Crosstalk between imbalanced gut microbiota caused by antibiotic exposure and rotavirus replication in the intestine

Li, Yuhui; Wu, Yifan; Wu, Jie; Yu, Lingling; Li, Xin; Xie, Ke; Zhang, Mingyi; Ren, Lingling; Ji, Yanli; Liu, Yehao

doi:10.1016/j.heliyon.2022.e12718

Cited by 3 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar trends were also observed in norovirus infection [7]. A disrupted microbiota was associated with a higher level of lipopolysaccharide (LPS), which could increase viral stabilization [124]. Mechanistically, the interaction between gut microbiota and viruses seems to stabilize enteric viruses, enhance their adhesion to host cells, inhibit antibody production, and create a conducive environment for viral replication and immune evasion [125].…”

Section: Interaction Of Gut Microbiome and Enteric Virusesmentioning

confidence: 67%

“…Mechanistically, the interaction between gut microbiota and viruses seems to stabilize enteric viruses, enhance their adhesion to host cells, inhibit antibody production, and create a conducive environment for viral replication and immune evasion [125]. Conversely, several studies found that antibiotic-treated or germ-free animal models have higher rotavirus replication and more severe symptoms, which can be mitigated by FMT [124,126,127]. An elevated abundance of Akkermansia and a reduced abundance of Faecalibacterium were correlated with higher levels of viral antibodies [128].…”

Section: Interaction Of Gut Microbiome and Enteric Virusesmentioning

confidence: 99%

“…Enteric virus infection might alter gut microbiota composition. Disrupted gut microbiota was observed both in rotavirus-and norovirus-infected patients with lower richness and diversity [9,124,127,132,133]. The gut microbiota in rotavirus carriers were dominated by antibiotic-resistant Gram-negative bacteria [124].…”

Section: Interaction Of Gut Microbiome and Enteric Virusesmentioning

confidence: 99%

“…Disrupted gut microbiota was observed both in rotavirus-and norovirus-infected patients with lower richness and diversity [9,124,127,132,133]. The gut microbiota in rotavirus carriers were dominated by antibiotic-resistant Gram-negative bacteria [124]. The abundance of probiotics was extremely low and pathogenic bacteria were increased in rotavirus infected patients [124].…”

Section: Interaction Of Gut Microbiome and Enteric Virusesmentioning

confidence: 99%

“…The gut microbiota in rotavirus carriers were dominated by antibiotic-resistant Gram-negative bacteria [124]. The abundance of probiotics was extremely low and pathogenic bacteria were increased in rotavirus infected patients [124]. The Bacteroidetes and Proteobacteria increased while Firmicutes and Bacteroidetes decreased in rotavirus infected adults compared to healthy individuals [124].…”

Section: Interaction Of Gut Microbiome and Enteric Virusesmentioning

confidence: 99%

See 4 more Smart Citations

Therapeutic Approach Targeting Gut Microbiome in Gastrointestinal Infectious Diseases

Han,

Min,

Pang

et al. 2023

IJMS

View full text Add to dashboard Cite

While emerging evidence highlights the significance of gut microbiome in gastrointestinal infectious diseases, treatments like Fecal Microbiota Transplantation (FMT) and probiotics are gaining popularity, especially for diarrhea patients. However, the specific role of the gut microbiome in different gastrointestinal infectious diseases remains uncertain. There is no consensus on whether gut modulation therapy is universally effective for all such infections. In this comprehensive review, we examine recent developments of the gut microbiome’s involvement in several gastrointestinal infectious diseases, including infection of Helicobacter pylori, Clostridium difficile, Vibrio cholerae, enteric viruses, Salmonella enterica serovar Typhimurium, Pseudomonas aeruginosa Staphylococcus aureus, Candida albicans, and Giardia duodenalis. We have also incorporated information about fungi and engineered bacteria in gastrointestinal infectious diseases, aiming for a more comprehensive overview of the role of the gut microbiome. This review will provide insights into the pathogenic mechanisms of the gut microbiome while exploring the microbiome’s potential in the prevention, diagnosis, prediction, and treatment of gastrointestinal infections.

