2022
DOI: 10.3390/polym14122430
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Crosslinked Collagenic Scaffold Behavior Evaluation by Physico-Chemical, Mechanical and Biological Assessments in an In Vitro Microenvironment

Abstract: Wound healing-associated difficulties continue to drive biotechnological creativeness into complex grounds. The sophisticated architecture of skin wound sites and the intricate processes involved in the response to the use of regenerative devices play a critical role in successful skin regeneration approaches and their possible outcomes. Due to a plethora of complications involved in wound healing processes as well as the coordination of various cellular mechanisms, biomimetic approaches seems to be the most p… Show more

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Cited by 6 publications
(7 citation statements)
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“…The thermal and structural stability of the collagen triple helix is strongly influenced by the chemical composition of amino acid and its type, which is caused by the type of animal and the living conditions. Indeed, hydroxyproline stabilizes and strengthens the collagen structure [ 70 ]. In addition to preserving collagen’s structure and enhancing its mechanical properties, hydroxyproline also plays an important role in its thermal stability.…”
Section: Collagen: Structure and Propertiesmentioning
confidence: 99%
See 1 more Smart Citation
“…The thermal and structural stability of the collagen triple helix is strongly influenced by the chemical composition of amino acid and its type, which is caused by the type of animal and the living conditions. Indeed, hydroxyproline stabilizes and strengthens the collagen structure [ 70 ]. In addition to preserving collagen’s structure and enhancing its mechanical properties, hydroxyproline also plays an important role in its thermal stability.…”
Section: Collagen: Structure and Propertiesmentioning
confidence: 99%
“…Although fish collagen has several advantages, it suffers from several disadvantages such as low denaturation temperature, low mechanical properties, and high degradation rate [ 78 ]. The major drawback of fish collagen compared to mammalian collagen is the lower denaturation temperature, which limits its medical applications [ 70 ]. During denaturation, collagen turns into gelatin, where the hydrogen bonds that support the helical structure are partially or completely destroyed, and it loses its structural role and its conformation-related biological activity [ 42 , 43 ].…”
Section: Fish Collagenmentioning
confidence: 99%
“…Numerous factors could contribute to improved tissue regeneration. Regenerative properties of a xenograft are controlled by different graft physical properties, such as wettability [ 27 ], porosity [ 24 ], and crystallinity [ 52 ], among others [ 53 ]. For example, HA crystallinity regulates ossification and increases resorption rates during bone remodeling [ 52 ].…”
Section: Discussionmentioning
confidence: 99%
“…Regenerative properties of a xenograft are controlled by different graft physical properties, such as wettability [ 27 ], porosity [ 24 ], and crystallinity [ 52 ], among others [ 53 ]. For example, HA crystallinity regulates ossification and increases resorption rates during bone remodeling [ 52 ]. Go et al demonstrated that bone particles with a low crystallinity quickly degrade and produce faster bone regeneration than high-crystalline particles [ 54 ].…”
Section: Discussionmentioning
confidence: 99%
“…It is well known that biomacromolecules, such as collagen from many species, including bovine, porcine, and fish" provide an option for the fabrication of advanced bio-based materials [1]. Several previous authors found potential applications of collagen in industries as diverse as the pharmaceutical and biomedical industries, as collagen provides improves physical-chemical properties, mechanical stability, strength, biocompatibility, and biodegradability [2][3][4][5]. Collagen has potential applications in the cosmetics industry because of its properties as natural humectant and moisturizer for the skin [6].…”
Section: Introductionmentioning
confidence: 99%