Cross talk mechanism of disturbed sleep patterns in neurological and psychological disorders

Sahu, Mehar; Tripathi, R.; Jha, Niraj Kumar; Jha, Saurabh Kumar; Ambasta, Rashmi K.; Kumar, Pravir

doi:10.1016/j.neubiorev.2022.104767

Cited by 7 publications

(5 citation statements)

References 215 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, a proper functioning of the circadian clock is critical to maintain homeostasis and physiological functions, and the perturbation of this system may result in severe pathologies including cancer 41,42 . Abnormal changes in circadian rhythms have been reported in jet lag 43 , night-shift workers 44 , cancer 45,46 , metabolic disorders 47,48 , mental disorders 49,50 , and also as a consequence of spaceflight [51][52][53] . Space travellers report circadian rhythm disruption during spaceflight, which is visible in many physiological aspects, for example shorter sleep durations 54 .…”

Section: Introductionmentioning

confidence: 99%

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

et al. 2023

View full text Add to dashboard Cite

The circadian clock regulates cellular and molecular processes in mammals across all tissues including skeletal muscle, one of the largest organs in the human body. Dysregulated circadian rhythms are characteristic of aging and crewed spaceflight, associated with, for example, musculoskeletal atrophy. Molecular insights into spaceflight-related alterations of circadian regulation in skeletal muscle are still missing. Here, we investigated potential functional consequences of clock disruptions on skeletal muscle using published omics datasets obtained from spaceflights and other clock-altering, external (fasting and exercise), or internal (aging) conditions on Earth. Our analysis identified alterations of the clock network and skeletal muscle-associated pathways, as a result of spaceflight duration in mice, which resembles aging-related gene expression changes observed in humans on Earth (e.g., ATF4 downregulation, associated with muscle atrophy). Furthermore, according to our results, external factors such as exercise or fasting lead to molecular changes in the core-clock network, which may compensate for the circadian disruption observed during spaceflights. Thus, maintaining circadian functioning is crucial to ameliorate unphysiological alterations and musculoskeletal atrophy reported among astronauts.

show abstract

Section: Introductionmentioning

confidence: 99%

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

et al. 2023

View full text Add to dashboard Cite

show abstract

“… 29 , 54 , 55 Although medication for fatigue management is routinely prescribed, there is a lack of evidence demonstrating a drug’s effectiveness in controlling MS-related fatigue. 56 , 57 There are non-pharmacological interventions with recent and notable evidence demonstrating effectiveness with fatigue management through exercise, CBT, massage, and neuromodulation therapies. 22 , 24 , 29–37 …”

Section: Resultsmentioning

confidence: 99%

“…29,54,55 Although medication for fatigue management is routinely prescribed, there is a lack of evidence demonstrating a drug's effectiveness in controlling MS-related fatigue. 56,57 There are non-pharmacological interventions with recent and notable evidence demonstrating effectiveness with fatigue management through exercise, CBT, massage, and neuromodulation therapies. 22,24,[29][30][31][32][33][34][35][36][37] Intervention studies in this review included three RCTs, one quasi-experimental trial, and a randomized prospective longitudinal pilot study.…”

mentioning

confidence: 99%

Interventions to Improve Quality of Life in Multiple Sclerosis: New Opportunities and Key Talking Points

Faraclas

2023

DNND

View full text Add to dashboard Cite

Background: Today, living well with multiple sclerosis (MS) is often measured by a person's overall quality of life rather than being limited to the more traditional metrics of reduced frequency of relapses or progression of disability. This change in focus, to a more holistic view of health, such as overall quality of life, has shifted the views of what both providers and people with multiple sclerosis view as essential for living well with MS. Purpose: This narrative review aims to examine the relevant literature on existing and emerging non-pharmacological interventions shown to improve the quality of life for people with multiple sclerosis across all health domains. Methods: A literature search was conducted on MEDLINE, CINAHL, and Scopus electronic databases using the following search terms: quality of life, health-related quality of life, life quality, life satisfaction, non-pharmacological intervention, non-drug, and intervention. After screening the abstracts, 24 were selected for this review. Results: Common non-pharmacological interventions were used for fatigue and sleep, mental and emotional health, cognition, physical health, and chronic pain. Several non-pharmacological interventions included in this review positively improved the overall quality of life for people with multiple sclerosis. These interventions included exercise, cognitive behavior therapy, and cognitive rehabilitation. Conclusion:Non-pharmacological interventions such as exercise and cognitive behavioral therapy improve the quality of life for people with MS. These interventions should be prescribed more during routine medical care. Translating this research into standard clinical practice should be one area of focus. In addition, higher quality studies, such as randomized control trials, need to be conducted on emerging nonpharmacological interventions to assess effectiveness.

