Crosstalk between dietary pomegranate and gut microbiota: evidence of health benefits

Yin, Yue; Martínez, R.; Zhang, Wangang; Estévez, Mario

doi:10.1080/10408398.2023.2219763

Cited by 6 publications

(3 citation statements)

References 162 publications

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“…Ellagitannins have been investigated for their anti-inflammatory, antibacterial, and prebiotic effects [9][10][11]26], but their potential role in acne is poorly investigated.…”

Section: Discussionmentioning

confidence: 99%

Investigation into the Anti-Acne Effects of Castanea sativa Mill Leaf and Its Pure Ellagitannin Castalagin in HaCaT Cells Infected with Cutibacterium acnes

Piazza,

Martinelli,

Maranta

et al. 2024

IJMS

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Acne vulgaris is a prevalent skin disorder affecting many young individuals, marked by keratinization, inflammation, seborrhea, and colonization by Cutibacterium acnes (C. acnes). Ellagitannins, known for their antibacterial and anti-inflammatory properties, have not been widely studied for their anti-acne effects. Chestnut (Castanea sativa Mill., C. sativa), a rich ellagitannin source, including castalagin whose acne-related bioactivity was previously unexplored, was investigated in this study. The research assessed the effect of C. sativa leaf extract and castalagin on human keratinocytes (HaCaT) infected with C. acnes, finding that both inhibited IL-8 and IL-6 release at concentrations below 25 μg/mL. The action mechanism was linked to NF-κB inhibition, without AP-1 involvement. Furthermore, the extract displayed anti-biofilm properties and reduced CK-10 expression, indicating a potential role in mitigating inflammation, bacterial colonization, and keratosis. Castalagin’s bioactivity mirrored the extract’s effects, notably in IL-8 inhibition, NF-κB inhibition, and biofilm formation at low μM levels. Other polyphenols, such as flavonol glycosides identified via LC-MS, might also contribute to the extract’s biological activities. This study is the first to explore ellagitannins’ potential in treating acne, offering insights for developing chestnut-based anti-acne treatments pending future in vivo studies.

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“…Ellagitannins have been investigated for their anti-inflammatory, antibacterial, and prebiotic effects [9][10][11]26], but their potential role in acne is poorly investigated.…”

Section: Discussionmentioning

confidence: 99%

Investigation into the Anti-Acne Effects of Castanea sativa Mill Leaf and Its Pure Ellagitannin Castalagin in HaCaT Cells Infected with Cutibacterium acnes

Piazza,

Martinelli,

Maranta

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…These alterations seem to be induced by gut microbiota dysbiosis and local inflammation, suggesting the potential role of the diet on PC [133]. Different in vivo studies have focused attention on how PPE reshapes the gut microbiota thanks to the countless properties exerted by the phytochemical compounds contained therein, thus constituting a possible adjuvant therapy for PC [134].…”

Section: Pomegranate and Prostate Cancermentioning

confidence: 99%

Healthy Effects of Pomegranate (Punica granatum L.) in Internal Medicine and Dentistry

Marrone,

Basilicata,

Di Lauro

et al. 2024

Applied Sciences

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Punica granatum L., commonly known as pomegranate, is a typical fruit of Asia, Mediterranean countries, the Middle East and the USA. While in ancient times pomegranate was considered an ornamental plant, nowadays numerous scientific studies have highlighted its antioxidant and anti-radical activities, making it a “superfood”. Pomegranate presents a high content of natural bioactive compounds (NBCs), and its consumption appears to exert numerous healthy effects, in particular, in several pathological conditions as metabolic syndrome, cancer, nephrolithiasis, urinary tract infections and neurodegenerative diseases. Moreover, recent studies have pointed out the possible beneficial action of pomegranate on oral health. For these reasons, the utility of pomegranate in internal medicine and dentistry represents a promising field, as it could enable the development of innovative natural adjuvant therapies and empower standard pharmaceutical therapies.

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“…These alterations seem to be induced by gut microbiota dysbiosis and local inflammation, suggesting the potential role of the diet on PC [115]. Different in vivo studies have focused the attention on how PPE reshapes the gut microbiota thanks to its countless properties, exert by phytochemicals compounds contained therein, and thus costituting a possible adjuvant therapy for PC [116].…”

Section: Pomegranate and Prostate Cancermentioning

confidence: 99%

Healthy Effects of Pomegranate (<em>Punica granatum</em> L.) in Internal Medicine and Dentistry

Marrone,

Basilicata,

Di Lauro

et al. 2024

Preprint

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Punica granatum L., commonly known as pomegranate, is a typical fruit of Asia, Mediterranean countries, Middle East and USA areas. While in the ancient time pomegranate was considered an ornamental plant, nowadays numerous scientific studies have highlighted its antioxidant and anti-radical activities, up to consider pomegranate as a “superfood”. Pomegranate presents a high content of natural bioactive compounds (NBCs) and its consumption appears to exert numerous healthy beneficial effects, in particular, in several pathological conditions, namely in patients affected by metabolic syndrome, cancer, nephrolithiasis, urinary tract infections and neurodegenerative diseases. Moreover, recent studies pointed out the possible beneficial action of pomegranate on oral health. For these reasons, the utility of pomegranate in internal medicine and in dentistry represents a promising field, as it could permit the development of innovative natural adjuvant therapies, able to empower the standard pharmaceutical therapies.

show abstract

Crosstalk between dietary pomegranate and gut microbiota: evidence of health benefits

Cited by 6 publications

References 162 publications

Investigation into the Anti-Acne Effects of Castanea sativa Mill Leaf and Its Pure Ellagitannin Castalagin in HaCaT Cells Infected with Cutibacterium acnes

Investigation into the Anti-Acne Effects of Castanea sativa Mill Leaf and Its Pure Ellagitannin Castalagin in HaCaT Cells Infected with Cutibacterium acnes

Healthy Effects of Pomegranate (Punica granatum L.) in Internal Medicine and Dentistry

Healthy Effects of Pomegranate (<em>Punica granatum</em> L.) in Internal Medicine and Dentistry

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