CRP, TNFα, IL-1ra, IL-6, IL-8 and IL-10 in blood serum of colorectal cancer patients

Abstract

Blood serum cytokines: TNFalpha, IL-1ra, IL-6, IL-8, IL-10 as well as CRP were investigated in patients with colorectal cancer, prior treatment and 1, 10 and 42 days after surgery. There was an increase of the levels of CRP, IL-6 and IL-10 in most patients 24 hours after surgery. The levels of IL-1ra were elevated in patients in stage C and in several patients in stage B of the disease and there was a decrease of circulating TNFalpha in stage B patients. On day 10 and 42 after surgery, the levels of cytokines followed various patterns.

Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients

“…In the sera of the patients with CRC, a significant elevation was also noted in the levels of the pro-inflammatory cytokines TNF-α, IL-6, and IL-8, consistent with the results earlier presented by other authors (Belluco et al 2000;Kamiñska et al 2000). Moreover, the levels of the cytokines in the patients with CRC and those with CD showed no significant differences.…”

“…Already published data have presented contradictory results Table 1. Cytokine levels (TNF-α, IL-1β, IL-6, IL-8, IL-10) in sera of the healthy subjects and patients with UC, CD, or CRC related to preoperative serum IL-10 levels in CRC patients, pointing to a relationship between higher IL-10 levels and an inoperable tumor (Galizia et al 2002;Kamiñska et al 2000). On the other hand, our study was conducted in patients with operable CRC (Dukes' stage B), which may explain the contradictions.…”

Serum IL-6, TNFα and CRP levels in Greek colorectal cancer patients: Prognostic implications

“…On the other hand, high expression of this marker in Dukes' C CRC Japanese patients was a favorable indicator of prognosis [3] . Another study reported that, among other cytokines, TNF was significantly elevated in stage B patients prior to surgery [30] .…”

“…However, it has been postulated that proin fl amm ato ry cy to kin es st ron gl y i nf lu e nce t he immunological status of CRC [3] . Among them, IL-6 and TNF can initiate the innate immune response by inducing the acute phase of inflammation [4,5] .…”

THE INFLUENCE OF HUMAN LEUKEMIA DIFFERENTIATION FACTOR ON ABILITY OF BLOOD CELLS TO PRODUCE IL-1β, IL-1ra AND IL-8 IN CHRONIC ATROPHIC GASTRITIS, ADENOMAS AND ADENOCARCINOMAS OF THE STOMACH

“…В частности, IL-1β активирует продукцию IL-8, стимулирующего пролиферацию опухолевых клеток и участвующего в ангиогенезе, который, в конечном счете, обеспечивает инвазию опухоли и метастазирование [9]. IL-1ra, являющийся ре-цепторным антагонистом IL-1 и образующийся в ответ на повышенные уровни последнего, с од-ной стороны, может ограничивать его пролифе-ративные и ангиогенные эффекты, а с другой -может поддерживать воспаление на таком уровне, когда не происходит элиминации возникающих атипических клеток и создаются все предпосыл-ки для возникновения опухоли и ее дальнейшего прогрессирования [4,6].…”