“…The nonpolar fraction and its subfractions of S. Grantus and E. umbellate stem exhibited a cytostatic effect on human tumor cell lines (glioma, breast, kidney, and lung), inhibited by 0.37 to 2.9 μg/mL, with the compound 3,4,12,13-tetraacetylphorbol-20-phenylacetate with antiproliferative activity against glioma (25.2 μg/mL), kidney (24.1 μg/mL), lung (31.1 μg/mL) and leukemia (65.3 μg/mL) cell lines (Campos et al, 2016). Croton macrobothrys Baill is a tree from southern Brazil popularly known as "dragon's blood" (Caruzo et al, 2019). The n-hexane, dichloromethane, and methanol extracts of the leaf have in vitro antiproliferative activity against kidney (786-0), colon (HT-29) leukemia (K562), ovarian (NCI-ADR/RES), lung (NCI-H460), mammary (MCF-7), prostate (PC-3), ovarian (OVCAR-3), glioma (U251) and melanoma (UACC-62) cell lines.…”