Excitation functions were measured for the formation of l81 Re, 182m Re, 1828 Re, 183 Re, 184m Re, ,84e Re and 186 Re in proton-induced reactions on natural tungsten in the energy range of 7.5-22.5 MeV. The excitation function for 186 W(p,n)' 86 Re reaction has been obtained with maximum cross section value of 41.6 ± 6.2 mb at the proton energy of 9.2 MeV. 186 Re was produced from the reaction induced by 16 MeV protons on isotopically enriched 186 W metal powder target. Following the separation from 187 W, 183 Ta and the bulk of target material ,86 W through an acid alumina column, 186 Re was concentrated and purified by an anion exchange column, and finally the no-carrier-added 186 Re saline solution was achieved. The radionuclidic purity of ,86 Re was > 99.2%. The experimental thick-target yield of l86 Re was determined to be approximately 50 μΟ/μΑΪι, in good agreement with that estimated from the excitation function.