Cross-Sensitivity and Aminoglycoside Antibiotics

“…In patients sensitized to neomycin, the percentage of cross-reactions to other aminoglycoside antibiotics is high: to paromomycin and butirosin 106 approximately 90%, to framycetin 70%, to ribostamycin 70%, 107 to tobramycin and kanamycin 60%, to gentamicin 50%, to amikacin 30%, 108 and to sisomicin 109 20% 2 . However, streptomycin cross-reacts (or coreacts more likely) in only approximately 4% of the patients 2,107,109 .…”

Section: Cross-reactions and Coreactionsmentioning

confidence: 99%

Allergic Contact Dermatitis From Topical Drugs: An Overview

Groot¹

2021

Dermatitis

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“…This may be reflected by a higher number of positive neomycin tests with ointments compared to creams (41). Schorr et al (11) have found stronger test responses with concentrations below 30% in petrolatum, and consider the 30% level in petrolatum to form a semisolid matrix with a paste-like consistency with a poorer release of allergens. In the current study, subject no.…”

Section: Vehiclementioning

confidence: 99%

“…1 disadvantage with the use of high concentrations of neomycin in intradermal tests is the risk of an anaphylactoid inflammatory response that may be provoked by solutions exceeding 0.1% (0.05 or 0.1 ml tests) (3,48). However, this view is not held by all investigators (11,49). Another disadvantage of intradermal tests is a transient traumatic reaction that results from injury of injecting needles.…”

Section: Alternativesmentioning

confidence: 99%

“…Sensitization appears to be associated with length of use (5,6), but has been reported down to a 5week-old infant (7). Apart from localized dermatitis, anaphylactic reactivity caused by contact with neomycin (8), response to ingestion (9), cross-reactivity with drugs (1,(10)(11)(12)(13)(14)(15)(16)(17) and a fixed drug eruption (18) have all been reported. Neomycin patch tests are among allergens in test series that most frequently generate positive tests (19).…”

mentioning

confidence: 99%

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Patch testing with neomycin sulfate

Bjarnason

Flosadóttir

2000

Contact Dermatitis

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The recommended patch test concentration of neomycin sulfate is 20% in petrolatum applied occluded for 48 h (2 days [D]). In the current study, the efficiency of such a test is compared to results with other techniques using lower allergen dose than obtained by approximately 20 microl of the 20% substance. Efficiency of petrolatum and demineralized water as vehicles are compared. 16 neomycin-sulfate positive subjects were retested with serial doses ranging from 0.4 to 0.0085 mg/cm2 neomycin sulfate in cellulose printed on polyester squares and applied by both tapes and plastic foils. Additionally, tests were performed with the 20% petrolatum substance in Finn Chambers. Tests containing the 20% substance in petrolatum and in water were applied directly with transparent foils. Readings ranged from 3 to 264 h (11D) following applications. Results show that foil applications of a polyester square dose, that is 7% of the dose obtained with the 20% substance, distinguished between perfusion of subjects who were visually positive and not with any test in the study. With the same test technique and visual assessments, 2 subjects were false-negative but developed doubtful test responses with the Finn Chambers.

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Cross-Sensitivity and Aminoglycoside Antibiotics

Cited by 36 publications

References 8 publications

Neomycin: a review with particular reference to dermatological usage

Neomycin: a review with particular reference to dermatological usage

Allergic Contact Dermatitis From Topical Drugs: An Overview

Patch testing with neomycin sulfate

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