Crosstalk relationship between adiponectin receptors, PPAR-γ and α-adrenoceptors in renal vasculature of diabetic WKYs

Afzal, Samina; Sattar, M. A.; Eseyin, Olorunfemi A.; Attiq, Ali; Johns, Edward J.

doi:10.1016/j.ejphar.2021.174703

Cited by 2 publications

(1 citation statement)

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“…Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily ( Afzal et al, 2020 ). These ligand-activated transcription factors bind with the promoter region of the targeted gene at PPAR specific sequence of response elements ( Afzal et al, 2021 ; Afzal et al, 2022 ). Other than metabolism, PPAR has a putative role in cell differentiation and apoptosis via mediating the activities of transcriptional factors, including NF-κB.…”

Section: Signalling Cross-talks In Tumour Microenvironmentmentioning

confidence: 99%

Trinity of inflammation, innate immune cells and cross-talk of signalling pathways in tumour microenvironment

Attiq,

Afzal

2023

Front. Pharmacol.

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Unresolved inflammation is a pathological consequence of persistent inflammatory stimulus and perturbation in regulatory mechanisms. It increases the risk of tumour development and orchestrates all stages of tumorigenesis in selected organs. In certain cancers, inflammatory processes create the appropriate conditions for neoplastic transformation. While in other types, oncogenic changes pave the way for an inflammatory microenvironment that leads to tumour development. Of interest, hallmarks of tumour-promoting and cancer-associated inflammation are striking similar, sharing a complex network of stromal (fibroblasts and vascular cells) and inflammatory immune cells that collectively form the tumour microenvironment (TME). The cross-talks of signalling pathways initially developed to support homeostasis, change their role, and promote atypical proliferation, survival, angiogenesis, and subversion of adaptive immunity in TME. These transcriptional and regulatory pathways invariably contribute to cancer-promoting inflammation in chronic inflammatory disorders and foster “smouldering” inflammation in the microenvironment of various tumour types. Besides identifying common target sites of numerous cancer types, signalling programs and their cross-talks governing immune cells’ plasticity and functional diversity can be used to develop new fate-mapping and lineage-tracing mechanisms. Here, we review the vital molecular mechanisms and pathways that establish the connection between inflammation and tumour development, progression, and metastasis. We also discussed the cross-talks between signalling pathways and devised strategies focusing on these interaction mechanisms to harness synthetic lethal drug combinations for targeted cancer therapy.

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Section: Signalling Cross-talks In Tumour Microenvironmentmentioning

confidence: 99%