Croton membranaceus Improves Some Biomarkers of Cardiovascular Disease and Diabetes in Genetic Animal Models

Asare, George Awuku; Adjei, Samuel; Afriyie, Daniel Kwame; Appiah-Danquah, Akua Bempomaa; Asia, Jonas; Asiedu, Bernice; Santa, Sheila; Doku, Derek

doi:10.7860/jcdr/2015/14844.6899

Cited by 3 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the aqueous extract of the roots also improved the cardiovascular profile by significantly diminishing low-density lipoprotein cholesterol and C-reactive protein and increasing high-density lipoprotein cholesterol in spontaneously hypertensive rats at a dose of 100 mg/kg/day for 60 days. In addition, blood glucose levels of db / db mice were significantly reduced after 3 h of the administration of the extract at a dose of 250 mg/kg [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Diabetes-Related Mechanisms of Action Involved in the Therapeutic Effect of Croton Species: A Systematic Review

Espinoza-Hernández

Moreno-Vargas

Andrade‐Cetto

2023

Plants

View full text Add to dashboard Cite

Over the years, ethnopharmacological and phytochemical investigations have been conducted to understand the potential effects of the Croton genus on several diseases. It has been revealed that these terpenoid-rich species traditionally used to treat gastrointestinal diseases, heal wounds, and relieve pain have a wide range of therapeutic effects; however, those used to treat diabetes, as well as their action mechanisms, have not been reviewed so far. Therefore, the main objective of this review was to compile all Croton species that have shown pharmacological effects against diabetes and describe their action mechanisms. Through a search of the literature, 17 species with hypoglycemic, antihyperglycemic, antilipidemic, antihypertensive, antioxidant, and anti-inflammatory effects were found. Among the mechanisms by which they exerted these effects were the inhibition of α-glucosidases, the promotion of insulin secretion, and the increase in glucose uptake. Interestingly, it was found that some of them may have antihyperglycemic properties, although there were no ethnopharmacological reports that support their traditional use. Moreover, others only presented studies on their hypoglycemic effect in fasting, so further works are encouraged to describe the mechanisms involved in lowering fasting blood glucose levels, such as hepatic glucose production, especially for C. cajucara, C. cuneatus, C. gratissimus var. gratissimus, C. guatemalensis, and C. membranaceus. It is expected that this review contributes to the plant science knowledge of the genus, and it can be used in future references on the identification and development of new molecules/phytomedicines that help in the treatment of diabetes.

show abstract

Section: Resultsmentioning

confidence: 99%

Diabetes-Related Mechanisms of Action Involved in the Therapeutic Effect of Croton Species: A Systematic Review

Espinoza-Hernández

Moreno-Vargas

Andrade‐Cetto

2023

Plants

View full text Add to dashboard Cite

show abstract

“…Also, the aqueous root extract is used to treat measles (Schmelzer and Gurib-Fakim 2008), while it is non-toxic yet exhibits cardio-protective, anti-atherogenic, and anti-ischemic potentials (Afriyie et al 2013). Furthermore, the ethanolic and aqueous root extracts have improve glycemic index in diabetic patients and reduce glucose levels (Afriyie et al 2013;Sarkodie et al 2014;Asare et al 2015a); it demonstrates their potential to treat type I diabetes (diabetes mellitus), which justifies the use of leaf extract by Ghana traditional healers (Afriyie et al 2013;Sarkodie et al 2014;Asare et al 2015a). The leaf and root extracts are used to aromatize tobacco in the Bahamas and improve digestion in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

“…The methanolic root extracts contain cajucarinolide to induce apoptosis (programmed cell death) in cancer cells (Block et al 2005), and recent findings by Bayor et al (2009) revealed antimicrobial activity, antihyperglycaemic properties, and cytotoxic effects against human prostate cells. The ethanolic and aqueous root extracts contain a compound, N [N-(2-methylbutanoyl) gluta minoyl]-2-phenylethya mine, to improve glycemic index in diabetic (type I diabetes, i.e, diabetes mellitus) and reduce glucose levels (Afriyie et al 2013;Sarkodie et al 2014;Asare et al 2015a). Despite its rich phytochemicals, the plant still grows without propagating commercially in the wild.…”

