2024
DOI: 10.1186/s12943-024-01977-1
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Crosstalk between metabolism and cell death in tumorigenesis

Shichao Yang,
Caden Hu,
Xiaomei Chen
et al.

Abstract: It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to such an abnormally rapid proliferation rate, cancer cells constantly encounter the limits of insufficient oxygen and nutrient supplies. To satisfy their growth needs and resist adverse environmental events, tumor cells modify the metabolic pathways to produce both extra energies and substances required for rapid growth. Realizing the metabolic characters special for tumor cells will be helpful for eliminating them du… Show more

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Cited by 15 publications
(3 citation statements)
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“…Altered levels of bile acid conjugates, such as glycoursodeoxycholic acid sulfate and taurochenodeoxycholate, may disrupt homeostatic processes ( Chiang, 2013 ). These disrupted homeostatic processes, in turn, regulate metabolism and cell death pathways, thereby influencing the tumor microenvironment and playing a crucial role in tumorigenesis and tumor progression ( Yang et al, 2024 ). Simultaneously, metabolites like 3-ethylcatechol sulfate, related to catechol metabolism, could influence oxidative stress and hormonal imbalances ( Chainy and Sahoo, 2020 ).…”
Section: Discussionmentioning
confidence: 99%
“…Altered levels of bile acid conjugates, such as glycoursodeoxycholic acid sulfate and taurochenodeoxycholate, may disrupt homeostatic processes ( Chiang, 2013 ). These disrupted homeostatic processes, in turn, regulate metabolism and cell death pathways, thereby influencing the tumor microenvironment and playing a crucial role in tumorigenesis and tumor progression ( Yang et al, 2024 ). Simultaneously, metabolites like 3-ethylcatechol sulfate, related to catechol metabolism, could influence oxidative stress and hormonal imbalances ( Chainy and Sahoo, 2020 ).…”
Section: Discussionmentioning
confidence: 99%
“…The tumor microenvironment is also implicated in the metabolic regulation of cell death, suggesting that modulating cancer cell metabolism could be a viable and effective strategy to regulate tumorigenesis [94]. The characterization of metabolic reprogramming in the tumor microenvironment is becoming increasingly crucial in cancer research and patient care [95].…”
Section: The Significance Of Eaa Supplementationmentioning
confidence: 99%
“…Altered levels of bile acid conjugates, such as glycoursodeoxycholic acid sulfate and taurochenodeoxycholate, may disrupt homeostatic processes (Chiang, 2013). These disrupted homeostatic processes, in turn, regulate metabolism and cell death pathways, thereby influencing the tumor microenvironment and playing a crucial role in tumorigenesis and tumor progression (Yang et al, 2024). Simultaneously, metabolites like 3-ethylcatechol sulfate, related to Frontiers in Genetics frontiersin.org catechol metabolism, could influence oxidative stress and hormonal imbalances (Chainy and Sahoo, 2020).…”
Section: Discussionmentioning
confidence: 99%