Croton oil-induced hemorrhoid model in rat. Comparison of anti-inflammatory activity of diflucortolone valerate with other glucocorticoids.

Some pharmacological actions of Myrica rubra part 1: Effect on experimentally-induced gastric ulcers, inflammation and haemorrhoids in rats

“…The results of this study revealed another inherent property for M. rubra drink (Yumberry), an antiinflammatory and antihaemorroidal action as shown by the inhibition of carrageenan-induced paw oedema (Winter et al, 1962) and croton oil mixture-induced inflammatory haemorrhoids (Nishiki et al, 1988;Okumura et al, 1995). Carrageenan-induced inflammation is shown to be due to release of various mediators, majorities of which are TNFα (Gong et al, 2009;Bhavin et al, 2010), IL-1β (Chou, 2003;Loram et al, 2007), nitrogen oxide (NO) (Bilici et al, 2002), prostaglandins, kinins, histamine and serotonin (Bhukya et al, 2009).…”

“…Hemorrhoids were induced in both control and treated animals by a modification of the methods described by Nishiki et al (1988) and Okumura et al (1995). In brief, male Wistar rats (body weight 250 ± 10 g) were used in this study.…”

Multi-model confirmatory evaluation of anti-inflammatory, analgesic and antioxidant activities of Putranjiva roxburghii wall

“…Croton oil-induced anus edema model involves infiltration of inflammatory cells, vasodilation, and destruction of the mucosal epithelium 35 . P.roxburghii 500mg/kg decreased anus swelling but needed a higher dose (>500 mg/kg) than those of other systemic models, as this model may produce very large amounts of inflammatory tissue.…”

The inhibitory effects of α2‐adrenoceptor agonists on gastrointestinal transit during croton oil‐induced intestinal inflammation

“…(Stewart et at., 1975a;Gaginella et at., 1975). However, CO is an irritant that produces inflammation in different tissues, specially skin and mucosae (Nishiki et al, 1988;Colorado et al, 1991) and induces diarrhoea associated with intestinal inflammation in mice (Pol et al, 1994; (Gray & Ferrell, 1992).…”