Crosstalk between Wnt/β-catenin signaling pathway and DNA damage response in cancer: a new direction for overcoming therapy resistance

Abstract

Wnt signaling plays an important role in regulating the biological behavior of cancers, and many drugs targeting this signaling have been developed. Recently, a series of research have revealed that Wnt signaling could regulate DNA damage response (DDR) which is crucial for maintaining the genomic integrity in cells and closely related to cancer genome instability. Many drugs have been developed to target DNA damage response in cancers. Notably, different components of the Wnt and DDR pathways are involved in crosstalk, forming a complex regulatory network and providing new opportunities for cancer therapy. Here, we provide a brief overview of Wnt signaling and DDR in the field of cancer research and review the interactions between these two pathways. Finally, we also discuss the possibility of therapeutic agents targeting Wnt and DDR as potential cancer treatment strategies.

Sinensetin suppresses breast cancer cell progression via Wnt/β-catenin pathway inhibition

“…The activation of Wnt/β-catenin signaling pathway can promote malignant phenotype of cancer ( 34 , 35 ). The Wnt/β-catenin signaling pathway is involved in regulating the effect of drugs derived from natural products ( 36 , 37 ).…”

Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic Utility

“…Moreover, although no direct association has been established between RYK and DNA damage or the PI3K/AKT signaling pathway, previous research has reported correlations with the WNT signaling pathways. Components of the WNT pathways, including APC, Axin, FZD, and GSK-3β, have been demonstrated to directly regulate the DNA damage response (DDR) [57]. In breast cancer, it has been observed that the protein phosphatase PP2A of the PI3K/AKT signaling pathway activates β-catenin, thereby promoting its transcriptional activity [58].…”