2013
DOI: 10.1590/s1984-82502013000400027
|View full text |Cite
|
Sign up to set email alerts
|

Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit

Abstract: Croton schiedeanus Schltd (N.V.: "almizclillo") is a plant used in traditional medicine as an antihypertensive in Colombia. It contains flavonoid, diterpenoid and fenilbutanoid metabolites that have vasodilatation effects linked to the NO/cGMP pathway. This work aimed to assess the capacity of a 96% EtOH extract to prevent the hypertension induced by nitric oxide (NO) deficiency in rats. The NO synthase inhibitor L-NAME (10 mg/kg/d, i.p) was administered during five weeks to three groups of rats (6-7 animals):… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
5
0

Year Published

2016
2016
2022
2022

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 6 publications
(5 citation statements)
references
References 28 publications
0
5
0
Order By: Relevance
“…Lee et al . [ 37 ] reported a prolongation of QT interval with hypoglycemia, and this was associated with increased risk of ventricular arrhythmias. Increased free radical (superoxide anion) activity can potentially elevate blood pressure by inactivating NO and consequently increase systemic vascular resistance [ 38 ].…”
Section: Discussionmentioning
confidence: 99%
“…Lee et al . [ 37 ] reported a prolongation of QT interval with hypoglycemia, and this was associated with increased risk of ventricular arrhythmias. Increased free radical (superoxide anion) activity can potentially elevate blood pressure by inactivating NO and consequently increase systemic vascular resistance [ 38 ].…”
Section: Discussionmentioning
confidence: 99%
“…The descending thoracic aorta was dissected and placed in a petri dish containing an oxygenated Krebs solution with the following composition (mM): NaCl 118.7; KCl 4.7; CaCl 2 2.5; NaHC0 3 25.0; MgS0 4 .7H 2 0 1.2; glucose 11.0 and ascorbic acid 0.1. thoracic aorta rings (3-4 mm in length) were carefully excised and submerged in Allhin organ chambers containing 10 mL of Krebs solution bathing medium maintained at 37ºC, pH: 7.38 -7.42 and continuously gassed with a carbogen mixture of 95% O 2 and 5% CO 2 . About 8-10 rings were obtained from each aorta (33).…”
Section: Aortic Ring Preparationmentioning
confidence: 99%
“…This information becomes of great relevance for both the academic community and the scientific community, as a way of designing new intervention strategies, so that the individual with this disease can achieve greater success in its control and treatment. Thus, pharmacological and nonpharmacological measures protect against endothelial dysfunction by helping to preserve cardiovascular function through the reduction of oxidative stress and other mechanisms [ 9 ]. Figure 1 summarizes some physiological mechanisms towards therapeutic approaches that can be addressed.…”
Section: Introductionmentioning
confidence: 99%