2018
DOI: 10.1016/j.cell.2018.11.018
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Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications

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Cited by 18 publications
(31 citation statements)
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“…Indeed, KDM4A interacts with components of the replication machinery, facilitating rereplication at the TSSG sites (18). Consistent with these findings, we illustrated that targeting KDM4 family members through H3K4 methylation can result in TSSGs (10). This study reveals that lysine methyltransferases and demethylases have a high degree of specificity and work in concert to modulate site-specific DNA copy gains in the genome.…”
Section: Introductionsupporting
confidence: 84%
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“…Indeed, KDM4A interacts with components of the replication machinery, facilitating rereplication at the TSSG sites (18). Consistent with these findings, we illustrated that targeting KDM4 family members through H3K4 methylation can result in TSSGs (10). This study reveals that lysine methyltransferases and demethylases have a high degree of specificity and work in concert to modulate site-specific DNA copy gains in the genome.…”
Section: Introductionsupporting
confidence: 84%
“…EGFR DNA amplification is prevalent across a number of different cancer types, with up to 54% of patients exhibiting amplification in some tumor types (e.g., glioblastoma multiforme; ref. 10). An important clinical challenge with EGFR amplification is the plasticity of the amplification (12).…”
Section: Research Articlementioning
confidence: 99%
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