show abstract

Section: Interaction Of Gut Microbiome and Enteric Virusesmentioning

confidence: 67%

Section: Interaction Of Gut Microbiome and Enteric Virusesmentioning

confidence: 99%

Section: Interaction Of Gut Microbiome and Enteric Virusesmentioning

confidence: 99%

Section: Interaction Of Gut Microbiome and Enteric Virusesmentioning

confidence: 99%

Section: Interaction Of Gut Microbiome and Enteric Virusesmentioning

confidence: 99%

See 3 more Smart Citations

Therapeutic Approach Targeting Gut Microbiome in Gastrointestinal Infectious Diseases

Han,

Min,

Pang

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

A review on the alternatives to antibiotics and the treatment of antibiotic pollution: Current development and future prospects

Yang,

Li,

Yao

et al. 2024

Science of The Total Environment

View full text Add to dashboard Cite

Effects of Isalo scorpion cytotoxic peptide on growth, immune performance, and intestinal flora of yellow-feathered broilers

Wang,

Zhu,

et al. 2024

Front. Vet. Sci.

View full text Add to dashboard Cite

IntroductionThis study aimed to investigate the effects of Isalo scorpion cytotoxic peptide (IsCT) on the growth performance, immune function, and gut microbiota of yellow-feathered broilers.MethodsThe experiment involved supplementing a corn-soybean meal-based diet with various dietary levels of IsCT. The experiment adopted a completely randomized design. A total of 240 one-day-old yellow-feathered broilers were randomly divided into six groups: a control group (CON), a chlortetracycline group (CTC), and four groups receiving a basal diet with 50, 100, 150, or 200 mg/ kg IsCT (IsCT50, IsCT100, IsCT150, and IsCT200). The trial period lasted 60 days.ResultsThe results showed that the average final body weight and average daily weight gain of the IsCT150 and IsCT200 groups were significantly higher than those of the CON group (p < 0.05). Compared to the CTC group, the average daily feed intake in group III was significantly lower (p < 0.05). The feed conversion ratios of the IsCT150 and IsCT200 groups were significantly lower than those of the IsCT50 and CON groups (p < 0.05). Albumin levels in the CTC and IsCT150 groups were significantly higher than those in the CON, IsCT100, and IsCT50 groups. Alanine transaminase levels in the IsCT150 group were significantly lower than those in the IsCT50, IsCT200, CON, and CTC groups (p < 0.05), but there was no significant difference compared with the IsCT100 group (p < 0.05). IgA levels in the IsCT150, IsCT200, and CTC groups were significantly higher than those in the IsCT50 group (p < 0.05). IgG levels in the CTC, IsCT100, IsCT150, and IsCT200 groups were significantly higher than those in the IsCT50 and CON groups (p < 0.05). 16S rRNA sequencing indicated significant differences in the caecal microbiota between the IsCT and CON groups (p < 0.05). The abundance of Bacteroidetes increased, whereas that of Firmicutes decreased in the IsCT groups; however, the difference was not significant (p < 0.05). The relative abundances of Actinobacteriota and Patescibacteria were significantly different in the IsCT100 group (p < 0.05).DiscussionIn conclusion, supplementing the basal diet with IsCT improved growth performance, immune function, and gut microbiota of yellow-feathered broilers at an optimal supplementation level of 150 mg/kg.

show abstract

Crosstalk between imbalanced gut microbiota caused by antibiotic exposure and rotavirus replication in the intestine

Cited by 3 publications

References 34 publications

Therapeutic Approach Targeting Gut Microbiome in Gastrointestinal Infectious Diseases

Therapeutic Approach Targeting Gut Microbiome in Gastrointestinal Infectious Diseases

A review on the alternatives to antibiotics and the treatment of antibiotic pollution: Current development and future prospects

Effects of Isalo scorpion cytotoxic peptide on growth, immune performance, and intestinal flora of yellow-feathered broilers

Contact Info

Product

Resources

About