Crossing-over within the HL–A System

Kissmeyer-Nielsen, F; Svejgaard, A.; Ahrons, S.; Nielsen, Lillian Staub

doi:10.1038/224075a0

Cited by 52 publications

(16 citation statements)

References 4 publications

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“…However, it is not yet certain whether these antigens belong to two genetically closely linked systems or form one complex locus. From analogy with the H-2 system in mice, the latter possibility seems more likely [6].A few cases of recombinations within the HL-A system have been reported [3][4][5], The cases of Batchelor and Chapman [2] and Ward et al [8] have been disputed [7], Another example of a clear-cut recombination is document ed here.The family P. A. was one of the normal families ascertained during the collection of controls in our HL-A studies. This family included both parents, a pair of non-identical twins (A.A. and M.A.)…”

mentioning

confidence: 97%

Another Recombination Within the HL-A System

Klouda¹,

Lawler²

1972

Vox Sanguinis

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mentioning

confidence: 97%

Another Recombination Within the HL-A System

Klouda¹,

Lawler²

1972

Vox Sanguinis

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“…The two sub-loci must, therefore, be closely linked. A probable crossing over between the two sub-loci has also recently been found, and is published elsewhere [8]. However, neither the low maximum recombination frequency nor the reported crossing over permit distinction between one or two HL-A cistrons, as recombinations may be intergenic or intragenic.…”

Section: Discussionmentioning

confidence: 95%

New HL-A Alleles

Thorsby¹,

Kissmeyer-Nielsen²

1970

Vox Sanguinis

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By immunization within specially selected donor-recipient pairs it was possible to produce antibodies against three new HL-A antigens. One of these was later found identical to Dal7, the other two are called Li of the LA series, and LND of the Four series of antigens. The antigens behaved in population and family studies as if they were determined by alleles at the LA and Four sub-loci. The present status of the HL-A system seems to be that 8 La alleles and 9 Four alleles are well defined. However, unknown HL-A antigens of low frequency still remain to be identified. The reported method seems to be very useful for this purpose.

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“…It may be of relevance that Colombani et al [2] observed two C'F sera reacting with about half of all Da4-positive cells; however, Da4 is not completely identical with the well-defined T12 (Toll) antigen. It may also be noted that unequivocal recombination within HL-A has been observed [7].…”

Section: Discussionmentioning

confidence: 99%

Complement-Fixing Platelet Iso-Antibodies V. HL-A Typing

Svejgaard¹,

Kissmeyer-Nielsen²

1970

Vox Sanguinis

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The reliability of the complement (C') fixation technique with platelets in HL-A typing was studied by parallel platelet and lymphocytotoxic typings of 1098 Scandinavians. With good typing sera the reproducibilities of the two techniques were equal and higher than 99.7%. The following HL-A antigens was demonstrated on platelets by means of C'-fixing (C'F) iso-antibodies: HL-A1, 2, 3, 5, 7, 8, 9, Ba*, ILN*, FJH, and BB. The corresponding antibodies were used in the platelet typing of between 20 and 525 unrelated Scandinavians and the results were compared with those obtained by means of lymphocytotoxic typing. Most of the specificities were detected identically or almost so in the two techniques. Preliminary studies of a new HL-A specificity, EL, are reported.

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Crossing-over within the HL–A System

Cited by 52 publications

References 4 publications

Another Recombination Within the HL-A System

Another Recombination Within the HL-A System

New HL-A Alleles

Complement-Fixing Platelet Iso-Antibodies V. HL-A Typing

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