2023
DOI: 10.1039/d3sm00721a
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Crosslinking strategies in modulating methylcellulose hydrogel properties

Lorenzo Bonetti,
Luigi De Nardo,
Silvia Farè

Abstract: This review explores the possible crosslinking approaches for methylcellulose hydrogels, elucidating each crosslinking method's role in modulating the hydrogels’ properties.

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Cited by 13 publications
(4 citation statements)
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References 93 publications
(234 reference statements)
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“…As for the MC-directed PL, the observed stabilization is attributed to the high viscosity of the MC aqueous solution at relatively low concentrations, which leads to an increase in the viscous resistance, creating a quasi-equilibrium with the buoyancy of the SSAMs in the MC aqueous solution. Actually, the LCST of MC aqueous solution (2.0 wt%) is too high (55–60 °C), 22 which prevents us from investigating the properties of MC-directed PLs at ambient temperature, leading us to develop a modified MC-directed PL with relatively lower sol–gel transition temperature. Theoretically, the points where the energy storage modulus ( G ′) intersects with the loss modulus ( G ′′) in the rheological curve (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…As for the MC-directed PL, the observed stabilization is attributed to the high viscosity of the MC aqueous solution at relatively low concentrations, which leads to an increase in the viscous resistance, creating a quasi-equilibrium with the buoyancy of the SSAMs in the MC aqueous solution. Actually, the LCST of MC aqueous solution (2.0 wt%) is too high (55–60 °C), 22 which prevents us from investigating the properties of MC-directed PLs at ambient temperature, leading us to develop a modified MC-directed PL with relatively lower sol–gel transition temperature. Theoretically, the points where the energy storage modulus ( G ′) intersects with the loss modulus ( G ′′) in the rheological curve (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…At low temperatures, the HA/methylcellulose mixture remains freely flowable, allowing it to be conveniently injected or administered surgically. However, as its temperature rises towards 37 • C or body heat, it starts to physically cross-link and forms a gel scaffold [94,95]. This temperature-induced transition permits the co-polymer blend to be delivered minimally invasively in liquid form, after which it sets into a three-dimensional network within the body, which is well suited for tissue regeneration applications [96].…”
Section: Temperature-induced Gelationmentioning
confidence: 99%
“…34 Compared with traditional evaporation carriers, polyvinyl alcohol (PVA) hydrogel is a polymeric network with a three-dimensional porous structure, with a large surface area and numerous channels. 35–37 The hydrogel carrier possesses high water absorption capacity and good water retention. Moreover, the water in a PVA hydrogel has almost the same properties as bulk liquid water.…”
Section: Introductionmentioning
confidence: 99%