Section: Introductionmentioning

confidence: 99%

Effective decontamination and multiplication of Croton membranaceus in vitro

2022

View full text Add to dashboard Cite

Abstract. Adukonu IA, Ayeh KO, Acheampong E. 2022. Effective decontamination and multiplication of Croton membranaceus in vitro. Cell Biol Dev 6: 68-81. Croton membranaceus Müll. Arg. is a useful herb with medicinal properties, and its leaves, roots, and bark are used to treat diverse ailments. However, the harvesting method by traditional medical practitioners without replacement exposes it to extinction. Therefore, the only means of propagating is by relatively slow use of seeds, and an alternative propagation method is needed for field establishment and nursery. Therefore, this study aims at determining an effective propagation by sterilization regime and subsequent in vitro regeneration using different explants; intact seeds, isolated embryos, coatless seeds, and nodal-cutting. The explants were decontaminated using double sterilization; the best was achieved by pre-treatment with 70% ethanol for 3 min before immersion in sodium hypochlorite (NaOCl). Intact seeds were effectively decontaminated by immersion in 15% NaOCl solution for 20 min, then by 10% NaOCl for 15 min. Conversely, coatless seeds were effectively decontaminated when isolated from intact seeds immersed in 20% NaOCl solution for 20 min and 15% NaOCl for 15 min. Further, embryos isolated from intact seeds were effectively decontaminated in 20% NaOCl for 15 min, then by 15% NaOCl for 10 min sequentially. These sterilization regimes successfully decontaminated 86% intact seeds, 100% isolated embryos, and 80% coatless seeds. Nodal-cutting explants were best decontaminated by immersion in 20% NaOCl solution for 15 min, followed by 15% NaOCl for 10 min sequentially without ethanol pre-treatment. This sterilization regime successfully decontaminated 100% of the nodal-cutting explants. However, the development of shoot explants varied in response to sterilization. Intact seeds did not develop into shoots, while isolated embryos, coatless seeds, and nodal-cutting explants developed into shoots independent of the sterilization regime. Shoot development was highest with the medium’s shoot-tip explants added with BAP, NAA, and GA3. Shoot multiplication was best achieved on an MS basal medium with 5.0 ?M BAP, 0.5 ?M NAA, and 5.0 ?M GA3 amendment.

show abstract

“…Recent pharmacological and toxicological studies on the aqueous root extract of C. membranaceus revealed its safety in both acute and subchronic toxicity studies. Furthermore, C. membranaceus possesses antimicrobial, anticancer, anti-diabetic, anti-antherogenic, and anti-ischaemic potentials as well as prostate organ targeting activity 15,16 . A study on the ethanolic root extract of C. membranaceus revealed its antioxidant properties 17 , however, there is no related studies on the stem extracts.…”

mentioning

confidence: 99%

Untitled

2022

IJPSR

View full text Add to dashboard Cite

Croton membranaceus is a tropical plant that grows wildly in some West African countries. Though several parts of this plant are used for the treatment of diverse disease conditions, its root extracts are traditionally used mainly in Ghana for the management of prostate diseases. This present study aimed to investigate the in-vitro and in-vivo antioxidant activities of the stem extracts of C. membranaceus and assess their total phenolic and flavonoid contents. DPPH free radical scavenging method was employed in the preliminary screening for antioxidant activities of the direct aqueous (CMASE) and sequential fractions (SECM) of the pulverized stem of C. membranceus: hexane, ethanol, ethyl acetate, and aqueous. In-vivo antioxidant effects of CMASE on liver antioxidant enzymes/markers [Glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA)] in Sprague-Dawley (S-D) rats after 90 days were also investigated. In-vitro investigations revealed that all SECM and CMASE had some antioxidant activities. Ethanolic and ethyl acetate fractions exhibited the highest antioxidant activities with EC 50 values of 0.35 and 1.41 mg/ml. Phenols were present in the SECM and CMASE. Flavonoids were present in all the fractions except the CMASE and sequential aqueous fraction. CMASE induced non-significant dosedependent elevations of mean liver SOD, GSH, and CAT levels but marginal decline in MDA levels in the treated rat groups. SECM and CMASE possess mild antioxidant activities in-vitro and in-vivo, contributing to mitigating oxidative stress-related diseases such as benign prostatic disease. INTRODUCTION:Oxidative stress is a condition in which there is an imbalance in the rate of release or production of free radicals in the body compared to its detoxification, hence resulting in oxidative tissue damage 1 .

show abstract

Croton membranaceus Improves Some Biomarkers of Cardiovascular Disease and Diabetes in Genetic Animal Models

Cited by 3 publications

References 20 publications

Diabetes-Related Mechanisms of Action Involved in the Therapeutic Effect of Croton Species: A Systematic Review

Diabetes-Related Mechanisms of Action Involved in the Therapeutic Effect of Croton Species: A Systematic Review

Effective decontamination and multiplication of Croton membranaceus in vitro

Untitled

Contact Info

Product

Resources

About