Cross‐species comparison of behavioral neurodevelopmental milestones in the common marmoset monkey and human child

Ausderau, Karla; Dammann, Caitlin; McManus, Kathy; Schneider, Mary L.; Emborg, Marina E.; Schultz-Darken, Nancy

doi:10.1002/dev.21545

Cited by 17 publications

(22 citation statements)

References 56 publications

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“…It is important to consider vocal changes in context with the overall development of marmoset sensorimotor and social behavior [37]. Marmosets become more independent as fine motor skills and self-calming behaviors emerge between 4–8 weeks of age.…”

Section: Discussionmentioning

confidence: 99%

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Vocalization development in common marmosets for neurodegenerative translational modeling

Jones

Duffy

Hoffman

et al. 2018

Neurological Research

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Objectives In order to facilitate the study of vocalizations in emerging genetic common marmoset models of neurodegenerative disorders, we aimed to analyze call type changes across age in a translational research environment. We hypothesized that acoustic parameters of vocalizations would change with age, reflecting growth of the vocal apparatus and a maturation of control needed to make adult-like calls. Methods Nineteen developing common marmosets were longitudinally video- and audio-recorded between the ages of 1–149 days in a naturalistic setting without any vocalization elicitation protocol. Vocalizations were coded for call type (cry, tsik, trill, phee, and trill-phee) and analyzed for duration (sec), minimum & maximum frequency (Hz), and bandwidth (Hz). Mixed model linear regressions were performed to assess the effects of age on call parameters listed above for each call type. Results Cries decreased in duration (p=0.038), maximum frequency (p=0.047), and bandwidth (p=0.023) with age. Tsik calls decreased in duration (p=0.002) and increased in minimum frequency (p=0.004) and maximum frequency (p=0.005) with age. Trill calls increased in duration (p=0.003), and trillphee bandwidth (p=0.031) decreased with age. Discussion Our results demonstrate that development of common marmoset vocalizations is call type-dependent and that changes in acoustic parameters can be detected without complex vocalization elicitation paradigms or specialized audio recording equipment. Thus, we demonstrate the feasibility of a naturalistic protocol to collect and objectively analyze marmoset vocalizations longitudinally. This approach may be useful for studying vocal communication deficits in genetic models of neurodegenerative disorders.

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Section: Discussionmentioning

confidence: 99%

“…They begin to eat solid food unaided and engage in tree gouging and social play at around 12–16 weeks. Female sex hormones set in and social grooming behaviors emerge at 16–18 weeks [37]. Call rate decreases as marmosets reach adulthood [31].…”

Section: Discussionmentioning

confidence: 99%

Vocalization development in common marmosets for neurodegenerative translational modeling

Jones

Duffy

Hoffman

et al. 2018

Neurological Research

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“…For each data-set, I subsample the number of individuals and test for a linear plateau applied to the natural-logged values of the corpus callosum area against age expressed in days after conception. I also compare two datasets to capture when the corpus callosum growth ceases to grow in humans [35,36,40]. I test whether sample size impacts estimated age of corpus callosum growth cessation (b-d) and percentage of variance explained by the model (e-g).…”

Section: Discussionmentioning

confidence: 99%

Cutting across structural and transcriptomic scales translates time across the lifespan and resolves frontal cortex development in human evolution

Charvet

2020

Preprint

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How the unique capacities of human cognition arose in evolution is a question of enduring interest. It is still unclear which developmental programs are responsible for the emergence of the human brain. The inability to determine corresponding ages between humans and apes has hampered progress in detecting developmental programs leading to the emergence of the human brain. I harness temporal variation in anatomical, behavioral, and transcriptional variation to determine corresponding ages from fetal to postnatal development and aging, between humans and chimpanzees. This multi-dimensional approach results in 137 corresponding time points across the lifespan, from embryonic day 44 to ∼55 years of age, in humans and their equivalent ages in chimpanzees. I used these data to test whether developmental programs, such as the timeline of prefrontal cortex maturation, previously claimed to differ between humans and chimpanzees, do so once variation in developmental schedules is controlled for. I compared the maturation of frontal cortex projections from structural magnetic resonance (MR) scans and from temporal variation in the expression of genes used to track long-range projecting neurons (i.e., supragranular-enirhced genes) in chimpanzees and humans. Contrary to what has been suggested, the timetable of prefrontal cortex maturation is not unusually extended in humans. This dataset, which is the largest with which to determine corresponding ages across humans and chimpanzees, provides a rigorous approach to control for variation in developmental schedules and to identify developmental programs responsible for unique features of the human brain.

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“…The utility of common marmosets in research resulted in a recent increase in demand for these animals [ 6 ]. The Wisconsin National Primate Research Center (WNPRC) in Madison, Wisconsin, USA, houses a common marmoset colony typically consisting of about 240 common marmosets, which are used by researchers at the University of Wisconsin-Madison for groundbreaking research in neurological, neurobehavioral, and pharmacologic research, among many others [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Discovery of a Novel Simian Pegivirus in Common Marmosets (Callithrix jacchus) with Lymphocytic Enterocolitis

et al. 2020

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From 2010 to 2015, 73 common marmosets (Callithrix jacchus) housed at the Wisconsin National Primate Research Center (WNPRC) were diagnosed postmortem with lymphocytic enterocolitis. We used unbiased deep-sequencing to screen the blood of deceased enterocolitis-positive marmosets for viruses. In five out of eight common marmosets with lymphocytic enterocolitis, we discovered a novel pegivirus not present in ten matched, clinically normal controls. The novel virus, which we named Southwest bike trail virus (SOBV), is most closely related (68% nucleotide identity) to a strain of simian pegivirus A isolated from a three-striped night monkey (Aotus trivirgatus). We screened 146 living WNPRC common marmosets for SOBV, finding an overall prevalence of 34% (50/146). Over four years, 85 of these 146 animals died or were euthanized. Histological examination revealed 27 SOBV-positive marmosets from this cohort had lymphocytic enterocolitis, compared to 42 SOBV-negative marmosets, indicating no association between SOBV and disease in this cohort (p = 0.0798). We also detected SOBV in two of 33 (6%) clinically normal marmosets screened during transfer from the New England Primate Research Center, suggesting SOBV could be exerting confounding influences on comparisons of common marmoset studies from multiple colonies.

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Cross‐species comparison of behavioral neurodevelopmental milestones in the common marmoset monkey and human child

Cited by 17 publications

References 56 publications

Vocalization development in common marmosets for neurodegenerative translational modeling

Vocalization development in common marmosets for neurodegenerative translational modeling

Cutting across structural and transcriptomic scales translates time across the lifespan and resolves frontal cortex development in human evolution

Discovery of a Novel Simian Pegivirus in Common Marmosets (Callithrix jacchus) with Lymphocytic Enterocolitis

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