Crotoxin modulates inflammation and macrophages’ functions in a murine sepsis model

Bretones, Marisa Langeani; Sampaio, Sandra Coccuzzo; Barbeiro, Denise Frediani; Ariga, Suely Kubo; Soriano, Francisco; Lima, Thaís Martins de

doi:10.1016/j.toxicon.2022.07.007

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…In the bone-marrow-derived macrophage of mice with sepsis, CTX could improve the inflammatory response caused by sepsis and reduce the mortality of CLP mice by regulating phagocytosis and promoting the secretion of ROS and NO. Moreover, it reduced the mortality rates of CLP mice by 40% [52]. Coenzyme Q10 significantly increases the level of Beclin1, decreases the levels of live injury indices (alanine aminotransferase, alkaline phosphatase, and aspartate aminotrans ferase) and inflammatory mediators (IL-6, IL-1 β, TNF-α, and NLRP3) in CLP mice, and reduces liver inflammation and injury [49].…”

Section: Regulators Of Inflammationmentioning

confidence: 98%

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Research Progress of Macromolecules in the Prevention and Treatment of Sepsis

Su,

Wu,

Zhou

et al. 2023

IJMS

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Sepsis is associated with high rates of mortality in the intensive care unit and accompanied by systemic inflammatory reactions, secondary infections, and multiple organ failure. Biological macromolecules are drugs produced using modern biotechnology to prevent or treat diseases. Indeed, antithrombin, antimicrobial peptides, interleukins, antibodies, nucleic acids, and lentinan have been used to prevent and treat sepsis. In vitro, biological macromolecules can significantly ameliorate the inflammatory response, apoptosis, and multiple organ failure caused by sepsis. Several biological macromolecules have entered clinical trials. This review summarizes the sources, efficacy, mechanism of action, and research progress of macromolecular drugs used in the prevention and treatment of sepsis.

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Section: Regulators Of Inflammationmentioning

confidence: 98%

Section: Proteins and Peptidesmentioning

confidence: 99%

Research Progress of Macromolecules in the Prevention and Treatment of Sepsis

Su,

Wu,

Zhou

et al. 2023

IJMS

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Cytotoxic effect of crotoxin on cancer cells and its antitumoral effects correlated to tumor microenvironment: A review

Almeida

Silva

Oliveira

et al. 2023

International Journal of Biological Macromolecules

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Biological and Medical Aspects Related to South American Rattlesnake Crotalus durissus (Linnaeus, 1758): A View from Colombia

Cañas

2022

Toxins

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In Colombia, South America, there is a subspecies of the South American rattlesnake Crotalus durissus, C. d. cumanensis, a snake of the Viperidae family, whose presence has been reduced due to the destruction of its habitat. It is an enigmatic snake from the group of pit vipers, venomous, with large articulated front fangs, special designs on its body, and a characteristic rattle on its tail. Unlike in Brazil, the occurrence of human envenomation by C. durisus in Colombia is very rare and contributes to less than 1% of envenomation caused by snakes. Its venom is a complex cocktail of proteins with different biological effects, which evolved with the purpose of paralyzing the prey, killing it, and starting its digestive process, as well as having defense functions. When its venom is injected into humans as the result of a bite, the victim presents with both local tissue damage and with systemic involvement, including a diverse degree of neurotoxic, myotoxic, nephrotoxic, and coagulopathic effects, among others. Its biological effects are being studied for use in human health, including the possible development of analgesic, muscle relaxant, anti-inflammatory, immunosuppressive, anti-infection, and antineoplastic drugs. Several groups of researchers in Brazil are very active in their contributions in this regard. In this work, a review is made of the most relevant biological and medical aspects related to the South American rattlesnake and of what may be of importance for a better understanding of the snake C. d. cumanensis, present in Colombia and Venezuela.

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Crotoxin modulates inflammation and macrophages’ functions in a murine sepsis model

Cited by 3 publications

References 29 publications

Research Progress of Macromolecules in the Prevention and Treatment of Sepsis

Research Progress of Macromolecules in the Prevention and Treatment of Sepsis

Cytotoxic effect of crotoxin on cancer cells and its antitumoral effects correlated to tumor microenvironment: A review

Biological and Medical Aspects Related to South American Rattlesnake Crotalus durissus (Linnaeus, 1758): A View from Colombia

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