CRP Correlates with Clinical Score in Ulcerative Colitis but Not in Crohn’s Disease

Rodgers, Alexander; Cummins, Adrian G.

doi:10.1007/s10620-006-9691-2

Cited by 65 publications

(39 citation statements)

References 17 publications

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“…C-reactive protein, sedimentation rate, white blood cell count, and platelet count are known markers of disease activation in IBD, but their correlation with disease activity is reported to be different in different studies (24)(25)(26)(27)(28)(29). In our study, there was a weak correlation in all UC cases in terms of CRP and TGF-ß1 levels, whereas no correlation was established between the other parameters and TGF-ß1.…”

Section: Discussionmentioning

confidence: 99%

Plasma transforming growth factor-ß1 level in inflammatory bowel disease

Kılıç

Ayaz²,

Özın³

et al. 2009

Turk J Gastroenterol

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Section: Discussionmentioning

confidence: 99%

Plasma transforming growth factor-ß1 level in inflammatory bowel disease

Kılıç

Ayaz²,

Özın³

et al. 2009

Turk J Gastroenterol

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“…C-reactive protein (CRP) can be a useful marker of inflammatory activity in the gut, but there are conflicting reports on the ability of CRP to predict disease activity, showing more correlation with Crohn's disease (CD) and less with ulcerative colitis (UC) [14].…”

Section: Introductionmentioning

confidence: 99%

Increased Folate Intake with No Changes in Serum Homocysteine and Decreased Levels of C-Reactive Protein in Patients with Inflammatory Bowel Diseases

et al. 2008

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In order to increase dietary folic acid intake and to improve nutritional status regarding folate by controlling homocysteine concentrations, ten patients with inflammatory bowel diseases (Crohn's disease in the colon and ulcerative colitis) received individualized nutritional guidance and were followed up as outpatients for 2 months. The following procedures were performed at the beginning of the study (T0), after 1 month (T1) and at the end of the study (T2): collection of anthropometric data (weight and height), dietary data (24 h diet recall), and blood under fasting condition for the determination of serum folic acid, homocysteine, C-reactive protein, and vitamin B12. Plasma folic acid deficiency was not detected but hyperhomocysteinemia was present in six individuals and C-reactive protein (CRP) was increased (>0.5 mg/dl) in seven patients. After the patients were instructed there was a significant increase in vitamin B6 intake (about 35%) and in folate intake (49.6%). Mean plasma levels of folic acid, homocysteine, and vitamin B12 did not change, but there was a significant decrease of CRP at T1, 0.36 mg dl(-1) on average (P = 0.01), which was maintained at T2. We conclude that the increased folate intake reported by this group of patients was not reflected in improved serum concentrations of folic acid and homocysteine. However, the guidelines for the patients probably induced them to choose a more adequate diet, providing nutrients that help control the inflammatory process.

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“…However, most of them are not adequate if used alone. For instance, CRP usually does not correlate well with the clinical score in CD (19). Physicians usually tend to rely on their global clinical judgment, which has great intra-and inter-observer variability (18).…”

Section: Discussionmentioning

confidence: 99%

Assessment of presence and grade of activity in ileal Crohn’s disease

Yüksel¹,

Ipek²,

Topal³

et al. 2014

Turk J Gastroenterol

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Background/Aims: To assess the sensitivity of magnetic resonance enterography (MRE) in the diagnosis of Crohn's disease (CD) activity and correlation between endoscopic and MRE scores in predicting the activity grade. Materials and Methods: Twenty-five ileal CD patients with clinical and biochemical evidence of activation underwent ileocolonoscopy and MRE within 7 days of their application. Simplified endoscopic scoring of CD (SES-CD) and MRE scores was done and compared with each other and other parameters of activation (CRP, leukocyte count, platelet count). Results: The sensitivity of MRE scoring was found to be 92%; however, the statistical correlation with SES-CD was not significant (p=0.83) for the grading of the activity. Conclusion: MRE scoring is sensitive enough to use in CD activity evaluation; however, it can not be used alone, and it is rather a complementary technique to endoscopy and is especially valuable for patients with extraluminal disease.

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CRP Correlates with Clinical Score in Ulcerative Colitis but Not in Crohn’s Disease

Cited by 65 publications

References 17 publications

Plasma transforming growth factor-ß1 level in inflammatory bowel disease

Plasma transforming growth factor-ß1 level in inflammatory bowel disease

Increased Folate Intake with No Changes in Serum Homocysteine and Decreased Levels of C-Reactive Protein in Patients with Inflammatory Bowel Diseases

Assessment of presence and grade of activity in ileal Crohn’s disease

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