Crosstalks Between Gut Microbiota and Vibrio Cholerae

Qin, Zixin; Yang, Xiaoman; Chen, Guozhong; Park, Chaiwoo; Li, Zhi

doi:10.3389/fcimb.2020.582554

Cited by 26 publications

(20 citation statements)

References 104 publications

(110 reference statements)

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“…These findings have proved that transmission of ARGs across different taxonomic levels like bacterial families, genera and species occur and which are brought about by HGT and the same mechanisms affect the AMR evolution of VC (142). HGT occurs when presence of signals like stress (115), scarcity of nutrients (114), necessity for chromosomal repair (114), presence of antibiotics (96) stimulate the need for acquisition of genes that will help in adaptation and survival (115,192). Exchange of genes, occurs within exchange communities within the microbiome (187) which provides the optimum milieu for genetic exchange by providing the optimum ambience and parameters required to induce HGT like niche competition, stress and adaptation (192).…”

Section: Discussionmentioning

confidence: 96%

“…HGT occurs when presence of signals like stress (115), scarcity of nutrients (114), necessity for chromosomal repair (114), presence of antibiotics (96) stimulate the need for acquisition of genes that will help in adaptation and survival (115,192). Exchange of genes, occurs within exchange communities within the microbiome (187) which provides the optimum milieu for genetic exchange by providing the optimum ambience and parameters required to induce HGT like niche competition, stress and adaptation (192). However, there are also several barriers to HGT and therefore, often, introduction of exogenous DNA into VC is a challenging affair (129).…”

Section: Discussionmentioning

confidence: 99%

“…become dominant (191). The organisms with which VC coexists during diarrhea, may exert influence on VC w.r.t various aspects like niche competition, colonization resistance mechanisms, such as antimicrobial peptide production, nutrient competition, and intestinal barrier maintenance while VC senses those signals and modulates the expression of relevant genes to circumvent those stresses during infection, leading to successful colonization on the surface of small intestinal epithelial cells by employment of T6SS, QS, reactive oxygen species (ROS)/pH stress and bioactive metabolites (192). It is also in this milieu that optimal exchange of ARGs can occur (46) as exchange of ARGs is stress induced (96,115,119).…”

Section: The Role Of the Microbiome In The Evolution Of The Acquired Resistome Of V Choleraementioning

confidence: 99%

See 2 more Smart Citations

Mobile Genetic Elements of Vibrio cholerae and the Evolution of Its Antimicrobial Resistance

2021

Front. Trop. Dis

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Vibrio cholerae (VC) is the causative agent of the severe dehydrating diarrheal disease cholera. The primary treatment for cholera is oral rehydration therapy (ORT). However, in case of moderate to severe dehydration, antibiotics are administered to reduce morbidity. Due to the emergence of multidrug resistant (MDR) strains of VC routinely used antibiotics fail to be effective in cholera patients. Antimicrobial resistance (AMR) is encoded in the genome of bacteria and is usually acquired from other organisms cohabiting in the environment or in the gut with which it interacts in the gut or environmental niche. The antimicrobial resistance genes (ARGs) are usually borne on mobile genetic elements (MGEs) like plasmids, transposons, integrons and SXT constin. Horizontal gene transfer (HGT) helps in the exchange of ARGs among bacteria leading to dissemination of AMR. In VC the acquisition and loss of AMR to many antibiotics have been found to be a dynamic process. This review describes the different AMR determinants and mechanisms of resistance that have been discovered in VC. These ARGs borne usually on MGEs have been recovered from isolates associated with past and present epidemics worldwide. These are responsible for resistance of VC to common antibiotics and are periodically lost and gained contributing to its genetic evolution. These resistance markers can be routinely used for AMR surveillance in VC. The review also presents a precise perspective on the importance of the gut microbiome in the emergence of MDR VC and concludes that the gut microbiome is a potential source of molecular markers and networks which can be manipulated for the interception of AMR in the future.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: The Role Of the Microbiome In The Evolution Of The Acquired Resistome Of V Choleraementioning

confidence: 99%

See 1 more Smart Citation

Mobile Genetic Elements of Vibrio cholerae and the Evolution of Its Antimicrobial Resistance

