Crosstalk between circadian rhythms and the microbiota

Pearson, James A.; Wong, F. Susan; Li, Wen

doi:10.1111/imm.13278

Cited by 38 publications

(31 citation statements)

References 188 publications

(431 reference statements)

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“…In the mammalian gut -by far the most studied host-microbiome interface -there is a complex interplay between immune factors that shape microbial communities and, conversely, microbiota profoundly affecting immune system development and maintenance 14,15 . Mammal gut microbiome daily rhythms may themselves play a role in host circadian health 60,61 . However, in other tissues, and particularly for non-mammalian vertebrates, host immune-microbiome connectivity and circadian dynamics remains poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Circadian dynamics of the teleost skin immune-microbiome interface

Ellison

Wilcockson

Cable

2021

Preprint

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Circadian rhythms of host immune activity and their microbiomes are likely pivotal to health and disease resistance. The integration of chronotherapeutic approaches to disease mitigation in managed animals, however, is yet to be realised. In aquaculture, light manipulation is commonly used to enhance growth and control reproduction but may have unknown negative consequences for animal health. Infectious diseases are a major barrier to sustainable aquaculture and understanding the circadian dynamics of fish immunity and crosstalk with the microbiome is urgently needed. We demonstrate daily rhythms in fish skin immune expression and microbiomes, that are modulated by photoperiod and parasitic infection. We identify putative associations of host clock and immune gene profiles with microbial composition. Our results suggest circadian perturbation that shifts the magnitude and timing of immune and microbiota activity, is detrimental to fish health. This study represents a valuable foundation for investigating the utility of chronotherapies in aquaculture, and more broadly contributes to our understanding of circadian health in vertebrates.

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Section: Discussionmentioning

confidence: 99%

Circadian dynamics of the teleost skin immune-microbiome interface

Ellison

Wilcockson

Cable

2021

Preprint

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“…Although the mode of action of phototherapy with full-spectrum light has not been fully elucidated, it may regulate proinflammatory cytokine signaling and oxidative stress and maintain optimal levels of vitamin D 3 and healthy microbiota composition. Interestingly, accumulating evidence suggests the impact of microbiota on circadian rhythms and human health [42]. These evidences suggest the therapeutic potential of phototherapy with full-spectrum light in many diseases associated with vitamin D 3 insufficiency/deficiency, circadian rhythm disruption and gut dysbiosis.…”

Section: Phototherapy For Active and Healthy Aging: History And Current Applicationsmentioning

confidence: 99%

Sunlight Exposure and Phototherapy: Perspectives for Healthy Aging in an Era of COVID-19

Nakano

Chiang

Chen

et al. 2021

IJERPH

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Most humans depend on sunlight exposure to satisfy their requirements for vitamin D3. However, the destruction of the ozone layer in the past few decades has increased the risk of skin aging and wrinkling caused by excessive exposure to ultraviolet (UV) radiation, which may also promote the risk of skin cancer development. The promotion of public health recommendations to avoid sunlight exposure would reduce the risk of skin cancer, but it would also enhance the risk of vitamin D3 insufficiency/deficiency, which may cause disease development and progression. In addition, the ongoing global COVID-19 pandemic may further reduce sunlight exposure due to stay-at-home policies, resulting in difficulty in active and healthy aging. In this review article, we performed a literature search in PubMed and provided an overview of basic and clinical data regarding the impact of sunlight exposure and vitamin D3 on public health. We also discuss the potential mechanisms and clinical value of phototherapy with a full-spectrum light (notably blue, red, and near-infrared light) as an alternative to sunlight exposure, which may contribute to combating COVID-19 and promoting active and healthy aging in current aged/superaged societies.

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“…Gastrointestinal microorganisms play key regulatory roles in host physiological processes including metabolic immunity and neuroendocrine pathways [25][26][27]. In addition, accumulating evidence has demonstrated that host circadian rhythms modulate microbial oscillations, and vice versa [28,29].…”

Section: Introductionmentioning

confidence: 99%

Simulated Space Environmental Factors of Weightlessness, Noise and Low Air Pressure Differentially Affect the Circadian Rhythm and Gut Microbiome

Ma¹,

Gan²,

Zhao³

et al. 2021

Preprint

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Backgroundhe circadian clock extensively regulates physiology and behavior. In space, the astronauts encounter many environmental factors that are dramatically different from those on earth, however, the effects of these factors on circadian rhythms and the mechanisms remain largely unknown. The present study aimed to investigate the changes in the mouse circadian rhythm and gut microbiome under simulated space capsule conditions, including microgravity, noise and low atmospheric pressure.ResultsNoise and low atmospheric pressure were loaded in the capsule while the conditions in the animal room remained constant. The mice in the capsule showed disturbed locomotor rhythms and faster adaptation to a 6-h phase advance. RNA sequencing of hypothalamus samples revealed that microgravity simulated by hind limb unloading (HU) and exposure to noise and low atmospheric pressure led to decreases in the quantities of differentially expressed genes (DEGs), including circadian clock genes. Changes in the rhythmicity of genes implicated in pathways of cardiovascular deconditioning and more concentrated circadian phases were found under HU or noise and low atmospheric pressure. Furthermore, 16S rRNA sequencing revealed dysbiosis in the gut microbiome, and noise and low atmospheric pressure may repress the temporal discrepancy in the microbiome community structure induced by microgravity. Changes in diel oscillation were observed in a number of gut bacteria with critical physiological consequences in metabolism and immunodefense.ConclusionsOur data demonstrate that in addition to microgravity, exposure to noise and low atmospheric pressure affect the robustness of circadian rhythms and the community structure of the gut microbiome, and these factors may interfere with each other in their adaptation to respective conditions. These findings are important to further our understanding of the alteration of circadian rhythms in the space complex environment.

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Crosstalk between circadian rhythms and the microbiota

Cited by 38 publications

References 188 publications

Circadian dynamics of the teleost skin immune-microbiome interface

Circadian dynamics of the teleost skin immune-microbiome interface

Sunlight Exposure and Phototherapy: Perspectives for Healthy Aging in an Era of COVID-19

Simulated Space Environmental Factors of Weightlessness, Noise and Low Air Pressure Differentially Affect the Circadian Rhythm and Gut Microbiome

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