The world's population is aging as fertility rates have fallen to very low levels in most regions and life expectancy has been increasing [1,2]. However, the number of denture users is unlikely to decrease dramatically, and the importance of dentures has been increasing worldwide [3]. Oral cavity microorganisms have been implicated in denture stomatitis [4,5], aspiration pneumonia [6,7], and chronic obstructive pulmonary disease [8]. Dentures can harbor several pathogens [9,10], necessitating denture cleaning to prevent the associated diseases [11][12][13]. Denture cleaners help to remove denture plaques/calculi containing oral bacteria [14,15], deposits, and stains [16,17]. However, research about the effects of these cleaners on other target substances has been limited. Denture adhesives, used to increase the retention and stability of removable prostheses, have not been enthusiastically received by dental professionals, but have recently been approved for appropriate use [3,18,19]. Denture adhesives are categorized according to their physical form as powders, creams, sheets, and tapes. Cream adhesives, composed of carboxymethyl cellulose (CMC) and methoxyethylene maleic anhydride copolymer salt as hydrophilic components and liquid paraffin and petrolatum as hydrophobic compounds, are popular; however, they are difficult to remove from dentures and oral mucosa owing to their high viscosity [20][21][22].To remove cream adhesives, manufacturers recommend the use of gauze or tissue paper to roughly remove the adhesive, followed by mechanical cleaning using a denture brush under running water; however, existing studies suggest that these techniques are insuffi-J Prosthodont Res. 2022; **(**):