2021

Front. Trop. Dis

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“…Given that the intestinal tract absorbs approximately 95% of nutrients, excretes approximately 80% of toxins, and regulates approximately 70% of immunity, it is clear that the intestinal tract is a critical organ involved in digestion, metabolism, and immunity (42). Indeed, the gastrointestinal system hosts the largest microecological niche in the human body, and its health thus determines the health of the entire organism (43). The pathogenesis of SARS-CoV-2 infection strongly resembles that of immune-mediated diseases, which has led to the hypothesis that targeted therapies used for the treatment of immune-mediated diseases may be effective for the treatment or prevention of COVID-19-related complications.…”

Section: Intestinal Microecology In Patients With Covid-19mentioning

confidence: 99%

Considerations and perspectives on digestive diseases during the COVID-19 pandemic: a narrative review

Li¹,

Li²,

Wang³

et al. 2021

Ann Palliat Med

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Coronavirus disease 2019 (COVID-19) was initially reported in December 2019, and since then it has become a pandemic with newly confirmed cases and deaths increasing continuously. The COVID-19 pandemic has dramatically impacted the organization and execution of activities in the clinical sector.Asymptomatic infections are increasingly being identified when patients seek medical advice for nonrespiratory system illnesses, particularly digestive system symptoms. This has posed a significant challenge for clinical diagnosis and treatment. Based on the clinical symptoms of patients with COVID-19 reported to date, patients with typical clinical symptoms of COVID-19 may also present with symptoms associated with the digestive system. Digestive illness symptoms in patients with COVID-19 are underscored by a bidirectional relationship between respiratory and digestive systems. Because the clinical diagnosis and treatment of digestive illnesses caused by COVID-19 have been challenging so far, we hypothesized that investigating the pathogenesis of digestive system diseases in patients with COVID-19 will provide potential novel targets for its prevention and treatment, and concurrently reduce COVID-19 virulence and sociosanitary burden. This review summarizes the relationship between the digestive and respiratory systems in patients with COVID-19 from the perspective of the "gut-lung" axis. We discuss extant literature on the pathogenesis of COVID-19-related digestive symptoms, which may facilitate differential diagnosis and treatment of this condition.

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“…Diseases or even death of aquatic animals caused by Vibrio infection have been reported worldwide and are showing an increasing trend [7,11,18,67]. Therefore, Vibriosis has caused significant impacts on human health and the development of aquaculture [68][69][70]. The pathogenicity of Vibrio is determined by multiple virulence factors encoded by its virulence genes [71][72][73][74].…”

Section: Pathogenicity Of Vibriomentioning

confidence: 99%

Community Change and Pathogenicity ofVibrio

Huang¹,

Gao²,

Zhang³

et al. 2021

Infections and Sepsis Development

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Vibrio is a rod-shaped Gram-negative bacteria, which is widely distributed in marine and estuarine environments worldwide. It is an important component of the aquatic ecosystem and plays an important role in biogeochemical cycle. Its population dynamics are usually affected by climate and seasonal factors. Most of the Vibrios in the environment are not pathogenic, but some of them are pathogenic bacteria for human and animal, such as Vibrio cholerae, Vibrio vulnificus, Vibrio parahaemolyticus, and Vibrio anguillarum, etc., which are generally reported to be related to aquatic animal diseases and human food-borne diseases. Over the last couple of years, due to the influence of the rising seawater temperature and climate change, the incidence of diseases caused by Vibrio infection has increased significantly, which poses a great threat to human health and aquaculture. The research on pathogenic Vibrio has attracted more and more attention. The abundance and community changes of Vibrio in the environment are usually controlled by many biological and abiotic factors. The Vibrio pathogenicity is related to the virulence factors encoded by virulence genes. The process of Vibrio infecting the host and causing host disease is determined by multiple virulence factors acting together, instead of being determined by a single virulence factor. In this chapter, community changes of Vibrio, as well as the virulence factors of Vibrio and the related virulence genes of Vibiro are summarized, and their important roles in Vibrio infection are also discussed.

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Crosstalks Between Gut Microbiota and Vibrio Cholerae

Cited by 26 publications

References 104 publications

Mobile Genetic Elements of Vibrio cholerae and the Evolution of Its Antimicrobial Resistance

Mobile Genetic Elements of Vibrio cholerae and the Evolution of Its Antimicrobial Resistance

Considerations and perspectives on digestive diseases during the COVID-19 pandemic: a narrative review

Community Change and Pathogenicity ofVibrio

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