Cross‐vendor harmonization of T<sub>2</sub>‐relaxation‐under‐spin‐tagging (TRUST) MRI for the assessment of cerebral venous oxygenation

Jiang, Dengrong; Liu, Peiying; Li, Yang; Mao, Deng; Xu, Cuimei; Lu, Hanzhang

doi:10.1002/mrm.27080

Cited by 22 publications

(41 citation statements)

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“…The TRUST MRI technique used in our study allowed us to measure venous oxygenation, and therefore OEF, within 1.2 minutes of MRI examination time without injection of any exogenous agent or blood sampling. The technique used in this study has previously been tested for reproducibility and revealed an intrasession coefficient of variation of 2.0% ± 0.3, an intersession coefficient of variation of 2.6% ± 0.4 (29), and an interscanner coefficient of variation of 3.3% ± 0.6 (30).…”

Section: Discussionmentioning

confidence: 99%

Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden

Lin¹,

Sur²,

Soldan³

et al. 2019

Radiology

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Background: Apolipoprotein E4 (APOE4) is a major genetic risk factor for late-onset Alzheimer disease. However, the mechanisms by which APOE4 affects the brain, underpinning this risk, have not been fully elucidated. Purpose: To investigate the influence of APOE4 on global cerebral oxygen extraction fraction (OEF) and possible mediation through amyloid burden by using MRI-based brain oxygen extraction technique. Materials and Methods: Participants were enrolled from a longitudinal prospective study, the Biomarkers for Older Controls at Risk for Dementia study (data collected from January 2015 to December 2017), of whom 35% (50 of 143 participants) were APOE4 carriers. OEF was measured by using a T2-relaxation-under-spin-tagging MRI technique with a 3.0-T MRI system. PET acquired with carbon 11–labeled Pittsburgh compound B tracer was available in 119 participants to measure amyloid burden. Cognitive performance was assessed by using domain-specific composite scores including executive function, episodic memory, visual-spatial processing, and language. Linear regression analysis was performed to investigate the relationship between APOE4, OEF, and amyloid burden. The association between OEF and cognitive function was studied for the entire study cohort and separately for the APOE4 carriers and noncarriers. Results: A total of 143 cognitively healthy individuals (mean age ± standard deviation, 69.1 years ± 8.2; 57 men and 86 women) were studied. APOE4 genetic status was associated with lower OEF (noncarriers, 41.1% ± 5.8; one E4 allele, 40.1% ± 4.9; two E4 alleles, 36.7% ± 4.5; P = .03). Furthermore, among APOE4 carriers, lower OEF correlated with lower executive function scores (b = 0.079 z score for each percent change in OEF; P = .03). Amyloid burden and OEF were independently associated with APOE4 but were not associated with one another, suggesting that the effect of APOE4 on OEF is not mediated by amyloid. Conclusion: MRI-based brain oxygen extraction shows that cognitively healthy carriers of the apolipoprotein E4 gene manifest diminished brain oxygen extraction capacity independent of amyloid burden.

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Section: Discussionmentioning

confidence: 99%

Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden

Lin¹,

Sur²,

Soldan³

et al. 2019

Radiology

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“…A previous report on multi-vendor comparison of TRUST MRI has demonstrated that the performance of these two implementations is highly compatible. 44…”

Section: Methodsmentioning

confidence: 99%

Normal variations in brain oxygen extraction fraction are partly attributed to differences in end-tidal CO₂

Jiang

Lin

Liu

et al. 2019

J Cereb Blood Flow Metab

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Cerebral oxygen extraction fraction is an important physiological index of the brain’s oxygen consumption and supply and has been suggested to be a potential biomarker for a number of diseases such as stroke, Alzheimer’s disease, multiple sclerosis, sickle cell disease, and metabolic disorders. However, in order for oxygen extraction fraction to be a sensitive biomarker for personalized disease diagnosis, inter-subject variations in normal subjects must be minimized or accounted for, which will otherwise obscure its interpretation. Therefore, it is essential to investigate the physiological underpinnings of normal differences in oxygen extraction fraction. This work used two studies, one discovery study and one verification study, to examine the extent to which an individual’s end-tidal CO2 can explain variations in oxygen extraction fraction. It was found that, across normal subjects, oxygen extraction fraction is inversely correlated with end-tidal CO2. Approximately 50% of the inter-subject variations in oxygen extraction fraction can be attributed to end-tidal CO2 differences. In addition, oxygen extraction fraction was found to be positively associated with age and systolic blood pressure. By accounting for end-tidal CO2, age, and systolic blood pressure of the subjects, normal variations in oxygen extraction fraction can be reduced by 73%, which is expected to substantially enhance the utility of oxygen extraction fraction as a disease biomarker.

