Crosstalk between xanthine oxidase (XO) inhibiting and cancer chemotherapeutic properties of comestible flavonoids- a comprehensive update

Rahaman, Md Sohanur; Siraj, Md Afjalus; Islam, Md. Arman; Shanto, Prayas Chakma; Islam, Ordha; Islam, Abu Zafor Md. Touhidul; Simal-Gándara, Jesús

doi:10.1016/j.jnutbio.2022.109147

Cited by 8 publications

(3 citation statements)

References 517 publications

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“…Xanthine oxidase (XOD, EC 1.17.3.2) is the key enzyme in purine metabolism that converts hypoxanthine and xanthine into uric acid while producing H 2 O 2 in living organisms . Inhibiting XOD activity is an effective strategy to reduce uric acid production, making it a promising target for hyperuricemia treatment . Although allopurinol, febuxostat, and other drugs that inhibit XOD activity are being used in clinical trials to treat hyperuricemia, they have inevitable side effects that can endanger patients’ health. , Therefore, there is still a need to develop more potent drug candidates with reduced toxicity to treat hyperuricemia.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Purification, and Identification of Novel Feather Keratin-Derived Peptides with Antioxidative and Xanthine Oxidase Inhibitory Activities

Pei

Zhang

et al. 2023

J. Agric. Food Chem.

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Feather keratin is an underappreciated protein resource of high quality, with limited bioavailability, and it urgently requires eco-friendly methods to enhance its value. Here, we report on the preparation, purification, and identification of novel peptides with antioxidant and xanthine oxidase (XOD) inhibitory activities from fermented feather broth, using Bacillus licheniformis 8-4. Two peptides, namely, DLCRPCGPTPLA (DA-12) and ANSCNEPCVR (AR-10), displayed remarkable 1,1-diphenyl-2picrylhydrazyl (DPPH) radical and 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging abilities with half-maximal inhibitory concentrations (IC 50 ) values of 0.048, 0.034, and 0.95, 0.84 mg/mL, respectively. These values exceed those of the previously reported feather keratin-derived antioxidant peptides. Another peptide, GNQQVHLQSQDM (GM-12), demonstrated XOD activity inhibition, with an IC 50 value of 12.15 mg/mL, and it quenched the fluorescence of XOD. Furthermore, after simulating gastrointestinal digestion, DA-12, AR-10, and GM-12 retained their biological activities. Meanwhile, DA-12 and GM-12 showed an unexpected synergistic inhibition on XOD activity accompanied by fluorescence quenching. This study provides new insights into the potential applications of feather keratin, including functionalized feed with antioxidative and antigout (antihyperuricemia) activities.

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Section: Introductionmentioning

confidence: 99%

Preparation, Purification, and Identification of Novel Feather Keratin-Derived Peptides with Antioxidative and Xanthine Oxidase Inhibitory Activities

Pei

Zhang

et al. 2023

J. Agric. Food Chem.

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“…[100], 626 [41], 627 [10], 723 [6], 661 [3], 1251 [3] MS 2 [625]: 300 [100], 301 [73], 445 [33], 505 [17], 271 [16], 463 [11], 355 [9], 255 [8], 343 [8], 299 [6], 325 [5], 273 [4], 409 [4], 427 [4], 367 [3] MS 3 [625 → 300]: 271 [100], 255 [61], 272 [12], 254 [7], 243 [3] MS 2 [723]: 625 [100], 399 [34], 437 [21], 687 [21], 685 [21]. 437 [21] MS 3 [723 → 625]: 300 [100], 301 [76], 445 [40], 271 [17], 505 [17], 463 [13] MS 2 [23], 211 [16],…”

Section: Compounds Ms (M/z) [Relative Intensity] Ms N (M/z) [Relative...mentioning

confidence: 99%

“…If uric acid crystals are overproduced, the inflammatory response can be triggered, resulting in joint arthritis known as gout. XO is also responsible for generating oxygen-derived free radicals that may result in an imbalance between pro-oxidants and antioxidants, causing some people to be more prone to diseases such as cancer [23]. Anti-gout drugs (e.g., allopurinol), acting as inhibitors of XO activity, may have some side effects such as hepatitis, nephropathy and allergic reactions.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Bioactivity Studies on Hedera helix L. (Ivy) Flower Pollen and Ivy Bee Pollen

et al. 2023

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Bee pollen, known as a ‘life-giving dust’, is a product of honeybees using flower pollen grains and combining them with their saliva secretions. Thus, flower pollen could be an indicator of the bee pollen botanical source. Identification of bee pollen sources is a highly crucial process for the evaluation of its health benefits, as chemical composition is directly related to its pharmacological activity. In this study, the chemical profiles, contents of phenolic marker compounds and pharmacological activities of Hedera helix L. (ivy) bee pollen samples from Türkiye and Slovenia, as well as ivy flower pollen grains, were compared. High-performance thin-layer chromatography (HPTLC) analyses revealed that pollen samples, regardless of where they were collected, have similar chemical profiles due to the fact that they have the same botanical origins. Marker compounds afzelin, platanoside and quercetin-3-O-β-glucopyranosyl-(1→2)-β-galactopyranoside, common to both bee pollen and flower pollen, were isolated from bee pollen, and their structures were elucidated by nuclear magnetic resonance (NMR) and mass spectrometry (MS). These three compounds, as well as chlorogenic acid and 3,5-dicaffeoylquinic acid (found in flower pollen), were quantified using high-performance liquid chromatography (HPLC) analyses. In vitro tests and effect-directed analyses were used to evaluate the xanthine oxidase inhibition and antioxidant activity of the marker compounds and extracts from flower pollen and bee pollen. This is the first report comparing chemical profiles and related bioactivities of the flower pollen and bee pollen of the same botanical origin, as well as the first report of the chemical profile and related bioactivities of ivy flower pollen.

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Protective effects of Ligustrum robustum (Rxob.) Blume on oil oxidation during the high temperature processing

Liang,

Xiao,

Gao

et al. 2024

Food Measure

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Crosstalk between xanthine oxidase (XO) inhibiting and cancer chemotherapeutic properties of comestible flavonoids- a comprehensive update

Cited by 8 publications

References 517 publications

Preparation, Purification, and Identification of Novel Feather Keratin-Derived Peptides with Antioxidative and Xanthine Oxidase Inhibitory Activities

Preparation, Purification, and Identification of Novel Feather Keratin-Derived Peptides with Antioxidative and Xanthine Oxidase Inhibitory Activities

Phytochemical and Bioactivity Studies on Hedera helix L. (Ivy) Flower Pollen and Ivy Bee Pollen

Protective effects of Ligustrum robustum (Rxob.) Blume on oil oxidation during the high temperature processing

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