Abstract. The detection of the 1809 keV emission line associated with the decay of 26 Al in the interstellar medium provides a direct evidence of recent nucleosynthesis events in our galaxy. 26 Al is thought to be mainly produced in massive stars, but in order to have a quantitative understanding of the 26 Al distribution, the cross section of all the nuclear reactions involved in its production should be accurately known. A recent sensitivity study demonstrated that the 25 Mg(α,n) 28 Si is the reaction with the strongest impact on the synthesis of 26 Al during explosive Neon and Carbon burning [4]. In order to improve the experimental knowledge of the 25 Mg(α,n) 28 Si cross section, a new direct measurement has been performed at Legnaro National Laboratories. The experimental setup, the data analysis and preliminary results are discussed.