Crosslinking dextran electrospun nanofibers via borate chemistry: Proof of concept for wound patches

Malini, Riccardo Innocenti; Lesage, Jessica; Toncelli, Claudio; Fortunato, Giuseppino; Rossi, René M.

doi:10.1016/j.eurpolymj.2018.11.017

Cited by 23 publications

(5 citation statements)

References 46 publications

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“…We report a method for the complete inclusion of aqueous droplets containing dyes, biomolecules or nanoparticles in PDMS under mild conditions that do not alter their biochemical properties or mobility, respectively. This new tool allows to create liquid phases into a polymeric matrix, a process that will be useful for the development of functional materials from photonic crystals, batteries, biosensors, storage devices, microreactors to transdermal drug delivery systems which are under investigation in forthcoming works 54 .…”

Section: Discussionmentioning

confidence: 99%

Complete inclusion of bioactive molecules and particles in polydimethylsiloxane: a straightforward process under mild conditions

Faccio

Cont

Mailand

et al. 2019

Sci Rep

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By applying a slow curing process, we show that biomolecules can be incorporated via a simple process as liquid stable phases inside a polydimethylsiloxane (PDMS) matrix. The process is carried out under mild conditions with regards to temperature, pH and relative humidity, and is thus suitable for application to biological entities. Fluorescence and enzymatic activity measurements show that the biochemical properties of the proteins and enzyme tested are preserved, without loss due to adsorption at the liquid-polymer interface. Protected from external stimuli by the PDMS matrix, these soft liquid composite materials are new tools of interest for robotics, microfluidics, diagnostics and chemical microreactors.

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Section: Discussionmentioning

confidence: 99%

Complete inclusion of bioactive molecules and particles in polydimethylsiloxane: a straightforward process under mild conditions

Faccio

Cont

Mailand

et al. 2019

Sci Rep

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“…3,37 A wide array of polymers has been used for active wound dressing applications, both synthetic and natural-origin. The polymers derived from natural resources include various polysaccharides such as cellulose, 43,44 starch, 45 dextran, 46,47 chitosan, [48][49][50] alginates, 51,52 hyaluronic acid, [53][54][55] but also some protein-based biopolymers including keratin 56 and collagen, 50,53,55 gelatin, 57,58 silk fibroin and sericin. 59 On the other hand, bioactive or bioinert synthetic polymers used in wound dressing research encompass some hydrophobic materials such as polycaprolactone, 60 polypropylene, 61 and poly(lactic acid), [62][63][64] and different hydrophilic synthetic polymers, for example, poly(vinyl alcohol), [65][66][67] poly(methacrylic acid) 68 and poly(ethylene glycol).…”

Section: Polymer Hydrogels and Films For Wound Dressing Applicationsmentioning

confidence: 99%

A comprehensive review of the polymer‐based hydrogels with electrochemically synthesized silver nanoparticles for wound dressing applications

Nešović

Mišković‐Stanković

2020

Polymer Engineering & Sci

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Modernization and improvement of wound dressing materials is an important topic in biomaterials and biomedicine fields, as the traditional materials are inadequate and susceptible to bacterial infections. In recent times, polymerbased hydrogel materials have presented themselves as excellent candidates for new-generation wound dressings with improved properties, such as high sorption ability, good mechanical properties, and low adhesiveness. Additionally, cross linked hydrogel matrices serve as excellent carriers for controlled release of antibacterial agents, such as silver nanoparticles (AgNPs), which are preferred over conventional antibiotics due to multi-phase mechanism of action and low susceptibility to induce bacterial resistance. Their incorporation inside polymer matrices allows improvement of wound dressing properties and sustained protection against bacterial infection. Electrochemical methods for AgNPs synthesis are facile and green alternatives to chemical routes, allowing the formation of highly stable AgNPs with strong antibacterial effect. In this article, we aim to provide a comprehensive review of the existing research on the topic of electrochemically synthesized silver nanoparticles incorporated in polymer matrices with a special focus on the chitosan-based hydrogels as prospective materials for wound dressing applications.

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“…Wound healing involves a series of complex biological processes [ 12 ]. At this point, good wound management measures are crucial for wound healing.…”

Section: Introductionmentioning

confidence: 99%

“…At this point, good wound management measures are crucial for wound healing. Currently, wound management measures include debridement, infection control, and wound dressings [ 12 , 13 , 14 , 15 ]. An ideal wound dressing should not only maintain the moist environment required for wound healing [ 16 , 17 , 18 ], but also have good breathability [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Polymer-Based Wound Dressings Loaded with Ginsenoside Rg3

et al. 2023

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The skin, the largest organ in the human body, mainly plays a protective role. Once damaged, it can lead to acute or chronic wounds. Wound healing involves a series of complex physiological processes that require ideal wound dressings to promote it. The current wound dressings have characteristics such as high porosity and moderate water vapor permeability, but they are limited in antibacterial properties and cannot protect wounds from microbial infections, which can delay wound healing. In addition, several dressings contain antibiotics, which may have bad impacts on patients. Natural active substances have good biocompatibility; for example, ginsenoside Rg3 has anti-inflammatory, antibacterial, antioxidant, and other biological activities, which can effectively promote wound healing. Some researchers have developed various polymer wound dressings loaded with ginsenoside Rg3 that have good biocompatibility and can effectively promote wound healing and reduce scar formation. This article will focus on the application and mechanism of ginsenoside Rg3-loaded dressings in wounds.

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Crosslinking dextran electrospun nanofibers via borate chemistry: Proof of concept for wound patches

Cited by 23 publications

References 46 publications

Complete inclusion of bioactive molecules and particles in polydimethylsiloxane: a straightforward process under mild conditions

Complete inclusion of bioactive molecules and particles in polydimethylsiloxane: a straightforward process under mild conditions

A comprehensive review of the polymer‐based hydrogels with electrochemically synthesized silver nanoparticles for wound dressing applications

Polymer-Based Wound Dressings Loaded with Ginsenoside Rg3

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