Cross-Talk between Lung and Systemic Circulation during Carbon Nanotube Respiratory Exposure. Potential Biomarkers

Erdely, Aaron; Hulderman, Tracy; Salmen, Rebecca; Liston, Angie; Zeidler-Erdely, Patti C.; Schwegler‐Berry, Diane; Castranova, Vincent; Koyama, Shozo; Kim, Yoong Ahm; Endo, Morinobu; Simeonova, Petia P.

doi:10.1021/nl801828z

Cited by 158 publications

(127 citation statements)

References 43 publications

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“…34,35 An increase of PAI-1 has been observed following exposure to either DEP 36 or carbon nanotubes. 37 In conjunction with the fibrinolytic factor PAI-1, in the present study we measured the coagulation factor fibrinogen and found a significant increase following exposure to 50 nm SiNPs. Our data suggest an impairment of the fibrinolytic system and activation of blood coagulation following SiNP exposure.…”

supporting

confidence: 51%

Amorphous silica nanoparticles impair vascular homeostasis and induce systemic inflammation

Nemmar¹,

Albarwani²,

Beegam³

et al. 2014

IJN

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Amorphous silica nanoparticles (SiNPs) are being used in biomedical, pharmaceutical, and many other industrial applications entailing human exposure. However, their potential vascular and systemic pathophysiologic effects are not fully understood. Here, we investigated the acute (24 hours) systemic toxicity of intraperitoneally administered 50 nm and 500 nm SiNPs in mice (0.5 mg/kg). Both sizes of SiNPs induced a platelet proaggregatory effect in pial venules and increased plasma concentration of plasminogen activator inhibitor-1. Elevated plasma levels of von Willebrand factor and fibrinogen and a decrease in the number of circulating platelets were only seen following the administration of 50 nm SiNPs. The direct addition of SiNPs to untreated mouse blood significantly induced in vitro platelet aggregation in a dose-dependent fashion, and these effects were more pronounced with 50 nm SiNPs. Both sizes of SiNPs increased lactate dehydrogenase activity and interleukin 1β concentration. However, tumor necrosis factor α concentration was only increased after the administration of 50 nm SiNPs. Nevertheless, plasma markers of oxidative stress, including 8-isoprostane, thiobarbituric acid reactive substances, catalase, and glutathione S-transferase, were not affected by SiNPs. The in vitro exposure of human umbilical vein endothelial cells to SiNPs showed a reduced cellular viability, and more potency was seen with 50 nm SiNPs. Both sizes of SiNPs caused a decrease in endothelium-dependent relaxation of isolated small mesenteric arteries. We conclude that amorphous SiNPs cause systemic inflammation and coagulation events, and alter vascular reactivity. Overall, the effects observed with 50 nm SiNPs were more pronounced than those with 500 nm SiNPs. These findings provide new insight into the deleterious effect of amorphous SiNPs on vascular homeostasis.

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supporting

confidence: 51%

Amorphous silica nanoparticles impair vascular homeostasis and induce systemic inflammation

Nemmar¹,

Albarwani²,

Beegam³

et al. 2014

IJN

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“…30,31 Aspiration of MWCNTs has also been reported to increase baroreflex activity in rats. 32,33 In addition, Erdely et al 34 reported transient elevation of blood inflammatory mediators after aspiration of MWCNTs, which may mediate this systemic microvascular response. Multiple exposures (aspiration of 20 μg/ mouse, every 2 weeks for 2 months) to SWCNTs also resulted in elevation of inflammation and oxidant stress markers in aortic tissue and augmentation of aortic plaques in atherosclerotic sensitive ApoE −/− mice.…”

Section: Cardiovascular Responsesmentioning

confidence: 99%

Occupational Nanosafety Considerations for Carbon Nanotubes and Carbon Nanofibers

