Cross-sectional study of serum parathyroid hormone level in high-risk pregnancies as compared to nonpregnant control

Abstract

Objectives:To note the value of serum parathyroid hormone (PTH) levels in normal and high-risk pregnancies (HRP) in patients attending antenatal visits at All India Institute of Medical Sciences (AIIMS).Materials and Methods:This is a cross-sectional study where a total of 282 patients attending Gynecology Outpatient Department at AIIMS, New Delhi were recruited. Among the 282 subjects, 251 were pregnant, and 31 were controls. The serum was tested for serum PTH levels using Beckman coulter access 2 immunoassay.Results:The median value of PTH level in pregnant women was 31.6 pg/ml with range being 0.8–505.5 pg/ml in contrast to 45.9 pg/ml with range being 19–102.7 pg/ml in nonpregnant female. This difference was statistically significant (P = 0.0012). There was no significant difference in median level of PTH in different age group. Although the median PTH levels were lower in second trimester (25.25 pg/ml) than in first trimester (35.5 pg/ml) and in third trimester (32.4 pg/ml), the difference was not statistically significant. There was no significant difference in PTH level in HRP (median value – 31.6 pg/ml) as compared to low-risk pregnancies (31.5 pg/ml).Conclusion:Serum PTH levels are significantly lower during pregnancy as compared to nonpregnant state. However, age, parity, and HRP did not alter PTH level during pregnancy.

Detection and Comparison of the Parathyroid Hormone Level with Periodontal Status of Pregnant Women

“…The findings of the present study were in contrast to the study done by Sharma et al 35 it was found that the serum PTH levels were significantly lower during pregnancy as compared to a nonpregnant state. It was found that there were no changes in serum PTH levels seen in high-risk pregnancies.…”

Reference intervals for clinical biochemistry and haematology tests during normal pregnancy

“…A lack of awareness of these changes in pregnancy may mask primary hyperparathyroidism or incorrectly diagnosis hypoparathyroidism. While previous studies have reported lower PTH levels [31][32][33] during pregnancy which is consistent with our findings, others have reported unchanged levels in comparison to the non-pregnant state. 34 Sepsis has been reported as the third most common cause of maternal mortality worldwide.…”

Parathyroid carcinoma presenting with ventricular bigeminy in pregnancy

“…It is well established that parathyroid carcinoma is associated with significantly elevated preoperative PTH levels 23–25. However, as a normal physiological response to pregnancy, PTH levels decrease to the low-normal range (10%–30% of the non-pregnant value) during the first and second trimester and normalise by term26–28 while ionised calcium levels remain relatively constant throughout pregnancy 26. These physiological changes could account for the levels observed in our case.…”