show abstract

“…Aberrant brain iron increases with age, resulting in dysfunction of the central nervous system, since iron‐induced redox stress can accelerate cellular senescence and neurodegeneration. It has also been found that excessive iron accumulation is usually accompanied by sleep–wake phase disorders, which are closely related to the circadian rhythm 42,43 . Yet, the apparent relationship between elevated brain iron levels and circadian clock desynchrony in the elderly, and the mechanisms underlying these effects, represent a gap in our knowledge.…”

Section: Discussionmentioning

confidence: 99%

“…It has also been found that excessive iron accumulation is usually accompanied by sleep–wake phase disorders, which are closely related to the circadian rhythm. 42 , 43 Yet, the apparent relationship between elevated brain iron levels and circadian clock desynchrony in the elderly, and the mechanisms underlying these effects, represent a gap in our knowledge.…”

Section: Discussionmentioning

confidence: 99%

Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice

Wu,

Ren,

Wang

et al. 2024

CNS Neurosci Ther

View full text Add to dashboard Cite

AimsDisturbances in the circadian rhythm are positively correlated with the processes of aging and related neurodegenerative diseases, which are also associated with brain iron accumulation. However, the role of brain iron in regulating the biological rhythm is poorly understood. In this study, we investigated the impact of brain iron levels on the spontaneous locomotor activity of mice with altered brain iron levels and further explored the potential mechanisms governing these effects in vitro.ResultsOur results revealed that conditional knockout of ferroportin 1 (Fpn1) in cerebral microvascular endothelial cells led to brain iron deficiency, subsequently resulting in enhanced locomotor activity and increased expression of clock genes, including the circadian locomotor output cycles kaput protein (Clock) and brain and muscle ARNT‐like 1 (Bmal1). Concomitantly, the levels of period circadian regulator 1 (PER1), which functions as a transcriptional repressor in regulating biological rhythm, were decreased. Conversely, the elevated brain iron levels in APP/PS1 mice inhibited autonomous rhythmic activity. Additionally, our findings demonstrate a significant decrease in serum melatonin levels in Fpn1cdh5 ‐CKO mice compared with the Fpn1flox/flox group. In contrast, APP/PS1 mice with brain iron deposition exhibited higher serum melatonin levels than the WT group. Furthermore, in the human glioma cell line, U251, we observed reduced PER1 expression upon iron limitation by deferoxamine (DFO; iron chelator) or endogenous overexpression of FPN1. When U251 cells were made iron‐replete by supplementation with ferric ammonium citrate (FAC) or increased iron import through transferrin receptor 1 (TfR1) overexpression, PER1 protein levels were increased. Additionally, we obtained similar results to U251 cells in mouse cerebellar astrocytes (MA‐c), where we collected cells at different time points to investigate the rhythmic expression of core clock genes and the impact of DFO or FAC treatment on PER1 protein levels.ConclusionThese findings collectively suggest that altered iron levels influence the circadian rhythm by regulating PER1 expression and thereby modulating the molecular circadian clock. In conclusion, our study identifies the regulation of brain iron levels as a potential new target for treating age‐related disruptions in the circadian rhythm.

show abstract

Cross talk mechanism of disturbed sleep patterns in neurological and psychological disorders

Cited by 7 publications

References 215 publications

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

Interventions to Improve Quality of Life in Multiple Sclerosis: New Opportunities and Key Talking Points

Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice

Contact Info

Product

Resources

About