2012

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CONSPECTUSCarbon nanotubes (CNTs) are carbon atoms arranged in a crystalline graphene lattice with a tubular morphology. CNTs exhibit high tensile strength, possess unique electrical properties, are durable, and can be functionalized. These properties allow applications as structural materials, in electronics, as heating elements, in batteries, in the production of stain-resistant fabric, for bone grafting and dental implants, and for targeted drug delivery. Carbon nanofibers (CNFs) are strong, flexible fibers that are currently used to produce composite materials.Agitation can lead to aerosolized CNTs and CNFs, and peak airborne particulate concentrations are associated with workplace activities such as weighing, transferring, mixing, blending, or sonication. Most airborne CNTs or CNFs found in workplaces are loose agglomerates of micrometer diameter. However, due to their low density, they linger in workplace air for a considerable time, and a large fraction of these structures are respirable.In rat and mouse models, pulmonary exposure to single-walled carbon nanotubes (SWCNTs), multi-walled carbon nanotubes (MWCNTs), or CNFs causes the following pulmonary reactions: acute pulmonary inflammation and injury, rapid and persistent formation of granulomatous lesions at deposition sites of large CNT agglomerates, and rapid and progressive alveolar interstitial fibrosis at deposition sites of more dispersed CNT or CNF structures.Pulmonary exposure to SWCNTs can induce oxidant stress in aortic tissue and increases plaque formation in an atherosclerotic mouse model. Pulmonary exposure to MWCNTs depresses the ability of coronary arterioles to respond to dilators. These cardiovascular effects may result from neurogenic signals from sensory irritant receptors in the lung. Pulmonary exposure to MWCNTs also upregulates mRNA for inflammatory mediators in selected brain regions, and pulmonary exposure to SWCNTs upregulates the baroreceptor reflex. In addition, pulmonary exposure to MWCNTs may induce levels of inflammatory mediators in the blood, which may affect the cardiovascular system.

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“…However, even relatively low concentrations of inhaled MWCNT appear to have significant effects on the systemic immune system (14,15). Erdely and coworkers also reported that SWCNT or MWCNT deposited into the lung induced acute lung and systemic effects, suggesting that the systemic response, if chronic and persistent, could trigger or exacerbate cardiovascular dysfunction and disease (16).…”

Section: Carbon Nanotubes and Interstitial Pulmonary Fibrosismentioning

confidence: 99%

Nanoparticles as a Potential Cause of Pleural and Interstitial Lung Disease

Bonner¹

2010

Proceedings of the American Thoracic Society

125

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Nanotechnology holds the promise of revolutionizing our society, bringing numerous beneficial innovations to improve structural materials, electronics, energy, medical imaging, and drug delivery, among other applications. However, nanomaterials present potential safety concerns, and there is accumulating evidence to suggest that nanoparticles may exert adverse effects on the lung and other organ systems. This article will overview the potential risks of engineered nanoparticles and nanotechnology on the respiratory system and highlight recent findings related to pulmonary and systemic effects of inhaled nanoparticles. Special emphasis will be given to carbon nanotubes and the possibility that these nanoparticles could represent an emerging risk for environmental and occupational lung disease, especially in individuals with pre-existing respiratory diseases such as asthma.Keywords: nanotechnology; nanomaterials; carbon nanotubes; fibrosis; pleura THE EMERGENCE OF NANOTECHNOLOGY AS A NEW HEALTH CONCERNHumans have been exposed to a multitude of naturally occurring nanosized particles (e.g., ultrafine particulates from volcanic activity or forest fires) throughout our evolution. Only over the past two decades have we had the capability to manipulate matter at the nanoscale level (1). The beneficial applications of nanotechnology in numerous industrial, consumer, and medical applications are extremely promising. These applications include those that may lead to more efficient water purification, stronger and lighter building materials, increased computing power and speed, improved generation and conservation of energy, and new tools for the diagnosis and treatment of disease. However, the outlook for a future improved by nanotechnology should be tempered by the fact that relatively little is known about the adverse effects of nanomaterials on human health and the environment (2). Rapid advances in nanotechnology have created a multitude of new structures, and we cannot precisely predict how these new nanomaterials will interact with biological systems.

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Cross-Talk between Lung and Systemic Circulation during Carbon Nanotube Respiratory Exposure. Potential Biomarkers

Cited by 158 publications

References 43 publications

Amorphous silica nanoparticles impair vascular homeostasis and induce systemic inflammation

Amorphous silica nanoparticles impair vascular homeostasis and induce systemic inflammation

Occupational Nanosafety Considerations for Carbon Nanotubes and Carbon Nanofibers

Nanoparticles as a Potential Cause of Pleural and Interstitial Lung Disease

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