Crosstalk between sIgA-Coated Bacteria in Infant Gut and Early-Life Health

Ding, Mengfan; Yang, Bo; Ross, R. Paul; Stanton, Catherine; Zhao, Jianxin; Zhang, Hao

doi:10.1016/j.tim.2021.01.012

Cited by 40 publications

(29 citation statements)

References 77 publications

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“…These results suggest that stroke disrupts the intestinal mechanical barrier in mice. Intestinal SigA is an important component of the intestinal mucosal immune barrier, and MUC2 is a major component of the intestinal mucus layer (34,46,47). It has been reported that alterations in intestinal MUC2 and microbial diversity are closely linked with critical intestinal pathologies (48).…”

Section: Discussionmentioning

confidence: 99%

Dynamic Process of Secondary Pulmonary Infection in Mice With Intracerebral Hemorrhage

Zhang

Huang

et al. 2021

Front. Immunol.

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Stroke is a common central nervous system disease in clinical practice. Stroke patients often have infectious complications, such as pneumonia and infections of the urinary tract and gastrointestinal tract. Although it has been shown that translocation of the host gut microbiota to the lungs and immune dysfunction plays a vital role in the development of infection after ischemic stroke, the occurrence and mechanism of pulmonary infection at different time points after hemorrhagic cerebral remain unclear. In this study, the changes in the immune system and intestinal barrier function in mice during disease development were investigated at 1 day (M 1 d), 3 days (M 3 d) and 7 days (M 7 d) following hemorrhagic stroke to clarify the mechanism of secondary pulmonary infection. The experimental results revealed that after hemorrhagic stroke, model mice showed increased brain damage from day 1 to 3, followed by a trend of brain recovery from day 3 to 7 . After hemorrhagic stroke, the immune system was disturbed in model mice. Significant immunosuppression of the peripheral immune system was observed in the M 3 d group but improved in the M 7 d group. Staining of lung tissues with hematoxylin and eosin (H&E) and for inflammatory factors revealed considerable disease and immune disorders in the M 7 d group. Stroke seriously impaired intestinal barrier function in mice and significantly changed the small intestine structure. From 1 to 7 d after stroke, intestinal permeability was increased, whereas the levels of markers for intestinal tight junctions, mucus and immunoglobulin A were decreased. Analysis based on 16S rRNA suggested that the microflora in the lung and ileum was significantly altered after stroke. The composition of microflora in lung and ileum tissue was similar in the M 7d group, suggesting that intestinal bacteria had migrated to lung tissue and caused lung infection at this time point after hemorrhagic stroke. In stroke mice, the aggravation of intestinal barrier dysfunction and immune disorders after intracerebral hemorrhage, promoted the migration of enteric bacteria, and increased the risk of pneumonia poststroke. Our findings reveal the dynamic process of infection after hemorrhagic stroke and provide clues for the optimal timing of intervention for secondary pulmonary infection in stroke patients.

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Section: Discussionmentioning

confidence: 99%

Dynamic Process of Secondary Pulmonary Infection in Mice With Intracerebral Hemorrhage

Zhang

Huang

et al. 2021

Front. Immunol.

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“…27 SIgA's other activities include toxin neutralization, inhibition of virus uptake, suppression of bacterial virulence factors, and interference with bacterial division processes ("enchained growth"). 28,29 In addition to its effects against pathogens, SIgA also shapes the composition of the commensal microbiota 30 and is postulated to play an important role in maintaining stability and microbial diversity on mucosal surfaces. 31 However, the precise mechanisms by which SIgA influences the host microbiome remains unclear.…”

Section: Secretory Iga (Siga) In Mucosal Immunitymentioning

confidence: 99%

The prospect of orally administered monoclonal secretory IgA (SIgA) antibodies to prevent enteric bacterial infections

Richards

Baranova

Mantis

2021

Human Vaccines & Immunotherapeutics

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Eliminating diarrheal diseases as a leading cause of childhood morbidity and mortality in low-and middleincome countries (LMICs) will require multiple intervention strategies. In this review, we spotlight a series of preclinical studies investigating the potential of orally administered monoclonal secretory IgA (SIgA) antibodies (MAbs) to reduce disease associated with three enteric bacterial pathogens: Campylobacter jejuni, enterotoxigenic Escherichia coli (ETEC), and invasive Salmonella enterica serovar Typhimurium. IgA MAbs targeting bacterial surface antigens (flagella, adhesins, and lipopolysaccharide) were generated from mice, humanized mice, and human tonsillar B cells. Recombinant SIgA1 and/or SIgA2 derivates of those MAbs were purified from supernatants following transient transfection of 293 cells with plasmids encoding antibody heavy and light chains, J-chain, and secretory component (SC). When administered to mice by gavage immediately prior to (or admixed with) the bacterial challenge, SIgA MAbs reduced infection C. jejuni, ETEC, and S. Typhimurium infections. Fv-matched IgG1 MAbs by comparison were largely ineffective against C. jejuni and S. Typhimurium under the same conditions, although they were partially effective against ETEC. While these findings highlight future applications of orally administered SIgA, the studies also underscored the fundamental challenges associated with using MAbs as prophylactic tools against enteric bacterial diseases.

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“…In this context, there is robust scientific evidence demonstrating that inheritance of bifidobacteria occurs by vertical transmission from mother to her newborn [10][11][12][13] . Recently, detailed cataloging of bifidobacterial communities residing in the gut microbiota of mothers and their corresponding babies highlighted the occurrence of identical bifidobacterial strains shared by mother-newborn dyads [10,12,14,15] . If this bacterial transmission route is interrupted, for example as a consequence of delivery by cesarian section, the gut microbiota of the newborn has been shown to be delayed in becoming dominated by bifidobacteria.…”

Section: The Human Gut and The Origin Of Bifidobacteriamentioning

confidence: 99%

Bifidobacteria: insights into the biology of a key microbial group of early life gut microbiota

Turroni¹,

Sinderen²,

Ventura³

2021

MRR

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Crosstalk between sIgA-Coated Bacteria in Infant Gut and Early-Life Health

Cited by 40 publications

References 77 publications

Dynamic Process of Secondary Pulmonary Infection in Mice With Intracerebral Hemorrhage

Dynamic Process of Secondary Pulmonary Infection in Mice With Intracerebral Hemorrhage

The prospect of orally administered monoclonal secretory IgA (SIgA) antibodies to prevent enteric bacterial infections

Bifidobacteria: insights into the biology of a key microbial group of early life gut microbiota

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