Cross-Talk and Multiple Control of Target of Rapamycin (TOR) in Sclerotinia sclerotiorum

Jiao, Wenli; Ding, Weichen; Rollins, Jeffrey A.; Liu, Jinliang; Zhang, Yanhua; Zhang, Xianghui; Pan, Hongyu

doi:10.1128/spectrum.00013-23

Cited by 6 publications

(2 citation statements)

References 40 publications

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“…The signaling and regulatory factors of S. sclerotiorum involve the regulation of multiple genes. SsTOR is responsible for controlling cell wall integrity and virulence, and it participates in the rapamycin target signaling pathway ( Jiao et al, 2023 ). SsCat2 regulates catalase activity, affecting aspects such as cell membrane dryness and pathogenicity ( Huang et al, 2021 ).…”

Section: Reported Genes Regulating Virulence In Sclerotinia...mentioning

confidence: 99%

Recent advances in virulence of a broad host range plant pathogen Sclerotinia sclerotiorum: a mini-review

Zhu,

Wu,

Deng

et al. 2024

Front. Microbiol.

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Sclerotinia sclerotiorum is a typical necrotrophic plant pathogenic fungus, which has a wide host range and can cause a variety of diseases, leading to serious loss of agricultural production around the world. It is difficult to control and completely eliminate the characteristics, chemical control methods is not ideal. Therefore, it is very important to know the pathogenic mechanism of S. sclerotiorum for improving host living environment, relieving agricultural pressure and promoting economic development. In this paper, the life cycle of S. sclerotiorum is introduced to understand the whole process of S. sclerotiorum infection. Through the analysis of the pathogenic mechanism, this paper summarized the reported content, mainly focused on the oxalic acid, cell wall degrading enzyme and effector protein in the process of infection and its mechanism. Besides, recent studies reported virulence-related genes in S. sclerotiorum have been summarized in the paper. According to analysis, those genes were related to the growth and development of the hypha and appressorium, the signaling and regulatory factors of S. sclerotiorum and so on, to further influence the ability to infect the host critically. The application of host-induced gene silencing (HIGS)is considered as a potential effective tool to control various fungi in crops, which provides an important reference for the study of pathogenesis and green control of S. sclerotiorum.

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Section: Reported Genes Regulating Virulence In Sclerotinia...mentioning

confidence: 99%

Recent advances in virulence of a broad host range plant pathogen Sclerotinia sclerotiorum: a mini-review

Zhu,

Wu,

Deng

et al. 2024

Front. Microbiol.

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“…Appressoria play a crucial role in adhering to the host surface and penetrating the cuticle [14]. In the past few decades, some proteins related to the development and formation of appressoria have been identified and characterized in S. sclerotiorum, including mitogenactivated protein kinase (MAPK) signaling pathway proteins SsSte12 [15] and SsFkh1 [16], autophagy-related proteins SsATG8, SsNBR1 [17], SsFoxE3 [18], and SsAtg1 [19], as well as TOR signaling pathway protein SsTOR [20]. Additionally, secreted proteins SsRhs1 [21], Ssams2 [22], SsNsd1 [23], and Magnaporthe appressoria-specific (MAS) protein Sscnd1 [24] have also been confirmed to participate in appressoria formation.…”

Section: Introductionmentioning

confidence: 99%

The Sclerotinia sclerotiorum ADP-Ribosylation Factor 6 Plays an Essential Role in Abiotic Stress Response and Fungal Virulence to Host Plants

Wang,

Wang

et al. 2023

JoF

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The ADP-ribosylation factor 6 (Arf6), as the only member of the Arf family III protein, has been extensively studied for its diverse biological functions in animals. Previously, the Arf6 protein in Magnaporthe oryzae was found to be crucial for endocytosis and polarity establishment during asexual development. However, its role remains unclear in S. sclerotiorum. Here, we identified and characterized SsArf6 in S. sclerotiorum using a reverse genetic approach. Deletion of SsArf6 impaired hyphal growth and development and produced more branches. Interestingly, knockout of SsArf6 resulted in an augmented tolerance of S. sclerotiorum towards oxidative stress, and increased its sensitivity towards osmotic stress, indicative of the different roles of SsArf6 in various stress responses. Simultaneously, SsArf6 deletion led to an elevation in melanin accumulation. Moreover, the appressorium formation was severely impaired, and fungal virulence to host plants was significantly reduced. Overall, our findings demonstrate the essential role of SsArf6 in hyphal development, stress responses, appressorium formation, and fungal virulence to host plants.

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The Unknown within the Known: Nucleolus, Understudied Compartment in the Filamentous Fungi

Lee,

Dubey,

Jeon

2024

Mycobiology

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Nucleolus is the most conspicuous sub-nuclear compartment that is well known as the site of RNA polymerase I-mediated rDNA transcription and assembly of ribosome subunits in eukaryotes. Recent studies on mammalian cells suggest that functions of nucleolus are not limited to ribosome biogenesis, and that nucleolus is involved in a diverse array of nuclear and cellular processes such as DNA repair, stress responses, and protein sequestration. In fungi, knowledge of nucleolus and its functions was primarily gleaned from the budding yeast. However, little is known about nucleolus of the filamentous fungi. Considering that the filamentous fungi are multi-cellular eukaryotes and thus distinct from the yeast in many aspects, researches on nucleoli of filamentous fungi would have the potential to uncover the evolution of nucleolus and its roles in the diverse cellular processes. Here we provide a brief up-to-date overview of nucleolus in general, and evidence suggesting their roles in fungal physiology and development.

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Cross-Talk and Multiple Control of Target of Rapamycin (TOR) in Sclerotinia sclerotiorum

Abstract: TOR is a conserved protein kinase that regulates cell growth and metabolism in response to growth factors and nutrient abundance. Here, we used gene silencing to characterize SsTOR, which is a critical component of TOR signaling pathway.

Cited by 6 publications

References 40 publications

Recent advances in virulence of a broad host range plant pathogen Sclerotinia sclerotiorum: a mini-review

Recent advances in virulence of a broad host range plant pathogen Sclerotinia sclerotiorum: a mini-review

The Sclerotinia sclerotiorum ADP-Ribosylation Factor 6 Plays an Essential Role in Abiotic Stress Response and Fungal Virulence to Host Plants

The Unknown within the Known: Nucleolus, Understudied Compartment in the Filamentous Fungi

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