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“…13 Test-retest studies with subject repositioning showed that the OEF results are minimally dependent on the slice location. 12 Sequence parameters of FLAIR were: 3D acquisition, sagittal FOV = 240 × 240 × 165 mm 3 , voxel size = 1.1 × 1.1 × 1.1 mm 3 , TR = 4.8 sec, TI = 1.65 sec, TE = 276 msec, and total scan time = 4.2 minutes.…”

Section: Mri Experimentsmentioning

confidence: 99%

“…11 Advantages of the TRUST technique over 15 O PET are that it is radiation-free, rapid, noninvasive (without injecting any contrast agent), and scalable (can be used on any 3T MRI scanner without special hardware). 12,13 Our aim was to examine the relationship of OEF, as measured by MRI, to Alzheimer's pathology and vascular risk factors in a group of cognitively impaired patients with mixed Alzheimer's and vascular pathology.…”

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confidence: 99%

Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases

Jiang

Lin

Liu

et al. 2020

Magnetic Resonance Imaging

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Background: Alzheimer's disease and vascular cognitive impairment (VCI), as well as their concurrence, represent the most common types of cognitive dysfunction. Treatment strategies for these two conditions are quite different; however, there exists a considerable overlap in their clinical manifestations, and most biomarkers reveal similar abnormalities between these two conditions. Purpose: To evaluate the potential of cerebral oxygen extraction fraction (OEF) as a biomarker for differential diagnosis of Alzheimer's disease and VCI. We hypothesized that in Alzheimer's disease OEF will be reduced (decreased oxygen consumption due to decreased neural activity), while in vascular diseases OEF will be elevated (increased oxygen extraction due to abnormally decreased blood flow). Study Type: Prospective cross-sectional. Population: Sixty-five subjects aged 52-89 years, including 33 mild cognitive impairment (MCI), 7 dementia, and 25 cognitively normal subjects. Field Strength/Sequence: 3T T 2-relaxation-under-spin-tagging (TRUST) and fluid-attenuated inversion recovery imaging (FLAIR). Assessment: OEF, consensus diagnoses of cognitive impairment, vascular risk factors (such as hypertension, hypercholesterolemia, diabetes, smoking, and obesity), cognitive assessments, and cerebrospinal fluid concentration of amyloid and tau were assessed. Statistical Tests: Multiple linear regression analyses of OEF with diagnostic category (normal, MCI, or dementia), vascular risks, cognitive performance, amyloid and tau pathology. Results: When evaluating the entire group, OEF was found to be lower with more severe cognitive impairment (β = −2.70 AE 1.15, T = −2.34, P = 0.02), but was higher with greater vascular risk factors (β = 1.36 AE 0.55, T = 2.48, P = 0.02). Further investigation of the subgroup of participants with low vascular risks (N = 44) revealed that lower OEF was associated with worse cognitive performance (β = 0.04 AE 0.01, T = 3.27, P = 0.002) and greater amyloid burden (β = 92.12 AE 41.23, T = 2.23, P = 0.03). Among cognitively impaired individuals (N = 40), higher OEF was associated with greater vascular risk factors (β = 2.19 AE 0.71, T = 3.08, P = 0.004). Data Conclusion: These findings suggest that OEF is differentially affected by Alzheimer's disease and VCI pathology and may be useful in etiology-based diagnosis of cognitive impairment. Level of Evidence: 1 Technical Efficacy: Stage 3

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Cross‐vendor harmonization of T₂‐relaxation‐under‐spin‐tagging (TRUST) MRI for the assessment of cerebral venous oxygenation

Abstract: This work suggests that harmonized TRUST MRI can yield highly compatible Y measurements across different vendors. Magn Reson Med 80:1125-1131, 2018. © 2018 International Society for Magnetic Resonance in Medicine.

Cited by 22 publications

References 50 publications

Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden

Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden

Normal variations in brain oxygen extraction fraction are partly attributed to differences in end-tidal CO₂

Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases

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Cross‐vendor harmonization of T2‐relaxation‐under‐spin‐tagging (TRUST) MRI for the assessment of cerebral venous oxygenation

Abstract: This work suggests that harmonized TRUST MRI can yield highly compatible Y measurements across different vendors. Magn Reson Med 80:1125-1131, 2018. © 2018 International Society for Magnetic Resonance in Medicine.

Cited by 22 publications

References 50 publications

Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden

Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden

Normal variations in brain oxygen extraction fraction are partly attributed to differences in end-tidal CO2

Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases

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Cross‐vendor harmonization of T₂‐relaxation‐under‐spin‐tagging (TRUST) MRI for the assessment of cerebral venous oxygenation

Normal variations in brain oxygen extraction fraction are partly attributed to differences in end-tidal CO₂