Crosstalk between TRPV1 and immune regulation in Fuchs endothelial corneal dystrophy

Cai, Yuchen; Chen, Jin; Sun, Hao; Zhou, Tianyi; Cai, Xueyao; Fu, Yao

doi:10.1016/j.clim.2023.109701

Cited by 3 publications

(1 citation statement)

References 66 publications

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“…Further, transient receptor potential (TRP) ion channels are a superfamily of proteins that have been identified in sensing and transmitting a wide range of stimuli including osmotic changes, cell membrane curvature, and mechanical stress to regulate volume regulation, calcium signaling and migration ( Canales et al, 2019 ; Nilius and Owsianik, 2011 ; Pedersen and Nilius, 2007 ; Yin and Kuebler, 2010 ). Indeed, TRP channels have been implicated in the pathophysiology of corneal pain ( Fakih et al, 2022 ), dry eye disease ( Fakih et al, 2022 ), inflammatory fibrosis ( Okada et al, 2021 ), and FECD ( Cai et al, 2023 ). As mechanosensors changes their conformation, they induce mechanical shifts that propagate a signaling cascade through interacting linker proteins such as vinculin, talin, and kindlin onto effector proteins like RhoA, Rho associated coiled-coil kinase (ROCK), and actin ( Astudillo, 2020 ).…”

Section: An Overview Of Mechanotransductionmentioning

confidence: 99%

Squishy matters – Corneal mechanobiology in health and disease

Thomasy,

Leonard,

Greiner

et al. 2024

Progress in Retinal and Eye Research

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Section: An Overview Of Mechanotransductionmentioning

confidence: 99%

Squishy matters – Corneal mechanobiology in health and disease

Thomasy,

Leonard,

Greiner

et al. 2024

Progress in Retinal and Eye Research

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TRPV: An emerging target in glaucoma and optic nerve damage

Zhang,

Wang,

2024

Experimental Eye Research

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Deciphering the Genetic Architecture of Chronic Obstructive Pulmonary Disease (COPD): Insights from the UK Biobank and Mendelian Randomization Analysis

Cui,

Quan,

Zhang

et al. 2024

Preprint

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Genetic susceptibility plays a crucial role in the development of Chronic Obstructive Pulmonary Disease (COPD), however, the research on genetic susceptibility genes for COPD is currently limited by incomplete understanding and insufficient identification of all contributory genetic factors. To address this issue, we conducted a prospective analysis in the UK Biobank study and Mendelian randomization (MR) analysis to unveil the causal relationship of potential genetic factors in COPD. Our findings underscore the involvement of key genes NME3, MPZL3, GNAQ, and ARL5B in COPD occurrence. Notably, the presence of the NME3 (0.998 ;0.997 −0.999; P = 0.004) and MPZL3 (0.999 ;0.998 −1.000; P = 0.048) potentially confers a reduced risk of COPD, while GNAQ (1.002 ;1.001 −1.004; P = 0.010) and ARL5B (1.004 ;1.000 −1.008; P = 0.040) are associated with an elevated risk of COPD. Multi-omics analysis showed that the expression levels of these key genes were highly correlated, either positively or negatively, with various COPD-related immune cell infiltrations, immune factor expression levels (immunomodulators, chemokines, and cellular receptors), and expression levels of disease genes associated with COPD. Additionally, we analyzed the expression levels of these key genes at the single-cell level, their involved signaling pathways, and regulatory networks to preliminarily reveal their potential molecular mechanisms in regulating COPD. Finally, potential drugs for treating COPD, such as Fostamatinib, MEK1-2-inhibitor, QL-XI-92, TWS-119, and VER-155008, were identified through drug targeting predictions using the Connectivity Map database.

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Crosstalk between TRPV1 and immune regulation in Fuchs endothelial corneal dystrophy

Cited by 3 publications

References 66 publications

Squishy matters – Corneal mechanobiology in health and disease

Squishy matters – Corneal mechanobiology in health and disease

TRPV: An emerging target in glaucoma and optic nerve damage

Deciphering the Genetic Architecture of Chronic Obstructive Pulmonary Disease (COPD): Insights from the UK Biobank and Mendelian Randomization Analysis

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