“Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review

Abstract

ObjectivesThe aim of this systematic review was to summarize the available literature on gut microbiome (GMB) and osteoarthritis (OA), analyze the correlation between GMB and OA, and explore potential underlying mechanisms.MethodsA systematic search of the PubMed, Embase, Cochrane, and Web of Science with the keywords “Gut Microbiome” and “Osteoarthritis” was conducted to identify the human and animal studies exploring the association between GMB and OA. The retrieval time range was from the database inception to July 31, 2022. Studies reported the other arthritic diseases without OA, reviews, and studies focused on the microbiome in other parts of the body with OA, such as oral or skin, were excluded. The included studies were mainly reviewed for GMB composition, OA severity, inflammatory factors, and intestinal permeability.ResultsThere were 31 studies published met the inclusion criteria and were analyzed, including 10 human studies and 21 animal studies. Human and animal studies have reached a consistent conclusion that GMB dysbiosis could aggravate OA. In addition, several studies have found that alterations of GMB composition can increase intestinal permeability and serum levels of inflammatory factors, while regulating GMB can alleviate the changes. Owing to the susceptibility of GMB to internal and external environments, genetics, and geography, the included studies were not consistent in GMB composition analysis.ConclusionThere is a lack of high-quality studies evaluating the effects of GMB on OA. Available evidence indicated that GMB dysbiosis aggravated OA through activating the immune response and subsequent induction of inflammation. Future studies should focus on more prospective, cohort studies combined with multi-omics to further clarify the correlation.

Peptidoglycan in osteoarthritis synovial tissue is associated with joint inflammation

“…Translocation of bacteria from the gastrointestinal tract through a permeable gut barrier has been postulated as a driver of surgical site infections [ 40 ]. Gut microbiota, intestinal permeability, GI inflammation, and other gut-associated factors are proposed to contribute to OA, so this phenomenon could also occur in the absence of clinical infection and could include bacterial byproducts [ 16 , 41 , 42 ]. Boer et al found that gut dysbiosis is associated with joint pain and inflammation [ 43 ].…”

Bioactives and their roles in bone metabolism of osteoarthritis: evidence and mechanisms on gut-bone axis

“…It has been reported that gut dysbiosis worsens osteoarthritis ( 91 ). A causal relationship has been established among microbial taxa such as Methanobacteriaceae, Ruminiclostridium, Desulfovibionale s and osteoarthritis ( 92 ).…”

Microbial Symphony: Exploring the Role of the Gut in Osteoarthritis-Related Pain. A Narrative Review

“…A strong relationship between OA and GM has been emerging in recent years since GM dysbiosis (an alteration in the amount, composition and diversity of microbiota [ 17 ]) can disrupt the gut barrier, activate the “gut–joint axis”, modulate innate and adaptive immunity through LPS release, short-chain fatty acid modification, macrophage activation, cytokine liberation, regulation of T-cell responses and B cells differentiation [ 18 , 19 ]. Moreover, GM can influence OA progression by interacting with other OA risk factors such as age, sex, obesity, inflammation, and mechanical load [ 20 ].…”