Croton zambesicus Root Extract Exert Laxative Effect in Rats

Abstract

Background: Croton zambesicus Muell Arg. (Euphorbiaceace) is a medicinal plant used traditionally in the treatment of some ailments.
 Aim: The root extract of Croton zambesicus was evaluated for effect on the gastrointestinal tract (GIT).
 Materials and Methods: The root extract of C. zambesicus (27-81 mg/kg) was investigated for laxative effect in rats using different experimental models to study its effect on the GIT.
 Results: The extract was found to significantly increase the frequency and output of faecal matters in rats in all the experimental models studied.
 Conclusion: The findings of this study show that the root extract of C. zambesicus has a significant laxative effect and this supports its use in ethnomedicine for the treatment of gastrointestinal tract disorders.

Evaluation of Inhibitory Activities of Two Common Vegetables (Heinsia crinata and Lasianthera africana) on Alpha Amylase and Alpha Glucosidase of Rats

“…These others (Okokon et al, 2009a;Okokon et al, 2009b). Reports of their biological activities as antimalarial (Okokon et al, 2007;Okokon et al,2009b) antimicrobial (Andy et al, 2008;Morah and Ashipu, 2017), antiulcer (Okokon et al, 2009a;Okokon et al, 2010), anticonvulsant (Okokon et al, 2021), antidiabetic and hypoglycaemic (Okokon et al, 2009b;Ebong et al, 2014;Ekandem et al, 2016;Inyang et al, 2016), analgesic and antipyretic (Andrew et al, 2012;Okokon et al, 2013a), immunomodulatory (Okokon et al, 2013b) are published in literatures. Two triterpenoid saponins have been isolated from the leaves of H. crinata (Babady-Billa et al, 1994) and two…”