CRT-102 Discordance Between Coronary Artery Calcium Score and Framingham Risk Score in a Saudi and Veteran American Population

Alasnag, Mirvat; Umakanthan, Branavan; Awar, Ashraf; Alnasser, Ibrahim M; Foster, Gary P.

doi:10.1016/j.jcin.2013.01.011

Cited by 1 publication

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“…They recommended further large regional prospective studies to better understand the baseline characteristics of CAD risk factors in middle eastern populations. 28 An earlier study in the Middle East by Dakik et al on the prevalence of CAC in 1154 asymptomatic men and women in Lebanon found that the mean CAC score as well as the percentiles increased consistently with age, except for those more than 74 years old. The CAC scores were higher in men than women in each age group, findings that suggest that the CAC score distribution in the Middle East is similar to published international data.…”

Section: Discussionmentioning

confidence: 94%

High prevalence of coronary artery calcification in Saudi patients with normal myocardial perfusion

Fathala

Bukhari

Shoukri

et al. 2017

Annals of Saudi Medicine

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BACKGROUNDNormal single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) has a high negative predictive value for ischemic heart disease. Thus, the presence of subclinical coronary atherosclerosis detected by coronary artery calcification (CAC) score in patients who have undergone SPECT MPI is unknown.OBJECTIVESDetermine the prevalence of coronary artery calcification (CAC) in patients with normal SPECT MPI and examine the association of CAC with conventional coronary artery disease (CAD) risk factors.DESIGNCross-sectional analytical study using medical records from February 2010 to April 2016.SETTINGSSingle tertiary-care center.PATIENTS AND METHODSWe studied patients referred from the outpatient clinical services for clinically indicated noninvasive CAD diagnosis with MPI SPECT. CAC scoring was subsequently performed within 3 months after a normal MPI. We excluded patients with chest pain or decompensated heart failure or patients with a history of CAD. The study population was divided into three groups: patients with a CAC score of 0, a CAC score from 1 to 300, and a CAC score more than 300. The groups were analyzed by age and other demographic and clinical characteristics.MAIN OUTCOME MEASURE(S)Prevalence of CAC in patients with normal MPI.RESULTSThe prevalence of CAC was 55% (n=114) in 207 patients with a mean (SD) age of 57.1 (10.4) years. Twelve percent had severe coronary atherosclerosis (CAC score >300). All patients had a normal MPI SPECT. CAC scores were 0 for 93 patients (45%), 1 to 300 for 89 (43%), and more than 300 for 24 (12%). There was a strong association between CAC score and age (P<.0001), male sex (P<.0001), and diabetes mellitus (P=.042), but no association between CAC score and hypertension (P=.153), family history of CAD (P=.23), obesity (P=.31), hypercholesterolemia (P=.071), or smoking (P=.308).CONCLUSIONSThe prevalence of CAC is high in this study population of patients with normal SPECT MPI. Age, male sex and diabetes were risk factors associated with CAC.LIMITATIONSSingle center and small study population.

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Section: Discussionmentioning

confidence: 94%