreover, we found significant effect modification by hypertension and albuminuria (p < 0.001 and p = 0.001 for interaction, respectively), with a stronger association in normotensive and normo-albuminuric subjects and absence of an association in subjects with hypertension or albuminuria. In this population-based cohort, elevated C-peptide levels are associated with an increased risk of type 2 diabetes independent of glucose, insulin levels, and clinical risk factors. Elevated C-peptide level was not independently associated with an increased risk of type 2 diabetes in individuals with hypertension or albuminuria.

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Section: Discussionmentioning

confidence: 99%

Plasma C-Peptide and Risk of Developing Type 2 Diabetes in the General Population

Sokooti

Kieneker

Borst

et al. 2020

JCM

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“…Reference range of C-peptide was considered as 0.8-3.1 ng/mL (0.26-1.03 nmol/L). 13,14 C-peptide was further categorized as <0.4 ng/mL (<0.13 nmol/L), 0.4-0.8 ng/mL (0.13-0.26 nmol/L) and >0.8 ng/mL (>0.26 nmol/L).…”

Section: This Prospective Study Was Conducted At Baqaimentioning

confidence: 99%

Relationship of C-peptide levels to duration of Type 1 diabetes – A study from Sindh, Pakistan

et al. 2020

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Objective: To determine the relationship of C-peptide levels with duration of type 1 diabetes mellitus. Methods: This prospective study was conducted at Baqai Institute of Diabetology and Endocrinology (BIDE), Baqai Medical University (BMU), Karachi-Pakistan from December 2013 to December 2015. A total of 184 subjects were recruited during the study period, 100 in Group-A and 84 in Group-B. Subjects clinically diagnosed with type 1 diabetes Mellitus (T1DM) were categorized into two groups based on duration of diabetes: Group-A (with ≤1-year duration of diabetes) and Group-B (with >1-year duration of diabetes). Ninety-nine of the 100 enrolled subjects in Group-A were diagnosed as having T1DM, with one subject who presented at 11.9 years of age and diagnosed with T2DM excluded from this study. Blood samples were drawn for biochemical parameters. Data for baseline characteristics and clinical parameters (HbA1c and C-peptide) were obtained from hospital management system of BIDE. Results: Fifty-seven (57.6%) subjects in Group-A, and 39 (46.4%) in Group-B were males. Mean±SD duration of diabetes (years) was 0.64±0.6 (range 0-1) in Group-A, and 7.65±5.5 (range 1-23) in Group-B. Family history of T1DM and T2DM was 1(1%) and 27(27.3%) in Group-A, and 8(9.52%) and 21(25%) in Group-B, respectively. Twenty-one (21.2%) subjects presented in diabetic ketoacidosis (DKA) in Group-A and 18(21.4%), in Group-B. Mean±SD for HbA1c was non-significantly higher in Group-A 11.12±2.31 compared to Group-B 10.42±1.45. Mean±SD for C-peptide was 1.91±1.53 ng/mL (0.60±0.481 nmol/L) in Group-A, and 1.82±1.01 (0.57±0.32 nmol/L) in Group-B (p=0.984). Conclusion: The study found that subjects with longer duration of T1DM had non-significantly decreased C-peptide levels compared to a group in which C-peptide was measured at or soon after diagnosis. Furthermore, C-peptide levels in many subjects with longer duration were higher than expected in classic T1DM. doi: https://doi.org/10.12669/pjms.36.4.1531 How to cite this:Fawwad A, Waris N, Askari S, Ogle G, Ahmedani MY, Basit A. Relationship of C-peptide levels to duration of Type 1 diabetes – A study from Sindh, Pakistan. Pak J Med Sci. 2020;36(4):---------. doi: https://doi.org/10.12669/pjms.36.4.1531 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Orthologous genes of C. annuum proteins involved in the pepper-PepGMV recovery response were also found in tomato and potato, which suggested the conservation of the defense response pathway in different hosts (Zanardo et al, 2019). Genes conferring resistance to tobacco mosaic virus (TMV, Tobamovirus), cucumber mosaic virus (CMV, Cucumovirus), tomato spotted wilt virus (TSWV, Tospovirus) and members of Potyvirus in tomato and potato have been found to co-map in the homologous genomic region in chilli (Kim et al, 2017;Venkatesh et al, 2018). However, using the Ty loci from tomato, Manisha et al (2017) was unable to identify genes in chilli that conferred resistance to begomovirus.…”

Section: Identification Of Resistance Gene Loci and Molecular Marker ...mentioning

confidence: 99%

Current status, breeding strategies and future prospects for managing chilli leaf curl virus disease and associated begomoviruses in Chilli (Capsicum spp.)

Nalla,

Schafleitner,

Pappu

et al. 2023

Front. Plant Sci.

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Chilli leaf curl virus disease caused by begomoviruses, has emerged as a major threat to global chilli production, causing severe yield losses and economic harm. Begomoviruses are a highly successful and emerging group of plant viruses that are primarily transmitted by whiteflies belonging to the Bemisia tabaci complex. The most effective method for mitigating chilli leaf curl virus disease losses is breeding for host resistance to Begomovirus. This review highlights the current situation of chilli leaf curl virus disease and associated begomoviruses in chilli production, stressing the significant issues that breeders and growers confront. In addition, the various breeding methods used to generate begomovirus resistant chilli cultivars, and also the complicated connections between the host plant, vector and the virus are discussed. This review highlights the importance of resistance breeding, emphasising the importance of multidisciplinary approaches that combine the best of traditional breeding with cutting-edge genomic technologies. subsequently, the article highlights the challenges that must be overcome in order to effectively deploy begomovirus resistant chilli varieties across diverse agroecological zones and farming systems, as well as understanding the pathogen thus providing the opportunities for improving the sustainability and profitability of chilli production.

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Cross sectional study of microalbuminuria, C-peptide and fundal changes in pre-diabetics

Cited by 4 publications

References 7 publications

Plasma C-Peptide and Risk of Developing Type 2 Diabetes in the General Population

Plasma C-Peptide and Risk of Developing Type 2 Diabetes in the General Population

Relationship of C-peptide levels to duration of Type 1 diabetes – A study from Sindh, Pakistan

Current status, breeding strategies and future prospects for managing chilli leaf curl virus disease and associated begomoviruses in Chilli (Capsicum spp.)

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