Crotoxin suppresses the tumorigenic properties and enhances the antitumor activity of Iressa® (gefinitib) in human lung adenocarcinoma SPCA-1 cells

Wang, Junhua; Qin, Xiuguang; Zhang, Zhiqiang; Chen, Mei‐Ling; Wáng, Ying; Gao, Beile

doi:10.3892/mmr.2014.2620

Cited by 20 publications

(11 citation statements)

References 15 publications

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“…(2) the toxin has promising medicinal applications due to its anti-inflammatory, immunosuppressive, antitumor, and analgesic properties [84,[90][91][92]. The potential medicinal application of CTX, as demonstrated in phase I clinical trials against cancer [18,93], stresses the importance of analyzing the side effects of the toxin that may occur in possible cases of intoxication during its therapeutic use.…”

Section: Discussionmentioning

confidence: 99%

Crotoxin-Induced Mice Lung Impairment: Role of Nicotinic Acetylcholine Receptors and COX-Derived Prostanoids

et al. 2020

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Respiratory compromise in Crotalus durissus terrificus (C.d.t.) snakebite is an important pathological condition. Considering that crotoxin (CTX), a phospholipase A2 from C.d.t. venom, is the main component of the venom, the present work investigated the toxin effects on respiratory failure. Lung mechanics, morphology and soluble markers were evaluated from Swiss male mice, and mechanism determined using drugs/inhibitors of eicosanoids biosynthesis pathway and autonomic nervous system. Acute respiratory failure was observed, with an early phase (within 2 h) characterized by enhanced presence of eicosanoids, including prostaglandin E2, that accounted for the increased vascular permeability in the lung. The alterations of early phase were inhibited by indomethacin. The late phase (peaked 12 h) was marked by neutrophil infiltration, presence of pro-inflammatory cytokines/chemokines, and morphological alterations characterized by alveolar septal thickening and bronchoconstriction. In addition, lung mechanical function was impaired, with decreased lung compliance and inspiratory capacity. Hexamethonium, a nicotinic acetylcholine receptor antagonist, hampered late phase damages indicating that CTX-induced lung impairment could be associated with cholinergic transmission. The findings reported herein highlight the impact of CTX on respiratory compromise, and introduce the use of nicotinic blockers and prostanoids biosynthesis inhibitors as possible symptomatic therapy to Crotalus durissus terrificus snakebite.

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Section: Discussionmentioning

confidence: 99%

Crotoxin-Induced Mice Lung Impairment: Role of Nicotinic Acetylcholine Receptors and COX-Derived Prostanoids

et al. 2020

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“…CB is not only a corrector, but also acts as a potentiator of CFTR Cl -currents, fitting into a new class of modulators encompassing both correcting and potentiating activities 17 . The potentiating activity of CB was demonstrated in different cell models and in mouse colon tissue by electrophysiological assays (Fig.…”

Section: Discussionmentioning

confidence: 99%

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆ F508CFTR Dysfunction: Impact in Cystic Fibrosis

Faure

Bakouh

Lourdel

et al. 2016

Journal of Molecular Biology

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“…CTX is responsible for neurotoxicity and myotoxicity, both important events on pathophysiology (5,(58)(59)(60). Studies have also brought novel perspectives for CTX as a possible pharmacological strategy due to its anti-inflammatory/immunosuppressive, antitumoral, and microbicidal effects (61)(62)(63).…”

Section: Crotoxin (Ctx)mentioning

confidence: 99%

Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology

Pucca

Bernarde

Rocha³

et al. 2021

Front. Immunol.

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Crotalus durissus ruruima is a rattlesnake subspecies mainly found in Roraima, the northernmost state of Brazil. Envenomings caused by this subspecies lead to severe clinical manifestations (e.g. respiratory muscle paralysis, rhabdomyolysis, and acute renal failure) that can lead to the victim’s death. In this review, we comprehensively describe C. d. ruruima biology and the challenges this subspecies poses for human health, including morphology, distribution, epidemiology, venom cocktail, clinical envenoming, and the current and future specific treatment of envenomings by this snake. Moreover, this review presents maps of the distribution of the snake subspecies and evidence that this species is responsible for some of the most severe envenomings in the country and causes the highest lethality rates. Finally, we also discuss the efficacy of the Brazilian horse-derived antivenoms to treat C. d. ruruima envenomings in Roraima state.

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Crotoxin suppresses the tumorigenic properties and enhances the antitumor activity of Iressa® (gefinitib) in human lung adenocarcinoma SPCA-1 cells

Cited by 20 publications

References 15 publications

Crotoxin-Induced Mice Lung Impairment: Role of Nicotinic Acetylcholine Receptors and COX-Derived Prostanoids

Crotoxin-Induced Mice Lung Impairment: Role of Nicotinic Acetylcholine Receptors and COX-Derived Prostanoids

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆ F508CFTR Dysfunction: Impact in Cystic Fibrosis

Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology

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