1991
DOI: 10.1111/j.1476-5381.1991.tb12388.x
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Cross tachyphylaxis to endothelin isopeptide‐induced hypotension: a phenomenon not seen with proendothelin

Abstract: 1 In anaesthetized rats, an i.v. injection of endothelin-1 (0.25nmolkg-') evoked a rapidly appearing (maximal effect within 15 s) and short lasting (3 min) fall in blood pressure with tachyphylaxis occurring so that it was reduced by 50% by the last of 4 injections given 10 min apart. This property was also shared by endothelin-2, endothelin-3 and vasoactive intestinal contractor (VIC). 2 Cross tachyphylaxis between the isopeptides occurred. However, under the same experimental conditions the hypotensive effec… Show more

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Cited by 24 publications
(4 citation statements)
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“…In DOCA‐salt hypertensive rats ( n = 3), the time course of decreases in MAP elicited by acetylcholine (5 μg/kg, i.v. ), used herein as a positive control [8,9,12], was determined and compared with that of EOAZ (20 mg/kg).…”
Section: Seriesmentioning
confidence: 99%
“…In DOCA‐salt hypertensive rats ( n = 3), the time course of decreases in MAP elicited by acetylcholine (5 μg/kg, i.v. ), used herein as a positive control [8,9,12], was determined and compared with that of EOAZ (20 mg/kg).…”
Section: Seriesmentioning
confidence: 99%
“…These experiments were performed in both intact rats (n = 6), and in rats (n = 5) which had been subjected to a bilateral vagotomy performed at the cervical level 15 min earlier. In another set of rats (n = 6), time-course of the decreases in MAP elicited by an i. v. injection of acetylcholine (5 mg/kg), used herein as positive control [11], [12], was determined and compared to that of EOAZ (20 mg/kg).…”
Section: Experimental Protocolmentioning
confidence: 99%
“…In another set of rats (n = 6), the time course of the decreases in MAP elicited by an injection of acetylcholine (5 mg/kg, i.v.) used as positive control (Degouville and Cavero 1991;Lahlou et al 2000) was determined and compared with that of 1,8-cineole (10 mg/kg).…”
Section: Seriesmentioning
confidence: 99%