Crosstolerance between butorphanol and morphine in rats

Feng, Yang Zheng; Narita, Minoru; Tseng, Yi‐Tang; Hoskins, Beth; Ho, Ing K.

doi:10.1016/0091-3057(94)90084-1

Cited by 12 publications

(3 citation statements)

References 22 publications

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“…Extending an earlier report (Feng et al 1994), butorphanol conferred tolerance to the effects of U50,488 in all groups of rats, although the magnitude of these effects was not a function of the butorphanol maintenance dose. Previous studies have concluded that the rate-decreasing effects of U50,488 are mediated by its activity at the kappa opioid receptor, because these effects are antagonized by the kappa-selective antagonist norbinaltorphimine but not by the mu-selective antagonist beta-funaltrexamine (Pitts et al 1996a).…”

Section: Discussionsupporting

confidence: 52%

Tolerance and cross-tolerance to the rate-suppressing effects of opioids in butorphanol-treated rats: influence of maintenance dose and relative efficacy at the mu receptor

Smith

Picker

1998

Psychopharmacology

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The purpose of the present investigation was to examine the development of tolerance to the rate-suppressing effects of mu and kappa opioids in rats administered either 3.0 (low) or 30 (high) mg/kg per day of butorphanol, an opioid with low relative efficacy at the mu receptor. The mu opioids butorphanol, buprenorphine, morphine, fentanyl and sufentanil, and the kappa opioid U50,488 dose-dependently suppressed responding under all conditions examined. In rats administered the low maintenance dose of butorphanol, tolerance developed to the effects of butorphanol, buprenorphine and morphine, but not to fentanyl and sufentanil. In rats administered the high maintenance dose, tolerance developed to all of the mu opioids examined. In both treatment groups, the degree to which tolerance developed was greater for butorphanol and buprenorphine than for morphine, fentanyl and sufentanil; and the degree to which tolerance developed to these mu opioids was greater in rats administered the high maintenance dose of butorphanol. The tolerance that developed to morphine, fentanyl and sufentanil was not altered when tested at both 23 and 47 h following the previous maintenance dose of butorphanol, suggesting that these changes were not due to any acute pharmacological interactions between butorphanol and the test compound (i.e., antagonism). Tolerance was also conferred to the kappa opioid U50,488 in both groups of rats, and in rats administered the high maintenance dose, this effect was obtained when tested 23 and 47 h following the previous maintenance dose of butorphanol. Physical dependence developed in rats administered the high maintenance dose of butorphanol, as evidenced by the development of enhanced sensitivity to the rate-suppressing effects of naloxone, and the finding that 30 mg/kg naloxone decreased body weight in a time-dependent manner. No physical dependence was apparent in rats administered the low maintenance dose of butorphanol. These data suggest that during chronic treatment with butorphanol, (1) greater degrees of tolerance are conferred to drugs possessing low efficacy at the mu opioid receptor, (2) tolerance is enhanced as the maintenance dose of the toleragen is increased, and (3) mu-opioid tolerance may be observed under conditions that do not produce mu-opioid dependence.

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Section: Discussionsupporting

confidence: 52%

Tolerance and cross-tolerance to the rate-suppressing effects of opioids in butorphanol-treated rats: influence of maintenance dose and relative efficacy at the mu receptor

Smith

Picker

1998

Psychopharmacology

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“…In previous studies [12,13], tolerance to butorphanol seemed to be dosedependent, with tolerance developing with higher doses.…”

Section: Discussionmentioning

confidence: 93%

Tolerance to the analgesic effect of buprenorphine, butorphanol, nalbuphine, and cyclorphan, and cross-tolerance to morphine

Gringauz

Rabinowitz

Stav

et al. 2001

Journal of Anesthesia

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“…In rhesus monkeys treated once a day with a low to intermediate dose of morphine, butorphanol does not substitute for naltrexone indicating that in less dependent or tolerant monkeys, butorphanol does not precipitate a withdrawal-like cue (France and Woods, 1989). Tolerance and cross-tolerance to the antinociceptive and hyperthermic effects of μ opioid agonists morphine, fentanyl, butorphanol and buprenorphine, and κ agonist U50,488 was observed after high but not low treatment doses of butorphanol in rats (Bhargava, 1994;Feng et al, 1994a;Feng et al, 1994b;Smith and Picker, 1998). Also, chronic treatment with butorphanol conferred greater tolerance to lower efficacy μ agonists buprenorphine and butorphanol than higher efficacy μ agonists morphine and fentanyl (Smith and Picker, 1998).…”

Section: Tolerance and Physical Dependence To Butorphanol Or The Precmentioning

confidence: 99%

EVALUATION OF CARDIORESPIRATORY, BLOOD GAS, AND LACTATE VALUES DURING EXTENDED IMMOBILIZATION OF WHITE RHINOCEROS (CERATOTHERIUM SIMUM)

Buss¹,

Olea‐Popelka²,

Meyer³

et al. 2015

Journal of Zoo and Wildlife Medicine

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Crosstolerance between butorphanol and morphine in rats

Cited by 12 publications

References 22 publications

Tolerance and cross-tolerance to the rate-suppressing effects of opioids in butorphanol-treated rats: influence of maintenance dose and relative efficacy at the mu receptor

Tolerance and cross-tolerance to the rate-suppressing effects of opioids in butorphanol-treated rats: influence of maintenance dose and relative efficacy at the mu receptor

Tolerance to the analgesic effect of buprenorphine, butorphanol, nalbuphine, and cyclorphan, and cross-tolerance to morphine

EVALUATION OF CARDIORESPIRATORY, BLOOD GAS, AND LACTATE VALUES DURING EXTENDED IMMOBILIZATION OF WHITE RHINOCEROS (CERATOTHERIUM SIMUM)

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